Results 61 to 70 of about 20,710 (205)
Performing SELEX experiments in silico
The Journal of Chemical Physics, 2017 Due to the sequence-dependent nature of the elasticity of DNA, many protein-DNA complexes and other systems in which DNA molecules must be deformed have preferences for the type of DNA sequence they interact with. SELEX (Systematic Evolution of Ligands by EXponential enrichment) experiments and similar sequence selection experiments have been used ...
Wondergem, A.J. +2 more
openaire +4 more sources
Chemistry – A European Journal, EarlyView.Using kanamycin A as a model target, we developed click‐capture SELEX to identify nucleobase‐modified aptamers capable of binding small molecules in solution. This approach enables flexible incorporation of nucleobase modifications via CuAAC, allowing the chemical properties of the aptamer to be tailored to the target molecule.
Philipp Menke +5 more
wiley +1 more source
Bio-SELEX: A Strategy for Biomarkers Isolation Directly from Biological Samples
Methods and Protocols, 2023 Bio-SELEX is a revolutionary method for the discovery of novel biomarkers within biological samples, offering profound insights into diagnosing both infectious and non-infectious diseases.
Juan David Ospina-Villa +2 more
doaj +1 more source
A DNA aptamer for binding and inhibition of DNA methyltransferase 1. [PDF]
, 2019 DNA methyltransferases (DNMTs) are enzymes responsible for establishing and maintaining DNA methylation in cells. DNMT inhibition is actively pursued in cancer treatment, dominantly through the formation of irreversible covalent complexes between small ...
Adkins, Gary Brent +12 more
core
Implantable electrochemical sensors for continuous blood monitoring
FlexMat, EarlyView.Implantable electrochemical sensors enable direct, in situ, and continuous blood monitoring, shifting diagnosis from population‐based averages to dynamic, individualized analysis. This review systematically examines the influence of the unique blood properties on sensor design.
Kuangyi Zou +3 more
wiley +1 more source
Chiral Lagrangian with Heavy Quark-Diquark Symmetry
, 2005 We construct a chiral Lagrangian for doubly heavy baryons and heavy mesons that is invariant under heavy quark-diquark symmetry at leading order and includes the leading O(1/m_Q) symmetry violating operators.
A. V. Manohar +6 more
core +1 more source
VIEW, EarlyView.The ICGB@Apt nanoprobes are designed to specifically recognize immune checkpoint molecules such as PD‐L1, thereby enabling precise monitoring of the progression from liver cirrhosis to HC. By binding to PD‐L1 on tumor cells, ICGB@Apt visualizes immune escape events and tumor metastasis while simultaneously reflecting the dynamic interaction between ...
Yiteng Meng +5 more
wiley +1 more source
The Visible and Near Infrared module of EChO
, 2014 The Visible and Near Infrared (VNIR) is one of the modules of EChO, the Exoplanets Characterization Observatory proposed to ESA for an M-class mission. EChO is aimed to observe planets while transiting by their suns.
Adriani, A. +13 more
core +1 more source
Post‐transcriptional regulatory networks: The dynamic interplay of RNA‐binding proteins
The FEBS Journal, EarlyView.Post‐transcriptional gene expression regulation is controlled by RNA‐binding proteins (RBPs), which influence many processes including splicing, localization, translation, and decay. Rather than acting alone, RBPs bind RNAs combinatorially, forming complex, context‐dependent regulatory networks.
Lena A. Street +2 more
wiley +1 more source
Estimate of the Hadronic Production of the Doubly Charmed Baryon $\Xi_{cc}$ under GM-VFN Scheme
, 2006 Hadronic production of the doubly charmed baryon $\Xi_{cc}$ ($\Xi^{++}_{cc}$ and $\Xi^{+}_{cc}$) is investigated under the general-mass variable-flavor-number (GM-VFN) scheme. The gluon-gluon fusion mechanism and the intrinsic charm mechanisms, i.e.
A. V. Berezhnoy +7 more
core +1 more source