Results 41 to 50 of about 12,731 (219)

Advances in BODIPY Derivatives for Antibacterial Phototherapy

Angewandte Chemie, EarlyView.
This review systematically summarizes the design strategies and structure‐activity relationships of BODIPY‐based antibacterial phototherapy, covering molecular engineering of small‐molecule photosensitizers and nanoplatforms, bacterial targeting and carrier design, and discussing the challenges and future perspectives associated with clinical ...
Li Lv, Heejeong Kim, Hongchen Zhai, Hanqi Ren, Silu Wang, Cong Sun, Yafu Wang, Hosoowi Lee, Juyoung Yoon, Hua Zhang   +9 more
wiley   +2 more sources

Advances in Aptamer-Based Biosensors and Cell-Internalizing SELEX Technology for Diagnostic and Therapeutic Application

Biosensors, 2022
Aptamers are a group of synthetic single-stranded nucleic acids. They are generated from a random library of single-stranded DNA or RNA by a technology named systematic evolution of ligands by exponential enrichment (SELEX). SELEX is a repetitive process
Zixuen Gan, Muhamad Aidilfitri Mohamad Roslan, Mohd Yunus Abd Shukor, Murni Halim, Nur Adeela Yasid, Jaafar Abdullah, Ina Salwany Md Yasin, Helmi Wasoh   +7 more
doaj   +1 more source

Identification and Application of an Aptamer Targeting Papillary Thyroid Carcinoma Using Tissue-SELEX

, 2019
Aptamers, short DNA or RNA oligonucleotides, which evolved from systematic evolution of ligands by exponential enrichment (SELEX), can perform specific target recognition.
Ying Pu (161901), Jie Liao, Yuanyuan Deng, Yalan Hu, Huixia Liu, Ying Pu, Bo Yu (241082), Weihong Tan (9692), Jun Liu, Bo Liu, Yalan Hu (6824870), Jiani Zhang, Jiani Zhang (6824873), Yuanyuan Deng (5046299), Ke Chen (73307), Bo Liu (127343), Huixia Liu (161892), Jie Liao (41399), Bo Yu, Wen Zhong (425650), Jun Liu (42548), Ke Chen, Wen Zhong, Weihong Tan   +23 more
core   +1 more source

Assembly of Protein‐DNA Framework Nanostructures: Structurally Defining Protein‐DNA Interfaces With Aptamer

Angewandte Chemie, EarlyView.
Rationally designed DNA multivalent aptamers direct specific protein binding to drive self‐assembly into protein‐DNA frameworks (PDFs). Structurally defined protein‐aptamer interfaces organize proteins into triangles, linear and ladderlike chains, and periodic two‐dimensional arrays, enabling precise control over orientation, connectivity, and overall ...
Zhe Zhang, Xuanyu Nan, Zhengyu Huang, Jin Jin, Cheng Tian, Lian Chen, Xiaoli Hu, Huawei He, Yuhe Renee Yang, Cheng Zhi Huang, Chengde Mao, Hua Zuo   +11 more
wiley   +2 more sources

Evolution of Nucleic Acid Aptamers Capable of Specifically Targeting Glioma Stem Cells via Cell-SELEX

, 2019
Glioma stem cells (GSCs), a particular group of cells from gliomas, are capable of infinite proliferation and differentiation. Recent studies have shown that GSCs may be the root of tumor recurrence, metastasis, and resistance.
Dezhi Kang (131899), Zhi Zhu, Zhi Zhu (131920), Qiaoyi Wu (6860891), Qiaoyi Wu, Ningqin Lin, Liang Wu, Hongyao Wang, Tian Tian, Dengliang Wang, Chaoyong Yang, Chaoyong Yang (13531), Ningqin Lin (6860894), Dengliang Wang (2818270), Ruijun Tian (607368), Liang Wu (131111), Dezhi Kang, Hongyao Wang (2274496), Ruijun Tian, Tian Tian (170088)   +19 more
core   +1 more source

Use of cell-SELEX to generate DNA aptamers as molecular probes of HPV-associated cervical cancer cells. [PDF]

PLoS ONE, 2012
Disease-specific biomarkers are an important tool for the timely and effective management of pathological conditions, including determination of susceptibility, diagnosis, and monitoring efficacy of preventive or therapeutic strategies.
Jessica C Graham, Helmut Zarbl
doaj   +1 more source

Enhancing Small Molecule Sensing With Aptameric Functionalized Nano Devices

Advanced Materials Technologies, EarlyView.
Unveiling an ultra‐sensitive, non‐invasive neurotransmitter sensor. For the first time, a nanoscale sensor for detecting an important neurotransmitter was demonstrated using micro‐electromechanical systems (MEMS) technology. Our approach utilized field‐effect transistor (FET)‐based readout to enable pico‐molar detection of biomarkers in sweat.
Thi Thanh Ha Nguyen, Cong Minh Nguyen, Quang Thang Trinh, Minh Anh Huynh, Khanh Vinh Ho, Dang Co Pham, Dzung Dao, Sven Ingebrandt, Sina Jamali, Xuan Thang Vu, Nam‐Trung Nguyen, Tuan‐Khoa Nguyen   +11 more
wiley   +1 more source

High-throughput sequencing SELEX for the determination of DNA-binding protein specificities in vitro

STAR Protocols, 2022
Summary: High-throughput sequencing SELEX (HT-SELEX) is a powerful technique for unbiased determination of preferred target motifs of DNA-binding proteins in vitro.
Raphaël Pantier, Kashyap Chhatbar, Grace Alston, Heng Yang Lee, Adrian Bird   +4 more
doaj   +1 more source

Hijacking the Host Clock: A Nematode Effector Antagonizes Soybean Circadian Defense and Translation Control

Advanced Science, EarlyView.
Soybean employs its circadian clock, governed by GmCCA1, to rhythmically defend against soybean cyst nematodes. The pathogen retaliates by secreting the effector Hg4E02, which hijacks the clock to suppress defense and co‐opt the host's translation machinery for nutrient acquisition.
Xingwei Wang, Yufeng Xu, Yanfei Hu, Lijun Cao, Ru Jiang, Changtian Chen, Rick Masonbrink, Thomas Maier, Yuchen Tu, Yabo Shi, Enhui Liu, Lingan Kong, Chan Guo, Wei Zhao, Peng Shi, Wenzhen Du, Andrew Severin, Thomas Baum, Deliang Peng, Huan Peng, Mian Zhou, Wei Wang   +21 more
wiley   +1 more source

Aptamer-Conjugated Gold Nanoparticles Targeting Epidermal Growth Factor Receptor Variant III for the Treatment of Glioblastoma

International Journal of Nanomedicine, 2020
Li Peng,1,2,* Yanling Liang,1,* Xinxin Zhong,1 Zhiman Liang,1,2 Yinghong Tian,3 Shuji Li,1 Jingxue Liang,4 Ransheng Wang,4 Yuqi Zhong,4 Yusheng Shi,5 Xingmei Zhang1 1Key Laboratory of Mental Health of the Ministry of Education, Guangdong-Hong Kong-Macao ...
Peng L, Liang Y, Zhong X, Liang Z, Tian Y, Li S, Liang J, Wang R, Zhong Y, Shi Y, Zhang X   +10 more
doaj