Results 101 to 110 of about 2,046,162 (340)

Power and Efficiency in Living Systems

Sci
Energy transformation powers change in the universe. In physical systems, maximal power (rate of energy input or output) may occur only at submaximal efficiency (output/input), or conversely, maximal efficiency may occur only at submaximal power.
Douglas S. Glazier
doaj   +1 more source

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

Molecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann, Eduardo García‐Galea, Alice O'Farrell, Zak Kinsella, Maxime Meylan, Florent Petitprez, Ingrid Arijs, Tom Venken, Hari Ps, Adrian Lärkeryd, Ian Miller, Janick Selves, Nadja Meindl‐Beinker, Fiorella Ruiz‐Pace, Elena Élez, Raquel Comas‐Navarro, Frank Lincoln, Dirk Fey, Gift Nyamundanda, Aoife Nolan, Joern Lewin, Raquel Perez‐Lopez, Jonathan Briody, Kathleen Bennett, Walter Kolch, David Matallanas, Alexander Kel, Enrique Arenas, Joaquín Arribas, Bart Ghesquière, Josep Tabernero, Julie Meilleroux, Deborah McNamara, Ray McDermott, Marvin Lim, Mary O'Reilly, Brian Bird, Lisa Stack, Lucia Moloney, Patrick Morris, Keith Egan, Maciej Milewski, Lars Scheuer, Joachim Behringer, Georg Bolz, Ramon Salazar, Cristina Santos, Andrea Ruiz, Orla Casey, Verena Murphy, Matthias Ebert, Livio Trusolino, Diether Lambrechts, Anguraj Sadanandam, Catherine Sautès‐Fridman, Jochen Prehn, Paolo Nuciforo, Jacques Fieschi, Florence Monville, Darran O'Connor, Wolf Fridman, Annette Byrne   +61 more
wiley   +1 more source

The Study of Biological Soil Crusts: Hotspots and Prospects

, 2013
Biological soil crusts (BSCs), which cover 35% of the continents and exceed 70% of the living cover in parts of region, play important ecological roles in the evolution of soil-water-plant systems in arid and semiarid areas.
Xie, Yongsheng, Zhang, Xingchang, Bu, CF (reprint author), Northwest A&F Univ, Inst Soil & Water Conservat, Yangling 712100, Shaanxi, Peoples R China., Bu, Chongfeng, Wu, Shufang   +4 more
core   +1 more source

Chromosome-level genome assembly of Chinese water scorpion Ranatra chinensis (Heteroptera: Nepidae)

Scientific Data
Heteroptera (the true bugs), one of the most diverse lineages of insects, diversified in feeding strategies and living habitats, and thus become an ideal lineage for studies on adaptive evolution.
Xinzhi Liu, Ling Ma, Li Tian, Fan Song, Tongyin Xie, Yunfei Wu, Hu Li, Wanzhi Cai, Yuange Duan   +8 more
doaj   +1 more source

Learning from the Hydraulic Heritage of Figuig, Morocco

Blue Papers
In the face of water scarcity and climate change, the Figuig Oasis exemplifies resilience through the integration of culture, heritage and sustainable development.
Ouafa Messous
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Benchmarking the energy-health nexus for more efficient water recycling operations

, 2015
Data source: Supplementary data, https://researchdata.ands.org.au/water-recycling-energy-benchmarking-performance/495005This paper reports on the findings of a 12-month study, undertaken at SA Water and supported by the Australian Water Recycling Centre ...
Van Den Akker, B., Short, M.D., Regel, R.   +2 more
core  

Water Sensitive Urban Design: An Investigation of Current Systems, Implementation Drivers, Community Perceptions and Potential to Supplement Urban Water Services

, 2016
Large scale centralised water, wastewater and stormwater systems have been implemented for over 100 years. These systems have provided a safe drinking water supply, efficient collection and disposal of wastewater to protect human health, and the ...
Ashok K. Sharma, D. Pezzaniti, B. Myers, S. Cook, G. Tjandraatmadja, P. Chacko, S. Chavoshi, D. Kemp, R. Leonard, B. Koth, A. Walton   +10 more
semanticscholar   +1 more source

Viability of karezes (ancient water supply systems in Afghanistan) in a changing world

Applied Water Science, 2017
The Afghanistan population living far from rivers relies upon groundwater delivered from karezes (sub-horizontal tunnels). Karezes exploit unconfined groundwater in alluvial fans recharged largely by snowmelt from the Hindu Kush, the central mountain ...
G. Macpherson, W. C. Johnson, Huan Liu
semanticscholar   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source