Results 91 to 100 of about 20,710 (205)
BiomoleculesNucleic acid aptamers, selected through the Systematic Evolution of Ligands by Exponential Enrichment (SELEX), are short nucleic acid sequences that exhibit high affinity and specificity towards diverse targets.
Liangjie Feng +8 more
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Better estimation of protein-DNA interaction parameters improve prediction of functional sites
BMC Biotechnology, 2008 Background Characterizing transcription factor binding motifs is a common bioinformatics task. For transcription factors with variable binding sites, we need to get many suboptimal binding sites in our training dataset to get accurate estimates of free ...
O'Flanagan Ruadhan A +2 more
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International Journal of NanomedicineChao Cheng,1,* Minjia Sun,1– 3,* Jingjing Li,1,* Yitong Xue,1 Xia Cai,4 Jing Liu,1 Xiaolian Wang,5 Shouhong Xu,2 Youhua Xie,1 Junqi Zhang1 1MOE/NHC/CAMS Key Laboratory of Medical Molecular Virology, Shanghai Institute of Infectious Disease ...
Cheng C +9 more
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RNA Aptamers Targeting Integrin α5β1 as Probes for Cyto- and Histofluorescence in Glioblastoma
Molecular Therapy: Nucleic Acids, 2019 Nucleic acid aptamers are often referred to as chemical antibodies. Because they possess several advantages, like their smaller size, temperature stability, ease of chemical modification, lack of immunogenicity and toxicity, and lower cost of production,
Pierre Fechter +13 more
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Aptamers and SELEX in Chemistry & Biology
Chemistry & Biology, 2014 Nucleic acid aptamers, or simply aptamers, are oligonucleotides that bind specific ligands that vary from small molecules to proteins. An aptamer for a specific ligand is routinely identified through the process of systematic evolution of ligands by exponential enrichment, although some aptamers are found in nature as ligand-binding sites of special ...
Famulok, M., Mayer, G.
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NMR monitoring of the SELEX process to confirm enrichment of structured RNA
Scientific Reports, 2017 RNA aptamers are RNA molecules that bind to a target molecule with high affinity and specificity using uniquely-folded tertiary structures. RNA aptamers are selected from an RNA pool typically comprising up to 1015 different sequences generated by ...
Ryo Amano +6 more
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, 2019 Aptamers are short single-stranded oligonucleotide (DNA or RNA) molecules with the ability to bind to other molecules with high affinity and specificity. Nowadays, aptamers are used as biosensing molecules with broader applications, such as ribozymes (RNA enzyme molecules with catalytic activities); riboswitches (modulating translational activities ...
Laura Armero, Claudia Troncone Clemente
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Aptamer Screening: Current Methods and Future Trend towards Non-SELEX Approach
BiosensorsAptamers are nucleic acid sequences that specifically bind with target molecules and are vital to applications such as biosensing, drug development, disease diagnostics, etc.
Zhihui Fang +6 more
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Using Aptamers for Cancer Biomarker Discovery
Journal of Nucleic Acids, 2013 Aptamers are single-stranded synthetic DNA- or RNA-based oligonucleotides that fold into various shapes to bind to a specific target, which includes proteins, metals, and molecules.
Yun Min Chang +2 more
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Simple Methods and Rational Design for Enhancing Aptamer Sensitivity and Specificity
Frontiers in Molecular Biosciences, 2018 Aptamers are structured nucleic acid molecules that can bind to their targets with high affinity and specificity. However, conventional SELEX (Systematic Evolution of Ligands by EXponential enrichment) methods may not necessarily produce aptamers of ...
Priya Kalra +6 more
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