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CD25-Targeted Aptamer–Drug Conjugate for the Treatment of CD25-Expressing Hematological Malignancies [PDF]
PharmaceuticsBackground: CD25, the α-chain of the interleukin-2 (IL-2) receptor, is highly expressed on malignant cells and tumor-infiltrating regulatory T-cells (Tregs) in hematologic malignancies, making it an attractive therapeutic target for tumor elimination and
Sanghyeok Woo +6 more
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An Aptamer against MNK1 for Non-Small Cell Lung Cancer Treatment
Pharmaceutics, 2023 Lung cancer is the leading cause of cancer-related death worldwide. Its late diagnosis and consequently poor survival make necessary the search for new therapeutic targets.
Rebeca Carrión-Marchante +11 more
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Method to Determine the Optimal Aptamer-to-Bead Ratio by Using Flow Cytometry
Scientifica, 2023 Research on the effective attachment of aptamers to beads, which is essential for using aptamers, has made relatively little progress. Here, we demonstrate a new method based on flow cytometry to determine the optimal aptamer-to-bead ratio for aptamer ...
Sun Young Lee +5 more
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Global Challenges, 2023 Virus recognition has been driven to the forefront of molecular recognition research due to the COVID‐19 pandemic. Development of highly sensitive recognition elements, both natural and synthetic is critical to facing such a global issue.
Mark V. Sullivan +13 more
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Molecularly Imprinting–Aptamer Techniques and Their Applications in Molecular Recognition
Biosensors, 2022 Molecular imprinting–aptamer techniques exhibit the advantages of molecular imprinting and aptamer technology. Hybrids of molecularly imprinted polymer–aptamer (MIP–aptamer) prepared by this technique have higher stability, binding affinity and superior ...
Qingqing Zhou, Zhigang Xu, Zhimin Liu
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DNA-Based Molecular Engineering of the Cell Membrane
Membranes, 2022 The cell membrane serves as a barrier and gatekeeper to regulate the cellular transportation of substances and information. It plays a significant role in protecting the cell from the extracellular environment, maintaining intracellular homeostasis, and ...
Xiaodong Li +5 more
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Computational design of single-stranded DNA hairpin aptamers immobilized on a biosensor substrate
Scientific Reports, 2021 Aptamer interactions with a surface of attachment are central to the design and performance of aptamer-based biosensors. We have developed a computational modeling approach to study different system designs—including different aptamer-attachment ends ...
Iman Jeddi, Leonor Saiz
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Frontiers in Bioengineering and Biotechnology, 2022 Various biosensors based on aptamers are currently the most popular rapid detection approaches, but the performance of these sensors is closely related to the affinity of aptamers.
Yadi Qin +5 more
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Pharmaceuticals, 2021 Extracellular vesicles (EVs) have emerged into a novel vaccine platform, a biomarker and a nano-carrier for approved drugs. Their accurate detection and visualization are central to their utility in varied biomedical fields.
Soonjyoti Das +9 more
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Enhancement of in vivo targeting properties of ErbB2 aptamer by chemical modification.
PLoS ONE, 2023 Aptamers have great potential for diagnostics and therapeutics due to high specificity to target molecules. However, studies have shown that aptamers are rapidly distributed and excreted from blood circulation due to nuclease degradation.
Jun Young Park +4 more
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