Results 21 to 30 of about 31,079 (257)
Aptamers and Aptamer-Coupled Biosensors to Detect Water-Borne Pathogens
Frontiers in Microbiology, 2021 Aptamers can serve as efficient bioreceptors for the development of biosensing detection platforms. Aptamers are short DNA or RNA oligonucleotides that fold into specific structures, which enable them to selectively bind to target analytes.
Mariam Saad +3 more
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Scientific Reports, 2021 Tosyl activated magnetic beads were used for aptamer selection against PAG- 7 and 18 proteins of bovine origin. PAG proteins were immobilized on beads with further addition of biotin tagged aptamer library.
Munna Lal Yadav +5 more
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Aptamers as Therapeutics [PDF]
Annual Review of Pharmacology and Toxicology, 2017 Aptamers are single-stranded nucleic acid molecules that bind to and inhibit proteins and are commonly produced by systematic evolution of ligands by exponential enrichment (SELEX). Aptamers undergo extensive pharmacological revision, which alters affinity, specificity, and therapeutic half-life, tailoring each drug for a specific clinical need.
Shahid M, Nimjee +3 more
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Aptamers: A Feasible Technology in Cancer Immunotherapy
Journal of Immunology Research, 2016 Aptamers are single-chained RNA or DNA oligonucleotides (ODNs) with three-dimensional folding structures which allow them to bind to their targets with high specificity.
M. M. Soldevilla +2 more
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Methods for Improving Aptamer Binding Affinity
Molecules, 2016 Aptamers are single stranded oligonucleotides that bind a wide range of biological targets. Although aptamers can be isolated from pools of random sequence oligonucleotides using affinity-based selection, aptamers with high affinities are not always ...
Hijiri Hasegawa +3 more
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Electrochemistry, 2021 Field effect transistor (FET) biosensors are capable of detecting various biomolecules, although challenges remain in the detection of uncharged molecules.
Hiroki HAYASHI +9 more
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Aptamers and Their Biological Applications [PDF]
Sensors, 2012 Recently, aptamers have attracted the attention of many scientists, because they not only have all of the advantages of antibodies, but also have unique merits, such as thermal stability, low cost, and unlimited applications. In this review, we present the reasons why aptamers are known as alternatives to antibodies.
Song, KM, Lee, S, Ban, C
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Biosensors, 2017 In the last years, great progress has been accomplished in the development of aptamer sensors with different transducers. In order to improve the sensitivity of these biosensors, several methodologies have been employed. In this Special Issue, the state of art and the future trends in the field of aptamer sensors have been explored.
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Pharmaceutics, 2021 Nucleic acid aptamers have attracted considerable attention as next-generation pharmaceutical agents and delivery vehicles for small molecule drugs and therapeutic oligonucleotides.
Hiro Uemachi +5 more
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Molecular Therapy: Nucleic Acids, 2023 Here, we present DNA aptamers capable of specific binding to glial tumor cells in vitro, ex vivo, and in vivo for visualization diagnostics of central nervous system tumors.
Anna S. Kichkailo +54 more
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