Results 81 to 90 of about 12,731 (219)
Microtitre Plate Based Cell-SELEX Method
Bio-Protocol, 2018 Aptamers have emerged as a novel category in the field of bioreceptors due to their wide applications ranging from biosensing to therapeutics. Several variations of their screening process, called SELEX have been reported which can yield sequences with ...
Munish Shorie, Harmanjit Kaur
doaj +1 more source
Performing SELEX experiments in silico
The Journal of Chemical Physics, 2017 Due to the sequence-dependent nature of the elasticity of DNA, many protein-DNA complexes and other systems in which DNA molecules must be deformed have preferences for the type of DNA sequence they interact with. SELEX (Systematic Evolution of Ligands by EXponential enrichment) experiments and similar sequence selection experiments have been used ...
Wondergem, A.J. +2 more
openaire +4 more sources
Ribozyme für die RNA‐katalysierte Methylierung und Markierung von RNA
Angewandte Chemie, Volume 138, Issue 23, 1 June 2026.Ribozyme sind vielseitige Werkzeuge für die präzise Modifikation von RNA. Das Reaktionsspektrum in‐vitro‐selektierter Ribozyme reicht vom Einbau funktioneller Gruppen und Fluorophoren bis zu natürlichen RNA‐Methylierungen. Dieser Übersichtsartikel präsentiert Cofaktor‐abhängige Ribozyme für die positionsgenaue Markierung und Modifikation von RNA ...
Carolin P. M. Scheitl +1 more
wiley +1 more source
Ribozymes for RNA‐Catalyzed RNA Methylation and Labeling
Angewandte Chemie International Edition, Volume 65, Issue 23, 1 June 2026.Ribozymes are powerful tools for site‐specific RNA modification. Their activities range from installing tags and fluorophores to generating natural RNA methylations, making them valuable tools to uncover the many functions that RNA plays in nature.
Carolin P. M. Scheitl +1 more
wiley +1 more source
BiomoleculesNucleic acid aptamers, selected through the Systematic Evolution of Ligands by Exponential Enrichment (SELEX), are short nucleic acid sequences that exhibit high affinity and specificity towards diverse targets.
Liangjie Feng +8 more
doaj +1 more source
MedComm, Volume 7, Issue 6, June 2026.HA1@diABZI–HMGB1 serves as a synergistic immunomodulator for dismantling the immunosuppressive microenvironment of esophageal squamous cell carcinoma (ESCC), it integrates ESCC‐targeted recognition, HMGB1‐mediated macrophage–tumor cell bridging, and diABZI‐driven STING activation.
Chaofan Huang +10 more
wiley +1 more source
Better estimation of protein-DNA interaction parameters improve prediction of functional sites
BMC Biotechnology, 2008 Background Characterizing transcription factor binding motifs is a common bioinformatics task. For transcription factors with variable binding sites, we need to get many suboptimal binding sites in our training dataset to get accurate estimates of free ...
O'Flanagan Ruadhan A +2 more
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Protein design and RNA design: Perspectives
Quantitative Biology, Volume 14, Issue 2, June 2026.Abstract Advances in deep learning and generative modeling have transformed the landscape of protein and RNA design, enabling rapid and precise creation of novel biomolecules with tailored structures and functions. In protein design, generative deep learning frameworks now support backbone generation, sequence optimization, and joint sequence–structure
Xi Chen, Xu Dai, Peilong Lu
wiley +1 more source
Monitoring the SELEX screening by ssFABS.
, 2019 Monitoring the SELEX screening by ssFABS.
Meng Zhao (54299) +4 more
core +1 more source
VIEW, Volume 7, Issue 3, June 2026.The ICGB@Apt nanoprobes are designed to specifically recognize immune checkpoint molecules such as PD‐L1, thereby enabling precise monitoring of the progression from liver cirrhosis to HC. By binding to PD‐L1 on tumor cells, ICGB@Apt visualizes immune escape events and tumor metastasis while simultaneously reflecting the dynamic interaction between ...
Yiteng Meng +5 more
wiley +1 more source