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Improvement of Aptamer Affinity by Dimerization
Sensors, 2008 To increase the affinities of aptamers for their targets, we designed an aptamerdimer for thrombin and VEGF. This design is based on the avidity of the antibody, whichenables the aptamer to connect easily since it is a single-strand nucleic acid. In this
Koji Sode +2 more
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An Aptamer against MNK1 for Non-Small Cell Lung Cancer Treatment
Pharmaceutics, 2023 Lung cancer is the leading cause of cancer-related death worldwide. Its late diagnosis and consequently poor survival make necessary the search for new therapeutic targets.
Rebeca Carrión-Marchante +11 more
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Aptamer Applications in Neuroscience [PDF]
Pharmaceuticals, 2021 Being the predominant cause of disability, neurological diseases have received much attention from the global health community. Over a billion people suffer from one of the following neurological disorders: dementia, epilepsy, stroke, migraine, meningitis, Alzheimer’s disease, Parkinson’s disease, multiple sclerosis, amyotrophic lateral sclerosis ...
Meric Ozturk +2 more
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Aptamers and aptamer targeted delivery [PDF]
RNA Biology, 2009 When aptamers first emerged almost two decades ago, most were RNA species that bound and tagged or inhibited simple target ligands. Very soon after, the 'selectionologists' developing aptamer technology quickly realized more potential for the aptamer.
Amy C, Yan, Matthew, Levy
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Method to Determine the Optimal Aptamer-to-Bead Ratio by Using Flow Cytometry
Scientifica, 2023 Research on the effective attachment of aptamers to beads, which is essential for using aptamers, has made relatively little progress. Here, we demonstrate a new method based on flow cytometry to determine the optimal aptamer-to-bead ratio for aptamer ...
Sun Young Lee +5 more
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Nucleic Acids Research, 2004 The aptamer database is designed to contain comprehensive sequence information on aptamers and unnatural ribozymes that have been generated by in vitro selection methods. Such data are not normally collected in 'natural' sequence databases, such as GenBank.
Jennifer F. Lee +3 more
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Global Challenges, 2023 Virus recognition has been driven to the forefront of molecular recognition research due to the COVID‐19 pandemic. Development of highly sensitive recognition elements, both natural and synthetic is critical to facing such a global issue.
Mark V. Sullivan +13 more
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Molecularly Imprinting–Aptamer Techniques and Their Applications in Molecular Recognition
Biosensors, 2022 Molecular imprinting–aptamer techniques exhibit the advantages of molecular imprinting and aptamer technology. Hybrids of molecularly imprinted polymer–aptamer (MIP–aptamer) prepared by this technique have higher stability, binding affinity and superior ...
Qingqing Zhou, Zhigang Xu, Zhimin Liu
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Aptamer and aptamer pharmaceuticals [PDF]
SCIENTIA SINICA Chimica, 2018 Recently, molecule-based targeted therapy has achieved remarkable success in clinical, and opened up a new era particulraly in the field of cancer therapy. Monoclonal antibodies and small molecule inhibitors are two pillars of this field. Additionally, a single-strand nucleic acid molecule called “chemical antibody” has also attracted increasing ...
Ting Zheng, Ziyue Ma, Quan Du
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Aptamers in Immunotherapy [PDF]
Human Gene Therapy, 2008 Numerous nucleic acid ligands, also termed decoys or aptamer, have been developed during the past 20 years that can bind to and inhibit the activity of many proteins. The concept that nucleic acid ligands could modulate the activity of proteins emerged from basic science studies of viruses and early work in the field of gene therapy.
Claudia M, Dollins +2 more
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