Results 11 to 20 of about 78,567 (340)
Aptamers as the Agent in Decontamination Assays (Apta-Decontamination Assays): From the Environment to the Potential Application In Vivo [PDF]
Journal of Nucleic Acids, 2017 The binding specificity and affinity of aptamers have long been harnessed as the key elements in the development of aptamer-based assays, particularly aptasensing application.
Mawethu Pascoe Bilibana +4 more
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DNA Aptamers in the Diagnosis and Treatment of Human Diseases
Molecules, 2015 Aptamers have a promising role in the field of life science and have been extensively researched for application as analytical tools, therapeutic agents and as vehicles for targeted drug delivery.
Qinchang Zhu, Ge Liu, Masaaki Kai
exaly +3 more sources
Human umbilical cord mesenchymal stem cell-derived exosomes protect renal tubular epithelial cells against tunicamycin-induced apoptosis [PDF]
Xin yixue, 2023 Objective To investigate the role of human umbilical cord mesenchymal stem cell-derived exosomes （hUC-MSC-Exo） in the tunicamycin-induced apoptosis of renal tubular epithelial cells （HKC）.
Lei Yan, Zhan Shihuai, Shi Xiaohua, Yang Lan, Wang Jiawei, Wang Shuiliang, Zhang Shenghang
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The identification of single strand DNA aptamers which specifically bind to platelets using cell-SELEX technique [PDF]
The Iranian Journal of Veterinary Science and Technology, 2021 Aptamers are oligonucleotides that can be easily synthesized and bind to their targets with high affinity and specificity. Several aptamers specific to soluble factors of coagulation cascade have been produced, however, aptamers specific to platelet cell
Fatemeh Alemi +4 more
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Aptamers and aptamer targeted delivery [PDF]
RNA Biology, 2009 When aptamers first emerged almost two decades ago, most were RNA species that bound and tagged or inhibited simple target ligands. Very soon after, the 'selectionologists' developing aptamer technology quickly realized more potential for the aptamer.
Amy C, Yan, Matthew, Levy
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Nucleic Acids Research, 2004 The aptamer database is designed to contain comprehensive sequence information on aptamers and unnatural ribozymes that have been generated by in vitro selection methods. Such data are not normally collected in 'natural' sequence databases, such as GenBank.
Jennifer F. Lee +3 more
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Aptamer Applications in Neuroscience [PDF]
Pharmaceuticals, 2021 Being the predominant cause of disability, neurological diseases have received much attention from the global health community. Over a billion people suffer from one of the following neurological disorders: dementia, epilepsy, stroke, migraine, meningitis, Alzheimer’s disease, Parkinson’s disease, multiple sclerosis, amyotrophic lateral sclerosis ...
Meric Ozturk +2 more
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International Journal of Molecular Sciences, 2017 Aptamers are short nucleic acid sequences capable of specific, high-affinity molecular binding. They are isolated via SELEX (Systematic Evolution of Ligands by Exponential Enrichment), an evolutionary process that involves iterative rounds of selection and amplification before sequencing and aptamer characterization.
Andrew Kinghorn +4 more
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Aptamer and aptamer pharmaceuticals [PDF]
SCIENTIA SINICA Chimica, 2018 Recently, molecule-based targeted therapy has achieved remarkable success in clinical, and opened up a new era particulraly in the field of cancer therapy. Monoclonal antibodies and small molecule inhibitors are two pillars of this field. Additionally, a single-strand nucleic acid molecule called “chemical antibody” has also attracted increasing ...
Ting Zheng, Ziyue Ma, Quan Du
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Aptamers in Immunotherapy [PDF]
Human Gene Therapy, 2008 Numerous nucleic acid ligands, also termed decoys or aptamer, have been developed during the past 20 years that can bind to and inhibit the activity of many proteins. The concept that nucleic acid ligands could modulate the activity of proteins emerged from basic science studies of viruses and early work in the field of gene therapy.
Claudia M, Dollins +2 more
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