Results 31 to 40 of about 31,079 (257)
Pharmaceuticals, 2012 The use of nucleic acid derived aptamers has rapidly expanded since the introduction of SELEX in 1990. Nucleic acid aptamers have demonstrated their ability to target a broad range of molecules in ways that rival antibodies, but advances have been very ...
Ralf Landgraf, Qian Zhang
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Acta Biomedica Scientifica, 2022 Background. Aptamers are small single-stranded DNA or RNA molecules that have an affinity for a specific target molecule. The main method of aptamers construction is the technology of systematic evolution of ligands with exponential enrichment (SELEX ...
I. S. Solovarov +4 more
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DNA Aptamers against Taiwan Banded Krait α-Bungarotoxin Recognize Taiwan Cobra Cardiotoxins
Toxins, 2016 Bungarus multicinctus α-bungarotoxin (α-Bgt) and Naja atra cardiotoxins (CTXs) share a common structural scaffold, and their tertiary structures adopt three-fingered loop motifs. Four DNA aptamers against α-Bgt have been reported previously.
Ying-Jung Chen +3 more
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Chemistry & Biology, 2002 A controllable, intracellular RNA aptamer could be an invaluable therapeutic or discovery reagent. A report published in this journal shows that aptamer behavior can be regulated by a small molecule, paving the way for the development of more sophisticated ligand-regulated aptamers.
openaire +2 more sources
Biological Procedures OnlineExosomes are increasingly recognized as important mediators of intercellular communication in cancer biology. Exosomes can be derived from cancer cells as well as cellular components in tumor microenvironment.
Yating Wu +5 more
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Aptamers: An Emerging Tool for Diagnosis and Therapeutics in Tuberculosis
Frontiers in Cellular and Infection Microbiology, 2021 Tuberculosis (TB) has been plaguing human civilization for centuries, and currently around one-third of the global population is affected with TB.
Shruti Srivastava +2 more
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Advanced Healthcare Materials, EarlyView.A multifunctional P(EDOT‐co‐EDOT‐g‐THA) dressing acts as a dynamic biointerface integrating antifouling capability, on‐demand drug delivery, and electrical stimulation. It achieves electrochemically triggered thiolated hyaluronic acid (THA) release while modulating cellular responses for wound healing application.
Jingwen Yang +8 more
wiley +1 more source
Screening and Application of DNA Aptamers for Heparin-Binding Protein
MoleculesRapid detection of heparin-binding protein (HBP) is essential for timely intervention in sepsis cases. Current detection techniques are usually antibody-based immunological methods, which have certain problems, such as complexity and slow detection, and ...
Xi Zhou +9 more
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Sensing and Bio-Sensing Research, 2021 Leukemia is a deadly cancer disease, and according to World Health Organization (WHO) data, there were 437,033 cases across the world in 2018. Early detection of this cancer is very difficult, as its symptoms are hidden and clinically invisible ...
Yuspian Nur +3 more
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Advanced Healthcare Materials, EarlyView.Mitochondria‐targeted nanotherapies emerge as a promising strategy for combating aging‐associated neurodegenerative disorders (NDs) by restoring mitochondrial function, reducing oxidative stress, and improving neuronal survival. Recent advances in nanotechnology, therapeutic delivery, and translational research are highlighted, providing insights into ...
Dnyandev G. Gadhave +8 more
wiley +1 more source