Results 41 to 50 of about 19,390 (205)

FSBC: fast string-based clustering for HT-SELEX data

BMC Bioinformatics, 2020
Background The combination of systematic evolution of ligands by exponential enrichment (SELEX) and deep sequencing is termed high-throughput (HT)-SELEX, which enables searching aptamer candidates from a massive amount of oligonucleotide sequences.
Shintaro Kato, Takayoshi Ono, Hirotaka Minagawa, Katsunori Horii, Ikuo Shiratori, Iwao Waga, Koichi Ito, Takafumi Aoki   +7 more
doaj   +1 more source

Identification and Application of an Aptamer Targeting Papillary Thyroid Carcinoma Using Tissue-SELEX

, 2019
Aptamers, short DNA or RNA oligonucleotides, which evolved from systematic evolution of ligands by exponential enrichment (SELEX), can perform specific target recognition.
Ying Pu (161901), Jie Liao, Yuanyuan Deng, Yalan Hu, Huixia Liu, Ying Pu, Bo Yu (241082), Weihong Tan (9692), Jun Liu, Bo Liu, Yalan Hu (6824870), Jiani Zhang, Jiani Zhang (6824873), Yuanyuan Deng (5046299), Ke Chen (73307), Bo Liu (127343), Huixia Liu (161892), Jie Liao (41399), Bo Yu, Wen Zhong (425650), Jun Liu (42548), Ke Chen, Wen Zhong, Weihong Tan   +23 more
core   +1 more source

Lentokoneen matkustamohenkilökunnan työstä johtuvat psyykkiset ja sosiaaliset kuormitustekijät [PDF]

, 2020
Opinnäytetyön tavoitteena oli selvittää lentokoneen matkustamohenkilökunnan työtehtävät, jotka liittyvät turvallisuuteen ja tulkita niistä työn psyykkiset ja sosiaaliset kuormitustekijät. Työn toimeksiantaja oli Selex Oy.
Leskinen, Verna
core  

Evolution of Nucleic Acid Aptamers Capable of Specifically Targeting Glioma Stem Cells via Cell-SELEX

, 2019
Glioma stem cells (GSCs), a particular group of cells from gliomas, are capable of infinite proliferation and differentiation. Recent studies have shown that GSCs may be the root of tumor recurrence, metastasis, and resistance.
Dezhi Kang (131899), Zhi Zhu, Zhi Zhu (131920), Qiaoyi Wu (6860891), Qiaoyi Wu, Ningqin Lin, Liang Wu, Hongyao Wang, Tian Tian, Dengliang Wang, Chaoyong Yang, Chaoyong Yang (13531), Ningqin Lin (6860894), Dengliang Wang (2818270), Ruijun Tian (607368), Liang Wu (131111), Dezhi Kang, Hongyao Wang (2274496), Ruijun Tian, Tian Tian (170088)   +19 more
core   +1 more source

Iterative Selection of DNA Nanostructures for Cellular Uptake

Advanced Materials, EarlyView.
DNA nanostructures are promising cell targeting delivery vehicles for therapeutics, but the targeting behavior is not fully understood. In this study, libraries of DNA nanostructures that can be amplified and sequenced are combined with cellular uptake as a selection pressure to iteratively refine DNA structures taken up in cells to better understand ...
Anjali Rajwar, Lisa Eichhorn, Jakub Palacka, Sandra Ly, Erik Benson   +4 more
wiley   +1 more source

Improving Aptamer Affinity and Determining Sequence–Activity Relationships via Motif-SELEX

Journal of the American Chemical Society
The affinity of nucleic acid aptamers isolated in vitro via Systematic Evolution of Ligands by Exponential Enrichment (SELEX) is often limited because the entire potential sequence space cannot be screened.
Haixiang Yu, Juan Canoura, Caleb Byrd, Obtin Alkhamis, Adara Bacon, A. Yan, Bruce A. Sullenger, Yi Xiao   +7 more
semanticscholar   +1 more source

Aptamer-Conjugated Gold Nanoparticles Targeting Epidermal Growth Factor Receptor Variant III for the Treatment of Glioblastoma

International Journal of Nanomedicine, 2020
Li Peng,1,2,* Yanling Liang,1,* Xinxin Zhong,1 Zhiman Liang,1,2 Yinghong Tian,3 Shuji Li,1 Jingxue Liang,4 Ransheng Wang,4 Yuqi Zhong,4 Yusheng Shi,5 Xingmei Zhang1 1Key Laboratory of Mental Health of the Ministry of Education, Guangdong-Hong Kong-Macao ...
Peng L, Liang Y, Zhong X, Liang Z, Tian Y, Li S, Liang J, Wang R, Zhong Y, Shi Y, Zhang X   +10 more
doaj  

MetaboSense: An Integrated Quantum Dot‐Mediated Aptamer Assay and Modular Microfluidic Platform for Continuous In‐Line Monitoring of Lung Metabolism During Ex Vivo Perfusion

Advanced Science, EarlyView.
MetaboSense is a first‐of‐its‐kind microfluidic platform enabling continuous, in‐line monitoring of glucose and lactate during ex vivo lung perfusion. Combining a quantum dot–mediated aptamer assay with mixing, depletion, and optofluidic detection modules, it achieves 60–s temporal resolution and shows strong agreement with standard blood gas analyzers,
Sanjana Srikant, Pouyan Keshavarz Motamed, Thomas Borrillo, Lielle Ronen, Gabriel Siebiger, Guillermo Garza, Hesam Abouali, Md Fahim Al Fattah, Ines Jaber, Dayan Ban, Marcelo Cypel, Mingyao Liu, Shaf Keshavjee, Andrew T. Sage, Mahla Poudineh   +14 more
wiley   +1 more source

The SELEX and Neutral SELEX experiments.

, 2013
The normal SELEX experiment (shown with black arrows) begins with transcription of a DNA pool into RNA using T7 RNA polymerase. The RNAs then undergo counter selection against sequences binding non-specifically to the filter, followed by binding to the ...
Doris Chen (367236), Christina Lorenz (13577), Renée Schroeder (9110), Bob Zimmermann (367235), Tanja Gesell (51149)   +4 more
core   +1 more source

AI-assisted and structure-based small-molecule aptamer discovery: From SELEX to validation

Journal of Advanced Biotechnology and Experimental Therapeutics
Small-molecule aptamer discovery combines systematic evolution of ligands by exponential enrichment (SELEX), high-throughput-SELEX, artificial intelligence (AI)-assisted prioritization, structural modeling, experimental binding assays, and biosensor ...
Alexey S. Podshibiakin, Tatyana A. Grigoreva   +1 more
doaj   +1 more source