Results 81 to 90 of about 278 (116)
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Multi-Epitope Microsphere Vaccine Modified Immunological Efficacy Against LMBV in Largemouth Bass (Micropterus salmoides)

Virology
The largemouth bass iridovirus disease, caused by the largemouth bass virus (LMBV), has a mortality rate of up to 60 %, and no commercial vaccine is available. This study focused on developing a vaccine against LMBV by engineering Escherichia coli to express highly immunogenic antigen epitopes (S11, S12, S3) from preliminary research.
Fu-Yi Jiang
exaly   +3 more sources

The role of largemouth bass NF-κB/p65: Inhibition of LMBV and activator of IL-18 promoter

Fish & Shellfish Immunology
Nuclear factor-κB (NF-κB)/p65, a vital signaling molecule in the NF-κB pathway, participates in diverse physiological functions and host-virus interactions. However, the involvement of NF-κB/p65 in fish virus infection remains poorly understood. In this study, we explored the role of the p65 in virus infection and its impact on IL-18 regulation in ...
Liqun, Wang   +6 more
openaire   +2 more sources

Tissue Tropism and Pathogenesis of LMBV in Largemouth Bass: A Comparative Study of Injection and Immersion Infection Models

Journal of Fish Diseases
ABSTRACT Largemouth bass ranavirus (LMBV) poses a significant threat to the aquaculture industry by causing severe systemic disease and substantial economic losses. This study investigates the tissue distribution, pathological damage, and host response following LMBV‐GD1909 infection using two infection models: experimental injection ...
Tianmei, Hu   +12 more
openaire   +2 more sources

Comparison of Lethal and Nonlethal Sampling Methods for the Detection of Largemouth Bass Virus (LMBV) from Largemouth Bass in the Upper Mississippi River

Journal of Aquatic Animal Health, 2018
Abstract Traditional methodologies to identify fish pathogens require euthanasia before the collection of tissue samples. While these methods are standardized and proven, there are instances where nonlethal alternatives would be preferred.
Eric, Leis   +6 more
openaire   +2 more sources

Surface-displayed MCP-3 vaccine in Bacillus subtilis elicits protective immune responses against LMBV infection in largemouth bass

Fish & Shellfish Immunology
Largemouth bass virus (LMBV) is a major pathogen threatening the aquaculture of largemouth bass, causing significant economic losses. Oral vaccination offers a practical and efficient strategy for disease prevention in farmed fish. In this study, a fusion CotC-MCP-3 gene was introduced into Bacillus subtilis 168 (Bs168) to enable surface display of the
Ruiqi, Lin   +8 more
openaire   +2 more sources

Oral administration of IFN-γrel elicits antiviral immunity and enhances protective efficacy against LMBV in largemouth bass (Micropterus salmoides)

Fish & Shellfish Immunology
Largemouth bass virus (LMBV) poses a severe threat to global aquaculture, yet effective antiviral strategies remain limited. This study characterized the antiviral properties of type II interferon IFN-γrel in largemouth bass and evaluated its prophylactic and therapeutic efficacy via oral delivery.
Zemiao, Zhang   +8 more
openaire   +2 more sources

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