Results 101 to 110 of about 57,467,955 (246)

Skin electroporation of a plasmid encoding hCAP-18/LL-37 host defense peptide promotes wound healing. [PDF]

, 2014
Host defense peptides, in particular LL-37, are emerging as potential therapeutics for promoting wound healing and inhibiting bacterial growth. However, effective delivery of the LL-37 peptide remains limiting.
Becerikli, Mustafa, Vandermeulen, Gaëlle, Stricker, Ingo, Sonveaux, Pierre, Lehnhardt, Marcus, Préat, Véronique, Jacobsen, Frank, Hancock, Robert Ew, Porporato, Paolo, Porporato, Paolo E, Lam, Martin C, Steinstraesser, Lars, Chereddy, Kiran Kumar   +12 more
core   +1 more source

The Novel Viral Non‐Coding RNA LMP2A‐IT1 Promotes the Lytic Replication of EBV

Advanced Science, EarlyView.
Decades after its discovery, EBV's genome still harbours unannotated “dark matter”. LMP2A‐IT1, a novel EBV‐encoded transcript identified in this work, is strongly upregulated during lytic replication and promotes BZLF1 expression, likely through activation of inflammatory responses, thereby enhancing viral propagation in a self‐reinforcing positive ...
Zheng‐Zhou Lu, Jun‐Fei Wu, Nannan Zhu, Ming‐Hui Yang, Le‐Le Zhang, Yuan‐Tao Liu, Wei‐Jun Chen, Jin‐Kun Tang, Jia‐Wei Ge, Chao‐Bo Lei, Tao Zhang, Yu Wang, Chao‐Yun Huang, Qian Zhong, Mu‐Sheng Zeng, Yan Li   +15 more
wiley   +1 more source

CKMT1 Counteracts VDAC1 Oligomerization‐Induced Neuronal Pyroptosis Through Steric Hindrance in Ischemic Stroke

Advanced Science, EarlyView.
CKMT1 inhibits VDAC1 oligomerization via a dual‐region mechanism: its NTD interacts with the VDAC1 C‐terminal domain, while residues 1–39 sterically hinder dimerization, thereby reducing mtDNA leakage and AIM2 inflammasome activation, suppressing neuronal pyroptosis and protecting against cerebral ischemic injury. ABSTRACT Ischemic stroke is one of the
Xiaoyu Wang, Sai Shi, Jianghui Wu, Jingge Zhang, Shuqin Li, Yuyan Hu, Haifeng Yin, Chenguang Zhao, Dong Ma, Xiaohui Xian, Lizhe Liu, Ling Zhao, Xiyun Liu, Zhikai Yu, Lihua Dong, Wenbin Li, Lingyan Zhang, Min Zhang   +17 more
wiley   +1 more source

Emerging roles of the host defense peptide LL-37 in human cancer and its potential therapeutic applications

, 2010
Human cathelicidin LL-37, a host defense peptide derived from leukocytes and epithelial cells, plays a crucial role in innate and adaptive immunity.
Betancourt, Aline M., Fan, Daiming, Lee, Chung W., Sung, Joseph J.Y., Coffelt, Seth B., Cho, Chi H., Wang, Guangshun, Wu, William K.K., Wu, Kaichun, Yu, Jun   +9 more
core   +1 more source

ARGININE-LYSINE SWAPS SELECTIVELY ENHANCE ANTIMICROBIAL ACTIVITY OVER CYTOTOXIC ACTIVITY OF LL-37 [PDF]

, 2018
LL-37 is the only cationic peptide belonging to the cathelicidin family expressed in humans. LL-37 has bactericidal activity and exerts immunomodulatory functions forming, together with other peptides, the first line of defense against infections.
Enrico Balducci, Alessio Bonucci, Rebecca Pogni   +2 more
core   +1 more source

Cloning, Expression, and Purification of Antimicrobial Peptide LL-37 and Assessment of its Antimicrobial Effectiveness on Multiple-Drug-Resistant Acinetobacter Baumannii

مجله دانشکده پزشکی اصفهان, 2017
Background: Now a day, antibiotic resistance is a global problem. A way to solve this problem is production of alternative drugs. In this regard, today so many researches on antimicrobial peptides against pathogens are being done. LL-37 peptide is one of
Ehsan Zarei-Mehrvarz, Ehsanollah Ghaznavi-Rad, Shohreh Fahimi-Rad, Hamid Abtahi   +3 more
doaj  

Cubosomes for topical delivery of the antimicrobial peptide LL-37

, 2019
In this study, the use of cubosomes for topical delivery of the antimicrobial peptide (AMP) LL-37 was investigated. Topical delivery of AMPs is of great interest for treatment of skin infections caused by bacteria, such as Staphylococcus aureus.
Davoudi, Mina, Larsson, P. T., Håkansson, J., Boge, Lukas,, Mahlapuu, Margit, Ringstad, L., Johansson, J., H\ue5kansson, Joakim, Ringstad, Lovisa,, Johansson, Jenny,, Andersson, Therese,, Hallstensson, Karin, Ringstad, Lovisa, Hallstensson, Karin,, Mahlapuu, Margit,, Davoudi, Mina,, Andersson, Martin,, Andersson, M., Andersson, Martin, Johansson, Jenny, Håkansson, Joakim, Davoudi, M., Håkansson, Joakim,, Hallstensson, K., Boge, L., Larsson, Per Tomas,, Larsson, Per Tomas, Andersson, T., Boge, Lukas, Andersson, Therese, Lund University.   +30 more
core   +1 more source

The Role of Bacterial Filamentation in Response to the Antimicrobial Peptide LL-37

Urinary tract infections (UTIs) are one of the most common bacterial infections in humans. Uropathogenic E. coli (UPEC) are the primary cause of UTIs. During a UTI, UPEC invades bladder epithelial cells forming intracellular biofilm-like structures with ...
Madison Tomlinson (18162091)
core   +1 more source

Engineering a multifunctional LL37-TP5 hybrid peptide with potent antimicrobial endotoxin-neutralizing and anti-inflammatory properties

Frontiers in Pharmacology
The increasing prevalence of antimicrobial resistance and endotoxin-mediated inflammation highlights the need for alternative therapeutic strategies that combine antibacterial and immunomodulatory functions.
Baseer Ahmad, Baseer Ahmad, Kiran Khurshid, Wei Xubiao, Kashif Hussain, Muhammad Asif Raza, Haizhou Gong, Christina Hölzel, Si Dayong   +8 more
doaj   +1 more source

Identification of bacterial biofilm and the Staphylococcus aureus derived protease, staphopain, on the skin surface of patients with atopic dermatitis

Scientific Reports, 2017
Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by an impaired epidermal barrier, dysregulation of innate and adaptive immunity, and a high susceptibility to bacterial colonization and infection.
Andreas Sonesson, Kornelia Przybyszewska, Sigrid Eriksson, Matthias Mörgelin, Sven Kjellström, Julia Davies, Jan Potempa, Artur Schmidtchen   +7 more
doaj   +1 more source