Results 101 to 110 of about 15,916,154 (299)

Managing diversity in practical ambient assisted living ecosystems [PDF]

, 2010
Poster presentation at the AALIANCE Conference, Malaga, Spain, March, 11-12 2010Though the motivation for developing ambient assisted living (AAL) systems is incontestable, significant challenges exist in realizing the ambience that is essential to the ...
O'Grady, Michael, Dragone, Mauro; id_orcid, O\u27Grady, Michael, O'Hare, G. M. P. (Greg M. P.), O\u27Grady, Michael J., O\u27Hare, Gregory M.P., O’Grady, Michael J., O'Hare, Gregory M.P., O'Hare, Gregory M. P., Gurrin, Cathal, O'Grady, Michael J., Tynan, Richard, Dragone, Mauro, Walsh, Michael, O\u27Hare, G. M. P. (Greg M. P.), O'Hare, Gregory M.P., O'Grady, Michael J.   +16 more
core   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

RPAS for documentation of Nazca aqueducts

European Journal of Remote Sensing, 2019
In Peru, there are not many aqueduct systems, only in Nasca region. They are popularly known as “puquíos”, hidden in the dry landscape. Most of them are around the city of Nasca known mainly for the nearby famous Nazca lines and geoglyphs.
Jaroslav Šedina, Martina Hůlková, Karel Pavelka, Karel Pavelka, jr   +3 more
doaj   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Multi-objective optimization of integrated water reuse systems at a cluster scale

, 2010
Population growth and higher standards of living have and will continue to drive an increasing demand for water supplies. Past practices have seen conventional water sources diminish which has lead to environmental degradation.
Brock, C., McGregor, C., Colsey, C., Russo, E., Maier, H., Dandy, S.   +5 more
core   +1 more source

Amoebae contribute to the diversity and fate of antibiotic resistance genes in drinking water system

Environment International
Free-living amoebae represent a significant eukaryotic group that thrives in drinking water systems, posing considerable risks to water quality due to their inherent pathogenicity and associations with various microorganisms.
Lu Ma, Fei Liu, Min Zhou, Mian Zhang, Jianyi Zheng, Zihe Wang, Zhili He, Qingyun Yan, Bo Wu, Cheng Wang, Longfei Shu   +10 more
doaj   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Improving Water Quality by Combined Sedimentation and Slow Sand Filtration: A Case Study in a Maasai Community, Tanzania

Applied Sciences
Some Maasai communities in northern Tanzania face severe water quality and scarcity issues, significantly impacting the health and living conditions of the local population.
Nadav Bachar, Noga Lindenstrauss, Saar David, Micha Mirkin, Noam Polani, Osher Gueta, Shaked Partush, Avner Ronen   +7 more
doaj   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

Molecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani, Dominic Guanzon, Andrew Lai, Katherin Scholz‐Romero, Sarah Reed, Edita Ritmejeryte, Rohan Lourie, Naven Chetty, Kaltin Ferguson, Carlos Salomon   +9 more
wiley   +1 more source