Results 41 to 50 of about 9,625 (180)
The FEBS Journal, EarlyView.DNA aptamers, Apt 60 and Apt 173, target the BamA protein to compromise outer membrane integrity in Pseudomonas aeruginosa, making it susceptible to Azithromycin, an antibiotic that is otherwise poorly effective due to the low‐permeability membrane.
Rupany Selvam +4 more
wiley +1 more source
Aptamer Cell-Based Selection: Overview and Advances
Biomedicines, 2017 Aptamers are high affinity single-stranded DNA/RNA molecules, produced by a combinatorial procedure named SELEX (Systematic Evolution of Ligands by Exponential enrichment), that are emerging as promising diagnostic and therapeutic tools.
Silvia Catuogno, Carla Lucia Esposito
doaj +1 more source
Plant Biotechnology Journal, EarlyView.ABSTRACT Drought stress severely restricts rice productivity, necessitating strategies to enhance stress resilience. Here, we identify translation termination as a tunable regulatory node for stress adaptation. Using 25 rounds of SELEX, we isolated RTAR, an RNA aptamer that binds the rice eukaryotic release factor 1 (OseRF1) with nanomolar affinity ...
Shuangfeng Dai +7 more
wiley +1 more source
Probing the molecular determinants of emission enhancement in RNA aptamer–metal complex systems
Photochemistry and Photobiology, EarlyView.Light up aptamer: fluorophore pairs are widely used in sensing and imaging, with coordination complex fluorophores providing specific benefits due to their long‐lived emission. Here, we examined key structural and electronic features of these metal complexes to identify the requirements for productive engagement with an RNA aptamer.
Sarah M. Kriger +3 more
wiley +1 more source
Analytical Science Advances, Volume 7, Issue 2, December 2026.We developed a novel aptasensor by integrating an anti‐lipopolysaccharide aptamer with a G‐quadruplex DNAzyme for the detection of Gram‐negative bacteria. This label‐free, spectroscopy‐based sensor detects E. coli with a limit of ∼2.7 × 105 cells/mL, providing a rapid, cost‐effective and specific method for identifying LPS‐containing bacteria ...
Hamidreza Majidifard +3 more
wiley +1 more source
The SELEX phototube RICH detector [PDF]
Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 1999 25 pages with 14 figures included.
Engelfried, J. +9 more
openaire +2 more sources
A novel artificial intelligence-based approach for identification of deoxynucleotide aptamers.
PLoS Computational Biology, 2021 The selection of a DNA aptamer through the Systematic Evolution of Ligands by EXponential enrichment (SELEX) method involves multiple binding steps, in which a target and a library of randomized DNA sequences are mixed for selection of a single ...
Frances L Heredia +2 more
doaj +1 more source
MANGO‐“Fruitcage”: A Conditional Photocage Utilizing a Fluorescence Light‐Up Aptamer
Advanced Optical Materials, Volume 14, Issue 29, 7 August 2026.Fruitcaging ‐ a proof of concept study of a conditional photocage (Thiazol‐Orange) activated upon binding to the fluorescence light up aptamer (Mango). The prolongation of the excited state lifetime explains the redirection of the reactive pathway toward photocleavage and provides a sensitive spectroscopic readout.
Konstantinos Stamatakis +6 more
wiley +1 more source
Cortisol Recognition by a Conformationally Responsive DNA Aptamer
Advanced Sensor Research, Volume 5, Issue 8, August 2026.The full‐length 85mer cortisol aptamer intrinsically populates two metastable conformational states in equilibrium. Cortisol binding redistributes the conformational ensemble by shifting the equilibrium between open and compact states while maintaining the underlying secondary structure. This ligand‐induced tertiary reorganization provides an atomistic
Lakshitha Jasin Arachchige +4 more
wiley +1 more source
Advanced Science, Volume 13, Issue 45, 13 August 2026.The aptamer WHY‐3E identifies PrPC as a CRC driver. Stabilized by USP18, endocytosed PrPC forms a LYN/STAT3 complex, upregulating MSN transcription to promote metastasis. Crucially, WHY‐3E sensitively detects PrPC‐positive circulating exosomes, establishing a robust theoretical foundation for non‐invasive clinical diagnostics.
Chunlin Wang +23 more
wiley +1 more source