Results 1 to 10 of about 13,014 (201)

Advances in targeting cyclic nucleotide phosphodiesterases

Nature Reviews Drug Discovery, 2014
Hengming Ke, Faiyaz Ahmad, Yousheng Wang   +2 more
exaly  

The Role of Cyclic Nucleotide Signaling Pathways in Cancer: Targets for Prevention and Treatment

Cancers, 2014
Gary A Piazza, Heather N Tinsley, Piazza Gary A   +2 more
exaly  

Clinical experience and follow-up with large scale single-nucleotide polymorphism–based noninvasive prenatal aneuploidy testing

American Journal of Obstetrics and Gynecology, 2014
Pe'Er Dar, Megan P Hall, Melissa Stosic   +2 more
exaly  

Aptamer nucleotide analog drug conjugates in the targeting therapy of cancers

Frontiers in Cell and Developmental Biology, 2022
Aptamers are short single-strand oligonucleotides that can form secondary and tertiary structures, fitting targets with high affinity and specificity.
Yongshu Li, Yongshu Li, Yongshu Li, Jing Zhao, Zhichao Xue, Chiman Tsang, Xiaoting Qiao, Lianhua Dong, Lianhua Dong, Huijie Li, Yi Yang, Bin Yu, Yunhua Gao, Yunhua Gao   +13 more
doaj   +3 more sources

Sequence optimization of a DNA aptamer inhibiting COVID-19 infection guided by analysis of secondary structure distribution [PDF]

Computational and Structural Biotechnology Journal
The post-SELEX optimization of nucleic acid aptamers is often hindered by conformational ambiguity, as the specific functional structure is typically unknown.
Maria Izabel Muniz, Thomas Carzaniga, Giovanni Nava, Luca Casiraghi, Davide Giana, Stefano Rocca, Alessandro Pedretti, Jessica Dellavedova, Paolo Ciana, Tommaso Bellini, Marco Buscaglia   +10 more
doaj   +2 more sources

Click Capture SELEX for the Identification of Click-Modified Aptamers Targeting Small Molecules in Solution. [PDF]

Chemistry
Using kanamycin A as a model target, we developed click‐capture SELEX to identify nucleobase‐modified aptamers capable of binding small molecules in solution. This approach enables flexible incorporation of nucleobase modifications via CuAAC, allowing the chemical properties of the aptamer to be tailored to the target molecule.
Menke P, Primo CD, Bernhardt F, Schröder A, Renzl C, Mayer G.   +5 more
europepmc   +2 more sources

The application of a modified nucleotide in aptamer selection: novel thrombin aptamers containing -(1 -pentynyl)-2′-deoxyuridine [PDF]

Nucleic Acids Research, 1994
Combinatorial libraries of nucleic acids are developing into novel sources for lead compounds in drug development. In order to diversify the pool of ss DNA sequences, we have used a modified nucleotide, 5-(1-pentynyl)-2'-deoxyuridine, in place of thymidine in a random nucleic acid library and screened this library against human thrombin. Previously, we
John A. Latham, Richard Johnson, John J. Toole   +2 more
openaire   +3 more sources

Nucleotide Bias Observed with a Short SELEX RNA Aptamer Library [PDF]

Nucleic Acid Therapeutics, 2011
Systematic evolution of ligands by exponential enrichment (SELEX) is a powerful in vitro selection process used for over 2 decades to identify oligonucleotide sequences (aptamers) with desired properties (usually high affinity for a protein target) from randomized nucleic acid libraries.
William H, Thiel, Thomas, Bair, Kristina, Wyatt Thiel, Justin P, Dassie, William M, Rockey, Craig A, Howell, Xiuying Y, Liu, Adam J, Dupuy, Lingyan, Huang, Richard, Owczarzy, Mark A, Behlke, James O, McNamara, Paloma H, Giangrande   +12 more
openaire   +2 more sources

Xeno-Nucleic Acid (XNA) 2’-Fluoro-Arabino Nucleic Acid (FANA) Aptamers to the Receptor-Binding Domain of SARS-CoV-2 S Protein Block ACE2 Binding

Viruses, 2021
The causative agent of COVID-19, SARS-CoV-2, gains access to cells through interactions of the receptor-binding domain (RBD) on the viral S protein with angiotensin-converting enzyme 2 (ACE2) on the surface of human host cells.
Irani Alves Ferreira-Bravo, Jeffrey J. DeStefano   +1 more
doaj   +1 more source

PPAI: a web server for predicting protein-aptamer interactions

BMC Bioinformatics, 2020
Background The interactions between proteins and aptamers are prevalent in organisms and play an important role in various life activities. Thanks to the rapid accumulation of protein-aptamer interaction data, it is necessary and feasible to construct an
Jianwei Li, Xiaoyu Ma, Xichuan Li, Junhua Gu   +3 more
doaj   +1 more source