Results 101 to 110 of about 19,390 (205)
Using Aptamers for Cancer Biomarker Discovery
Journal of Nucleic Acids, 2013 Aptamers are single-stranded synthetic DNA- or RNA-based oligonucleotides that fold into various shapes to bind to a specific target, which includes proteins, metals, and molecules.
Yun Min Chang +2 more
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Gold Nanoparticles as a Platform for Small Molecule SELEX
, 2017 Small molecules play a significant role in a variety of applications. Current detection methods present limitations leaving an unmet need for alternative methods of detection.
Smith, McKenzie Rose
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DeepAptamer: Advancing high-affinity aptamer discovery with a hybrid deep learning model
Molecular Therapy: Nucleic AcidsOligonucleotide aptamers are typically identified through a rigorous and time-consuming process known as systematic evolution of ligands by exponential enrichment (SELEX), which requires 20 to 30 iterative rounds to eliminate non/weak binding sequences ...
Xin Yang +18 more
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, 2012 RU reached at the plateau of the association curve for all different channels of the Biacore CM5 chip with DNA isolated from various rounds of SELEX (4, 7, 10, 12 and 14) using channels coated with ß-conglutin, gliadin crude extract and simply blocked ...
Marketa Svobodova (170632) +4 more
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Recent Advances in the Optimization of Nucleic Acid Aptamers and Aptasensors
BiosensorsNucleic acid aptamers are single-stranded DNA or RNA molecules that can bind to a target with high specificity and affinity, as screened by the Systematic Evolution of Ligands by Exponential Enrichment (SELEX).
Yuan Wang, Mengyan Nie
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In vivo SELEX of bone targeting aptamer in prostate cancer bone metastasis model
, 2018 Lingxiao Chen,1,* Wei He,1,* Huichuan Jiang,1,* Longxiang Wu,1 Wei Xiong,1 Bolun Li,1 Zhihua Zhou,2 Yuna Qian3–5 1Department of Urology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China; 2School of Chemistry and Chemical ...
Wu L +7 more
core
Selection conditions in the SELEX process.
, 2015 BACE1: β-Site amyloid precursor protein cleaving enzyme 1aA blank control well was introduced for counter selection since the 4th round.Selection conditions in the SELEX process.
Huiyu Liang (531468) +9 more
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Virus–based SELEX (viro-SELEX) allows development of aptamers targeting knotty proteins.
, 2020 DoctorNucleic acid aptamers, often termed chemical antibodies, are short, single-stranded DNA or RNA molecules (20–100 nucleotides in length) with defined structures that can specifically bind to a molecular target via three-dimensional structures ...
NARAYAN, CHANDAN
core
Inelastic Electron-Pion Scattering at FNAL (SELEX) [PDF]
, 1999 We describe the analysis status of SELEX electron-pion inelastic {pi}e{yields}{pi}'e'{gamma} and {pi}e{yields}{pi}'e'{pi}{sup 0} reaction ...
M. Moinester, A. Ocherashvili and V. Steiner
core
Specific Aspects of SELEX Protocol: Different Approaches for ssDNA Generation
Methods and ProtocolsBackground: Synthetic DNA aptamers are a class of molecules with potential applications in medicine, serving as molecular sensors or ligands for targeted drug delivery. Systematic evolution of ligands by exponential enrichment (SELEX) is a technology for
Alexandr Garanin +5 more
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