Results 81 to 90 of about 284,893 (258)

RPAS for documentation of Nazca aqueducts

European Journal of Remote Sensing, 2019
In Peru, there are not many aqueduct systems, only in Nasca region. They are popularly known as “puquíos”, hidden in the dry landscape. Most of them are around the city of Nasca known mainly for the nearby famous Nazca lines and geoglyphs.
Jaroslav Šedina, Martina Hůlková, Karel Pavelka, Karel Pavelka, jr   +3 more
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Amoebae contribute to the diversity and fate of antibiotic resistance genes in drinking water system

Environment International
Free-living amoebae represent a significant eukaryotic group that thrives in drinking water systems, posing considerable risks to water quality due to their inherent pathogenicity and associations with various microorganisms.
Lu Ma, Fei Liu, Min Zhou, Mian Zhang, Jianyi Zheng, Zihe Wang, Zhili He, Qingyun Yan, Bo Wu, Cheng Wang, Longfei Shu   +10 more
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Improving Water Quality by Combined Sedimentation and Slow Sand Filtration: A Case Study in a Maasai Community, Tanzania

Applied Sciences
Some Maasai communities in northern Tanzania face severe water quality and scarcity issues, significantly impacting the health and living conditions of the local population.
Nadav Bachar, Noga Lindenstrauss, Saar David, Micha Mirkin, Noam Polani, Osher Gueta, Shaked Partush, Avner Ronen   +7 more
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Deep into the Water: Exploring the Hydro-Electromagnetic and Quantum-Electrodynamic Properties of Interfacial Water in Living Systems

OALib, 2019
Normal water structures are maintained largely by interactions with bi-omacromolecular surfaces and weak electromagnetic fields, which enable extended networks for electron and proton conductivity. All standard chemistry is totally reliant on electrostatics and avoids all mention of elec-trodynamics and the consequent radiation field, which is ...
openaire   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Biological testing of ships’ ballast water indicates challenges for the implementation of the Ballast Water Management Convention

Frontiers in Marine Science
Ships’ ballast water and sediments are vectors that contribute to the unintentional spread of aquatic non-native species globally. Ballast water management, as well as commissioning testing of ballast water management systems and compliance monitoring ...
Okko Outinen, Sarah A. Bailey, Oscar Casas-Monroy, Stephanie Delacroix, Sonia Gorgula, Evelina Griniene, Jenni E. Kakkonen, Greta Srebaliene   +7 more
doaj   +1 more source