Results 1 to 10 of about 19,390 (205)

Advantages, applications, and future directions of in vivo aptamer SELEX: A review

Molecular Therapy - Nucleic Acids
In vivo systematic evolution of ligands by exponential enrichment (SELEX) emerged as a transformative technique for directly identifying aptamers within living organisms.
Yuanyuan Yu
exaly   +4 more sources

Advancements in SELEX Technology for Aptamers and Emerging Applications in Therapeutics and Drug Delivery

Biomolecules
Nucleic acid aptamers, selected through the Systematic Evolution of Ligands by Exponential Enrichment (SELEX), are short nucleic acid sequences that exhibit high affinity and specificity towards diverse targets.
Fengchao Wang, Yunxia Luan
exaly   +4 more sources

Inside the Black Box: What Makes SELEX Better?

Molecules, 2019
Aptamers are small oligonucleotides that are capable of binding specifically to a target, with impressive potential for analysis, diagnostics, and therapeutics applications.
Alexander Kuznetsov, Natalia Komarova
exaly   +4 more sources

Advances in Aptamer Drug Delivery Systems for Treatment of Glioblastoma. [PDF]

Adv Sci (Weinh)
Aptamers have remarkable recognition capacity which is suitable for assisting drug delivery for GB. This review demonstrates that aptamers have great potential as targeted therapeutic carriers, conjugated to various therapeutic carriers, using a range of conjugation strategies and chemistries.
Paul AR, Mitchell AM, O'Neil D, Luo Y, Al-Jamal KT.   +4 more
europepmc   +2 more sources

Decoding sequence recognition code of nucleic acid-binding proteins of human-infecting DNA viruses. [PDF]

Imeta
Human‐infecting DNA viruses remain major health threats, yet the DNA‐recognition mechanisms of their nucleic acid‐binding proteins (NBPs) are poorly understood. Here, we systematically profiled 103 viral NBPs from human‐infecting DNA viruses, with three NBPs from non‐human‐infecting DNA viruses as controls, using high‐throughput screening.
Tang M, Yang S, Ma H, Guo R, Chen J, Zhang H, Zhang J, Sun W, Wei Y, Fan L, Yan J.   +10 more
europepmc   +2 more sources

SELEX-Based Aptamer Technologies for Toxin Analysis: Screening, Optimization, and Computational Assisted Design [PDF]

Toxins
The accurate and sensitive detection of toxin contamination remains a pressing challenge for food safety, environmental integrity, and public health, because conventional analytical methods suffer from high costs, poor field stability, and inadequate ...
Xinrui Shang, Chengming Yang, Huiyun Deng, Lianghua Wang, Mingjuan Sun   +4 more
doaj   +2 more sources

Comparison of Whole-Cell SELEX Methods for the Identification of Staphylococcus Aureus-Specific DNA Aptamers

Sensors, 2015
Whole-cell Systemic Evolution of Ligands by Exponential enrichment (SELEX) is the process by which aptamers specific to target cells are developed. Aptamers selected by whole-cell SELEX have high affinity and specificity for bacterial surface molecules ...
Jongguk Lim, Giyoung Kim
exaly   +3 more sources

The Potential Use of Aptamers in The Process of Drug Development [PDF]

Pharmaceutical Sciences, 2021
Single-stranded nucleic acids can fold and create unique 3-dimensional structures when interacting with other molecules. The unique structure can achieve high specificity and affinity for the particular target.
Tooba Gholikhani, Balam Jimenez Brito, Frey Livingston, Shalen Kumar   +3 more
doaj   +1 more source

Engineering Novel Aptameric Fluorescent Biosensors for Analysis of the Neurotoxic Environmental Contaminant Insecticide Diazinon from Real Vegetable and Fruit Samples

Frontiers in Bioscience-Landmark, 2022
Background: Diazinon is a widely used organophosphorus neurotoxic insecticide. It is a common environmental contaminant and a hazardous agri-waste. Its detection is critical to control entry into food systems and protect the environment. Methods: In this
Mai-Huong Thi Can, Ulhas Sopanrao Kadam, Kien Hong Trinh, Yuhan Cho, Hyebi Lee, Yujeong Kim, Sundong Kim, Chang Ho Kang, Sang Hee Kim, Woo Sik Chung, Sang Yeol Lee, Jong Chan Hong   +11 more
doaj   +1 more source

Surveillance Unattended Foliage Penetrating Radar for Border Control and Homeland Protection [PDF]

TransNav, 2013
The increasing request for safety, security and environment protection at local and national level reveal the deficiency of the traditional surveillance and control centers to satisfy the needs and requirements of modern border control systems for ...
Felicia Amato, Alfonso Farina, Michele Fiorini, Sergio Gallone   +3 more
doaj   +1 more source