Results 31 to 40 of about 41,171 (288)
Biosensors, 2017 In the last years, great progress has been accomplished in the development of aptamer sensors with different transducers. In order to improve the sensitivity of these biosensors, several methodologies have been employed. In this Special Issue, the state of art and the future trends in the field of aptamer sensors have been explored.
openaire +4 more sources
Characterisation of Triple Negative Breast Cancer biomarkers identified using DNA-Aptamers
, 2023 This thesis focuses on identifying new drug targets for triple-negative breast cancer (TNBC), which is a chemotherapy-resistant and highly aggressive type of breast cancer.
MORGAN LOUISE MARSHALL (16025564)
core +1 more source
, 2016 Aptamers have been increasingly applied in biomedical field as a class of biorecognition elements that possess many advantages such as high specificity and binding affinity, easy synthesis, easy modification, small size, non-toxicity and good stability ...
Bayraç, Abdullah Tahir +3 more
core +2 more sources
Aptamers: A Feasible Technology in Cancer Immunotherapy
Journal of Immunology Research, 2016 Aptamers are single-chained RNA or DNA oligonucleotides (ODNs) with three-dimensional folding structures which allow them to bind to their targets with high specificity.
M. M. Soldevilla +2 more
doaj +1 more source
Methods for Improving Aptamer Binding Affinity
Molecules, 2016 Aptamers are single stranded oligonucleotides that bind a wide range of biological targets. Although aptamers can be isolated from pools of random sequence oligonucleotides using affinity-based selection, aptamers with high affinities are not always ...
Hijiri Hasegawa +3 more
doaj +1 more source
Pharmaceutics, 2021 Nucleic acid aptamers have attracted considerable attention as next-generation pharmaceutical agents and delivery vehicles for small molecule drugs and therapeutic oligonucleotides.
Hiro Uemachi +5 more
doaj +1 more source
Molecular Therapy: Nucleic Acids, 2023 Here, we present DNA aptamers capable of specific binding to glial tumor cells in vitro, ex vivo, and in vivo for visualization diagnostics of central nervous system tumors.
Anna S. Kichkailo +54 more
doaj +1 more source
Chemistry & Biology, 2002 A controllable, intracellular RNA aptamer could be an invaluable therapeutic or discovery reagent. A report published in this journal shows that aptamer behavior can be regulated by a small molecule, paving the way for the development of more sophisticated ligand-regulated aptamers.
openaire +2 more sources
Preliminary in vivo characterization of a theranostic aptamer: Sgc8-c- DOTA-67Ga [PDF]
, 2017 Nucleic acid aptamers can recognise their target with high affinity and specificity, and their potential as molecular imaging agents and use in theranostics are being explored.
Cerecetto, Hugo +9 more
core +1 more source
Pharmaceuticals, 2012 The use of nucleic acid derived aptamers has rapidly expanded since the introduction of SELEX in 1990. Nucleic acid aptamers have demonstrated their ability to target a broad range of molecules in ways that rival antibodies, but advances have been very ...
Ralf Landgraf, Qian Zhang
doaj +1 more source