DNA Aptamers in the Diagnosis and Treatment of Human Diseases
Molecules, 2015 Aptamers have a promising role in the field of life science and have been extensively researched for application as analytical tools, therapeutic agents and as vehicles for targeted drug delivery.
Qinchang Zhu +2 more
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Human umbilical cord mesenchymal stem cell-derived exosomes protect renal tubular epithelial cells against tunicamycin-induced apoptosis [PDF]
Xin yixue, 2023 Objective To investigate the role of human umbilical cord mesenchymal stem cell-derived exosomes （hUC-MSC-Exo） in the tunicamycin-induced apoptosis of renal tubular epithelial cells （HKC）.
Lei Yan, Zhan Shihuai, Shi Xiaohua, Yang Lan, Wang Jiawei, Wang Shuiliang, Zhang Shenghang
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The identification of single strand DNA aptamers which specifically bind to platelets using cell-SELEX technique [PDF]
The Iranian Journal of Veterinary Science and Technology, 2021 Aptamers are oligonucleotides that can be easily synthesized and bind to their targets with high affinity and specificity. Several aptamers specific to soluble factors of coagulation cascade have been produced, however, aptamers specific to platelet cell
Fatemeh Alemi +4 more
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Aptamers: Potential Diagnostic and Therapeutic Agents for Blood Diseases
Molecules, 2022 Aptamers are RNA/DNA oligonucleotide molecules that specifically bind to a targeted complementary molecule. As potential recognition elements with promising diagnostic and therapeutic applications, aptamers, such as monoclonal antibodies, could provide ...
Maher M. Aljohani +5 more
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PLoS ONE, 2022 BackgroundGrowth Hormone Releasing Hormone (GHRH), 44 amino acids containing hypothalamic hormone, retains the biological activity by its first 29 amino acids.
Burcu Ayhan-Sahin +4 more
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A grafting strategy for the design of improved G-quadruplex aptamers and high-activity DNAzymes. [PDF]
PLoS ONE, 2009 Nucleic acid aptamers are generally obtained by in vitro selection. Some have G-rich consensus sequences with ability to fold into the four-stranded structures known as G-quadruplexes.
Tao Li, Erkang Wang, Shaojun Dong
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Advances in Screening and Development of Therapeutic Aptamers Against Cancer Cells
Frontiers in Cell and Developmental Biology, 2021 Cancer has become the leading cause of death in recent years. As great advances in medical treatment, emerging therapies of various cancers have been developed.
Zheng Li +6 more
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Characterization of MNK1b DNA Aptamers That Inhibit Proliferation in MDA-MB231 Breast Cancer Cells
Molecular Therapy: Nucleic Acids, 2016 Elevated expression levels of eukaryotic initiation factor 4E (eIF4E) promote cancer development and progression. MAP kinase interacting kinases (MNKs) modulate the function of eIF4E through the phosphorylation that is necessary for oncogenic ...
Eva M García-Recio +6 more
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Modelling aptamers with nucleic acid mimics (NAM): From sequence to three-dimensional docking
PLoS ONE, 2022 Aptamers are single-stranded oligonucleotides, formerly evolved by Systematic Evolution of Ligands by EXponential enrichment (SELEX), that fold into functional three-dimensional structures.
Ricardo Oliveira +5 more
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Molecular Therapy: Nucleic Acids, 2016 The genetic diversity of the influenza virus hinders the use of broad spectrum antiviral drugs and favors the appearance of resistant strains. Single-stranded DNA aptamers represent an innovative approach with potential application as antiviral compounds.
Paloma Rodriguez +4 more
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