Results 1 to 10 of about 53,726 (303)
Aptamer-iRNAs as Therapeutics for Cancer Treatment
Pharmaceuticals, 2018 Aptamers are single-stranded oligonucleotides (ssDNA or ssRNA) that bind and recognize their targets with high affinity and specificity due to their complex tertiary structure.
Mario M. Soldevilla +3 more
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Translational opportunities in aptamer and nanobody lateral flow assays within the WHO REASSURED framework [PDF]
Sensors & DiagnosticsThe World Health Organization's REASSURED framework underscores the role of lateral flow assays (LFAs) in addressing diagnostic access gaps in low-resource regions affected by emerging and re-emerging pathogens, neglected tropical diseases, and diseases ...
Evan T. Monk +3 more
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Materials Today Bio, 2023 Given the dynamic nature of engineered vascular networks within biofabricated tissue analogues, it is instrumental to have control over the constantly evolving biochemical cues within synthetic matrices throughout tissue remodeling.
Deepti Rana +6 more
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A Novel PD-L1-targeting Antagonistic DNA Aptamer With Antitumor Effects
Molecular Therapy: Nucleic Acids, 2016 The PD-1/PD-L1 axis is a major pathway involved in tumor immune evasion. Here, we report the novel PD-L1 antagonizing DNA aptamer (aptPD-L1) and demonstrate an integrated pipeline that expedites therapeutic aptamer development. Aptamer can exert antibody-
Wei-Yun Lai +4 more
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Evaluation of the anti-Salmonella Aptamer using Bioinformatic Tools and ELAA Method [PDF]
Research in Molecular Medicine, 2022 Background: Identifying and measuring food pathogens and environmental samples require accurate and high-sensitivity and specific methods. In addition, Salmonella is a zoonotic bacteria that can directly cause human disease.
Fatemeh Bozorgmehr +2 more
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Biosensors, 2022 Nucleic acid aptamer-based research has focused on achieving the highest performance for bioassays. However, there are limitations in evaluating the affinity for the target analytes in these nucleic acid aptamer-based bioassays.
Yejin Park +4 more
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Molecular Docking Insight into the Label-Free Fluorescence Aptasensor for Ochratoxin A Detection
Molecules, 2023 Ochratoxin A (OTA) is the most common mycotoxin and can be found in wheat, corn and other grain products. As OTA pollution in these grain products is gaining prominence as a global issue, the demand to develop OTA detection technology has attracted ...
Hua Ye +7 more
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Enzyme-mimic activity study of superstable and ultrasmall graphene encapsuled CoRu nanocrystal
APL Materials, 2021 Nanozymes hold huge potential in various fields, but their much lower catalytic activities than natural enzymes greatly limit their extensive applications. Recent studies indicated that an enhanced enzyme-like activity could be obtained by decreasing the
Phouphien Keoingthong +7 more
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PharmaceuticsBackground: CD25, the α-chain of the interleukin-2 (IL-2) receptor, is highly expressed on malignant cells and tumor-infiltrating regulatory T-cells (Tregs) in hematologic malignancies, making it an attractive therapeutic target for tumor elimination and
Sanghyeok Woo +6 more
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Aptamer-Modified Semiconductor Quantum Dots for Biosensing Applications
Sensors, 2017 Semiconductor quantum dots have attracted extensive interest in the biosensing area because of their properties, such as narrow and symmetric emission with tunable colors, high quantum yield, high stability and controllable morphology.
Lin Wen +4 more
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