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Aptamers: Potential Diagnostic and Therapeutic Agents for Blood Diseases
Molecules, 2022 Aptamers are RNA/DNA oligonucleotide molecules that specifically bind to a targeted complementary molecule. As potential recognition elements with promising diagnostic and therapeutic applications, aptamers, such as monoclonal antibodies, could provide ...
Maher M. Aljohani +5 more
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Electrochemical Aptasensor for Detection of Dopamine [PDF]
, 2020 This work presents a proof of concept of a novel, simple, and sensitive method of detection of dopamine, a neurotransmitter within the human brain. We propose a simple electrochemical method for the detection of dopamine using a dopamine-specific aptamer
Abu-Ali, Hisham +4 more
core +1 more source
The Analyst, 2016 Nucleic acid aptamers are promising alternatives to antibodies in analytics.
Ilgu, Muslum, Nilsen-Hamilton, Marit
openaire +3 more sources
PLoS ONE, 2022 BackgroundGrowth Hormone Releasing Hormone (GHRH), 44 amino acids containing hypothalamic hormone, retains the biological activity by its first 29 amino acids.
Burcu Ayhan-Sahin +4 more
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A grafting strategy for the design of improved G-quadruplex aptamers and high-activity DNAzymes. [PDF]
PLoS ONE, 2009 Nucleic acid aptamers are generally obtained by in vitro selection. Some have G-rich consensus sequences with ability to fold into the four-stranded structures known as G-quadruplexes.
Tao Li, Erkang Wang, Shaojun Dong
doaj +1 more source
Advances in Screening and Development of Therapeutic Aptamers Against Cancer Cells
Frontiers in Cell and Developmental Biology, 2021 Cancer has become the leading cause of death in recent years. As great advances in medical treatment, emerging therapies of various cancers have been developed.
Zheng Li +6 more
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Progress on application of aptamers on food safety detection
Zhongguo shipin weisheng zazhi, 2022 Aptamers are DNA or RNA molecules that can bind to their target molecules with high affinity and specificity， and because aptamers are stable， simply synthesized and chemically modified， aptamers have become useful tools for analytical， diagnostic and ...
LI Na, WANG Ming, YUAN Jinglei
doaj +1 more source
Mechanistic insights into an engineered riboswitch: a switching element which confers riboswitch activity [PDF]
, 2010 While many different RNA aptamers have been identified that bind to a plethora of small molecules only very few are capable of acting as engineered riboswitches.
Duchardt-Ferner, Elke +6 more
core +1 more source
Characterization of MNK1b DNA Aptamers That Inhibit Proliferation in MDA-MB231 Breast Cancer Cells
Molecular Therapy: Nucleic Acids, 2016 Elevated expression levels of eukaryotic initiation factor 4E (eIF4E) promote cancer development and progression. MAP kinase interacting kinases (MNKs) modulate the function of eIF4E through the phosphorylation that is necessary for oncogenic ...
Eva M García-Recio +6 more
doaj +1 more source
Aptamer Technology and Its Applications in Bone Diseases
Cell Transplantation, 2023 Aptamers are single-stranded nucleic acids (DNA, short RNA, or other artificial molecules) produced by the Systematic Evolution of Ligands by Exponential Enrichment (SELEX) technology, which can be tightly and specifically combined with desired targets ...
Xiangzhong Liu +7 more
doaj +1 more source