Results 21 to 30 of about 13,012 (166)
Structure–Activity Relationship Study of a Potent α‐Thrombin Binding Aptamer Incorporating Hexitol Nucleotides [PDF]
Chemistry – A European Journal, 2020 AbstractThe replacement of one or more nucleotide residues in the potent α‐thrombin‐binding aptamer NU172 with hexitol‐based nucleotides has been devised to study the effect of these substitutions on the physicochemical and functional properties of the anticoagulant agent.
De Fenza, Maria +8 more
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Mature miRNAs form secondary structure, which suggests their function beyond RISC. [PDF]
PLoS ONE, 2014 The generally accepted model of the miRNA-guided RNA down-regulation suggests that mature miRNA targets mRNA in a nucleotide sequence-specific manner.
Agnieszka Belter +6 more
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Molecular Therapy: Nucleic Acids, 2021 Post-SELEX modification of DNA aptamers is an established strategy to improve their affinity or inhibitory characteristics. In this study, we examined the possibility of increasing the recognition interface between the thrombin-binding aptamer HD1 (TBA ...
Igor Smirnov +4 more
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Identification of Allosteric Nucleotide Sites of Tetramethylrhodamine-Labeled Aptamer for Noncompetitive Aptamer-Based Fluorescence Anisotropy Detection of a Small Molecule, Ochratoxin A [PDF]
Analytical Chemistry, 2013 Aptamer-based fluorescence anisotropy (FA) assay combines the advantages of affinity aptamers in good stability, easy generation, and facile labeling and the benefits of FA in homogeneous analysis, such as robustness, simplicity, and high reproducibility.
Qiang, Zhao, Qin, Lv, Hailin, Wang
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PLoS ONE, 2021 Oligonucleotide-based aptamers, which have a three-dimensional structure with a single-stranded fragment, feature various characteristics with respect to size, toxicity, and permeability.
Gwangho Lee +3 more
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DNA Aptamers Block the Receptor Binding Domain at the Spike Protein of SARS-CoV-2
Frontiers in Molecular Biosciences, 2021 DNA aptamers are versatile molecular species obtained by the folding of short single-stranded nucleotide sequences, with highly specific recognition capabilities against proteins.
Fabrizio Cleri +3 more
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Design and clinical developments of aptamer-drug conjugates for targeted cancer therapy
Biomaterials Research, 2021 Background Aptamer has been called “chemical antibody” which displays the specific affinity to target molecules compared to that of antibodies and possesses several therapeutic advantages over antibodies in terms of size, accessibility to synthesis, and ...
Do-Hun Kim +3 more
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Application of Aptamers in Virus Detection and Antiviral Therapy
Frontiers in Microbiology, 2019 Viral infections can cause serious diseases for humans and animals. Accurate and early detection of viruses is often crucial for clinical diagnosis and therapy. Aptamers are mostly single-stranded nucleotide sequences that are artificially synthesized by
Xinran Zou +7 more
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ChemBioChem, 2023 AbstractChemical modification of aptamers is an important step to improve their performance and stability in biological media. This can be performed either during their identification (mod‐SELEX) or after the in vitro selection process (post‐SELEX).
Germain Niogret +12 more
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Trends in Medical Sciences, 2021 : Targeted cancer therapy is developing rapidly according to the fact that it has been demonstrated that this type of therapy can reduce various side effects and adverse events of the commonly available cancer treatment approaches such as chemotherapy and radiotherapy.
Pouya Safarzadeh Kozani +2 more
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