Results 21 to 30 of about 41,171 (288)

Peptide aptamers define distinct EB1- and EB3-binding motifs and interfere with microtubule dynamics [PDF]

, 2014
EB1 is a conserved protein that plays a central role in regulating microtubule dynamics and organisation. It binds directly to microtubule plus ends and recruits other plus end localising proteins.
Warbrick, Emma, Ohkura, Hiroyuki, Lesniewska, Karolina   +2 more
core   +1 more source

Aptamers as Therapeutics [PDF]

Annual Review of Pharmacology and Toxicology, 2017
Aptamers are single-stranded nucleic acid molecules that bind to and inhibit proteins and are commonly produced by systematic evolution of ligands by exponential enrichment (SELEX). Aptamers undergo extensive pharmacological revision, which alters affinity, specificity, and therapeutic half-life, tailoring each drug for a specific clinical need.
Shahid M, Nimjee, Rebekah R, White, Richard C, Becker, Bruce A, Sullenger   +3 more
openaire   +2 more sources

Inhibition of the foot-and-mouth disease virus subgenomic replicon by RNA aptamers. [PDF]

, 2014
We have previously documented the inhibitory activity of RNA aptamers to the RNA-dependent RNA polymerase of foot-and-mouth disease virus (3D(pol)). Here we report their modification and use with a subgenomic replicon incorporating GFP (pGFP-PAC replicon)
Forrest, S, Lear, Z, Ryan, M., Herod, M, Forrest, S., Ryan, M, Stonehouse, N.J., Rowlands, DJ, Herod, M.R., Stonehouse, NJ, Lear, Z., Rowlands, D.J.   +11 more
core   +1 more source

Aptamer Technology and Its Applications in Bone Diseases

Cell Transplantation, 2023
Aptamers are single-stranded nucleic acids (DNA, short RNA, or other artificial molecules) produced by the Systematic Evolution of Ligands by Exponential Enrichment (SELEX) technology, which can be tightly and specifically combined with desired targets ...
Xiangzhong Liu, Jing Hu, Yu Ning, Haijia Xu, Hantao Cai, Aofei Yang, Zhengshuai Shi, Zhanghua Li   +7 more
doaj   +1 more source

Progress on application of aptamers on food safety detection

Zhongguo shipin weisheng zazhi, 2022
Aptamers are DNA or RNA molecules that can bind to their target molecules with high affinity and specificity， and because aptamers are stable， simply synthesized and chemically modified， aptamers have become useful tools for analytical， diagnostic and ...
LI Na, WANG Ming, YUAN Jinglei
doaj   +1 more source

Selection and Characterization of ssDNA Aptamers Targeting Largemouth Bass Virus Infected Cells With Antiviral Activities

Frontiers in Microbiology, 2021
Largemouth bass virus (LMBV) is one of the most devastating viral pathogens in farmed Largemouth bass. Aptamers are novel molecule probes and have been widely applied in the field of efficient therapeutic and diagnostic agents development.
Qing Yu, Mengmeng Li, Mengmeng Li, Mingzhu Liu, Mingzhu Liu, Shuaishuai Huang, Shuaishuai Huang, Gaoxue Wang, Taixia Wang, Pengfei Li, Pengfei Li, Pengfei Li   +11 more
doaj   +1 more source

Aptamers based sensing of pregnancy associated glycoproteins (PAG) of bovine for early pregnancy detection

Scientific Reports, 2021
Tosyl activated magnetic beads were used for aptamer selection against PAG- 7 and 18 proteins of bovine origin. PAG proteins were immobilized on beads with further addition of biotin tagged aptamer library.
Munna Lal Yadav, Abhishek Parashar, Nimai Charan Mahanandia, Vanya Bhushan, Sudarshan Kumar, Ashok Kumar Mohanty   +5 more
doaj   +1 more source

Aptamers and Aptamer-Coupled Biosensors to Detect Water-Borne Pathogens

Frontiers in Microbiology, 2021
Aptamers can serve as efficient bioreceptors for the development of biosensing detection platforms. Aptamers are short DNA or RNA oligonucleotides that fold into specific structures, which enable them to selectively bind to target analytes.
Mariam Saad, Mariam Saad, Sebastien P. Faucher, Sebastien P. Faucher   +3 more
doaj   +1 more source

Characterization of Aptamer-Protein Complexes by X-ray Crystallography and Alternative Approaches [PDF]

, 2012
Aptamers are oligonucleotide ligands, either RNA or ssDNA, selected for high-affinity binding to molecular targets, such as small organic molecules, proteins or whole microorganisms.
Levisson, M., Smidt, H., Ruigrok, V.J.B., Mark Levisson, Dijkstra, B.W., Hekelaar, J., Dijkstra, Bauke W., Hauke Smidt, Ruigrok, Vincent J.B.,, van der Oost, John, Bauke W. Dijkstra, Smidt, Hauke,, Hekelaar, Johan, Dijkstra, Bauke W.,, Hekelaar, Johan,, Vincent J. B. Ruigrok, Levisson, Mark,, Oost, J., van der, Levisson, Mark, Smidt, Hauke, Johan Hekelaar, John Van der Oost, van der Oost, J., Oost, John van der,, Ruigrok, Vincent J. B.   +24 more
core   +1 more source

Immobilization of Target-Bound Aptamer on Field Effect Transistor Biosensor to Improve Sensitivity for Detection of Uncharged Cortisol

Electrochemistry, 2021
Field effect transistor (FET) biosensors are capable of detecting various biomolecules, although challenges remain in the detection of uncharged molecules.
Hiroki HAYASHI, Ryo TOYAMA, Ryota TAKIBUCHI, Sho HIDESHIMA, Shigeki KUROIWA, Naoto KANEKO, Katsunori HORII, Keishi OHASHI, Toshiyuki MOMMA, Tetsuya OSAKA   +9 more
doaj   +1 more source