Results 31 to 40 of about 12,731 (219)
BioResearch Open Access, 2012 Aptamers are molecules identified from large combinatorial nucleic acid libraries by their high affinity to target molecules. Due to a variety of desired properties, aptamers are attractive alternatives to antibodies in molecular biology and medical applications.
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RNA Capture-SELEX on Streptavidin Magnetic Beads
, 2023 SELEX has enabled the selection of aptamers, nucleic acids that can bind a defined ligand, in some cases with exceptionally high affinity and specificity. The SELEX protocol has been adapted many times to fit a variety of needs.
Kraus, Leon, Suess, Beatrix
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Principle of Emulsion PCR and Its Applications in Biotechnology
Journal of Animal Reproduction and Biotechnology, 2019 Emulsion polymerase chain reaction (PCR) is performed on compartmentalized DNA, allowing a large number of PCR reactions to be carried out in parallel. Emulsion PCR has unique advantages in DNA amplification.
Changhoon Chai
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Angewandte Chemie, EarlyView.This work presents the first enzymatic polymerization of defined metal‐chelator‐modified nucleotides that leverage polymerase fidelity for uniform (radio)metal loading with successful incorporation of five different metals: Ga, In, Tb, Lu, and Y.
Antonio A. W. L. Wong +2 more
wiley +2 more sources
Ka Band Phase Locked Loop Oscillator Dielectric Resonator Oscillator for Satellite EHF Band Receiver
Active and Passive Electronic Components, 2008 This paper describes the design and fabrication of a Ka Band PLL DRO having a fundamental oscillation frequency of 19.250 GHz, used as local oscillator in the low-noise block of a down converter (LNB) for an EHF band receiver.
S. Coco +3 more
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AND‐Logic‐Gated Aptamer Switch for Precise Targeting and Regulation of RNA G‐Quadruplexes
Angewandte Chemie, EarlyView.An AND‐logic‐gated aptamer switch enables tumor‐selective activation of RNA G‐quadruplex (rG4)‐targeting function. By combining cell‐surface recognition and intracellular redox sensing, the system achieves precise regulation of disease‐relevant RNA structures exclusively in tumor cells, with minimal off‐target effects in normal cells, offering a ...
Dan Wang, Ying Feng, Chun Kit Kwok
wiley +2 more sources
SELEX against whole-cell bacteria resulted in lipopolysaccharide binding aptamers
, 2022 Nucleic acid aptamers are target-specific oligonucleotides selected from combinatorial libraries through an iterative in vitro screening process known as Systemic Evolution of Ligands by Exponential Enrichment (SELEX).
Kurt, Hasan +4 more
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Angewandte Chemie, EarlyView.A simple, rapid, and portable gold‐coated filter tip‐based assay (GFTA) is developed for bacterial detection. The GFTA leverages cleavable functional nucleic acid probes as molecular recognition elements to target RNase H2, a highly conserved bacterial endoribonuclease, enabling sensitive and specific colorimetric detection of bacterial pathogens ...
Jiuxing Li +4 more
wiley +2 more sources
FSBC: fast string-based clustering for HT-SELEX data
BMC Bioinformatics, 2020 Background The combination of systematic evolution of ligands by exponential enrichment (SELEX) and deep sequencing is termed high-throughput (HT)-SELEX, which enables searching aptamer candidates from a massive amount of oligonucleotide sequences.
Shintaro Kato +7 more
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Lentokoneen matkustamohenkilökunnan työstä johtuvat psyykkiset ja sosiaaliset kuormitustekijät [PDF]
, 2020 Opinnäytetyön tavoitteena oli selvittää lentokoneen matkustamohenkilökunnan työtehtävät, jotka liittyvät turvallisuuteen ja tulkita niistä työn psyykkiset ja sosiaaliset kuormitustekijät. Työn toimeksiantaja oli Selex Oy.
Leskinen, Verna
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