Results 51 to 60 of about 41,171 (288)

Aptamers: An Emerging Tool for Diagnosis and Therapeutics in Tuberculosis

Frontiers in Cellular and Infection Microbiology, 2021
Tuberculosis (TB) has been plaguing human civilization for centuries, and currently around one-third of the global population is affected with TB.
Shruti Srivastava, Philip Raj Abraham, Sangita Mukhopadhyay   +2 more
doaj   +1 more source

Ultrasensitive Detection of Porcine Epidemic Diarrhea Virus Infections Using Multivalent DNA Nanostructure‐Enabled Lateral Flow Assay

Advanced Healthcare Materials, EarlyView.
A multivalent DNA nanostructure‐enabled lateral flow assay was developed for rapid, ultrasensitive detection of porcine epidemic diarrhea virus (PEDV) nucleocapsid protein. Designer net‐shaped DNA nanostructures (DNA‐Net) presenting PEDV‐specific aptamers achieved ~1000‐fold enhanced binding, enabling detection of viral copies with Ct ≤ 37.42 within 10
Saurabh Umrao, Akhila Naru, Dhanush Gandavadi, Mengxi Zheng, Saraswathi Lanka, Hyeongjun Cho, Chau Nguyen Minh Hoang, Jianqiang Zhang, Ying Fang, Xing Wang   +9 more
wiley   +1 more source

Hierarchical core–shell DNA condensates enable programmable information storage and encryption

Nature Communications
Utilizing DNA’s molecular programmability, massive parallelism, and minimal energy requirements, it emerges as a transformative medium for secure data storage and encryption.
Likang Chu, Liqi Wan, Haixia Wang, Peng Wang, Linyi Deng, Yuan Gao, Pei Guo, Lei He, Da Han   +8 more
doaj   +1 more source

Recent Advances in Fluorescent Nanoparticles for Stimulated Emission Depletion Imaging

Biosensors
Stimulated emission depletion (STED) microscopy, as a popular super-resolution imaging technique, has been widely used in bio-structure analysis and resolving the dynamics of biological processes beyond the diffraction limit.
Liqing Qi, Songlin Liu, Jiantao Ping, Xingxing Yao, Long Chen, Dawei Yang, Yijun Liu, Chenjing Wang, Yating Xiao, Lubin Qi, Yifei Jiang, Xiaohong Fang   +11 more
doaj   +1 more source

Applications of Aptamer-Bound Nanomaterials in Cancer Therapy

Biosensors, 2021
Cancer is still a major disease that threatens human life. Although traditional cancer treatment methods are widely used, they still have many disadvantages.
Liangxi Zhu, Jingzhou Zhao, Zhukang Guo, Yuan Liu, Hui Chen, Zhu Chen, Nongyue He   +6 more
doaj   +1 more source

Biodistribution of Novel 68Ga-Radiolabelled HER2 Aptamers in Mice [PDF]

, 2016
peer reviewedBackground: Two novel HER2 aptamers were recently selected with great potential for the in vitro diagnosis of HER2-positive cancer. The goal of this study was to examine the in vivo diagnostic potential of these HER2 aptamers. Methods: Both
Gijs, Marlies, Aerts, An M., Plenevaux, Alain, Aerts, An, Becker, Guillaume, Luxen, André, Impens, Nathalie R.E.N., Bahri, Mohamed A., Baatout, Sarah, Impens, Nathalie, Bahri, Mohamed Ali   +10 more
core   +1 more source

Kelvin Probe Force Microscopy in Bionanotechnology: Current Advances and Future Perspectives

Advanced Materials, EarlyView.
Kelvin probe force microscopy (KPFM) enables the nanoscale mapping of electrostatic surface potentials. While widely applied in materials science, its use in biological systems remains emerging. This review presents recent advances in KPFM applied to biological samples and provides a critical perspective on current limitations and future directions for
Ehsan Rahimi, Mario Palacios‐Corella, Arjan Mol, Salvador Pané, Josep Puigmartí‐Luis   +4 more
wiley   +1 more source

Intraperitoneal programming of tailored CAR macrophages via mRNA lipid nanoparticle to boost cancer immunotherapy

Nature Communications
Therapeutic strategies for peritoneal metastasis in solid tumors are urgently needed. Programming chimeric antigen receptor macrophages (CAR-Ms) in situ offers opportunities for an unmet demand.
Kedan Gu, Ting Liang, Luting Hu, Yifan Zhao, Weiyang Ying, Mengke Zhang, Yashuang Chen, Benmeng Liang, Xinrui Lin, Yanqi Zhang, Hongyu Wu, Meng Wang, Yuping Zhu, Wenxi Wang, Yu Zhang, Chao Zuo, Zhen Du, Penghui Zhang, Jia Song, Liwen Li, Xiangsheng Liu, Sitao Xie, Weihong Tan   +22 more
doaj   +1 more source

Putative Mechanisms Underlying High Inhibitory Activities of Bimodular DNA Aptamers to Thrombin

Biomolecules, 2019
Nucleic acid aptamers are prospective molecular recognizing elements. Similar to antibodies, aptamers are capable of providing specific recognition due to their spatial structure.
Elena G. Zavyalova, Valeriia A. Legatova, Rugiya Sh. Alieva, Arthur O. Zalevsky, Vadim N. Tashlitsky, Alexander M. Arutyunyan, Alexey M. Kopylov   +6 more
doaj   +1 more source

Stable Protein‐Based G‐Quadruplex‐Derived Supramolecular Bioinks as Tunable ECM‐Mimetic Constructs Assembled by Combining Non‐Covalent and Covalent Strategies

Advanced Materials, EarlyView.
Harnessing the synergistic interplay of supramolecular self‐assembly, under macromolecular crowding conditions, and enzymatic‐mediated covalent crosslinking toward a stable protein‐based G‐quadruplex‐derived supramolecular bioink. This bioinspired strategy enables the biofabrication of complex and tunable ECM‐mimetic constructs, providing a platform ...
Vera Sousa, Rita Sobreiro‐Almeida, Bart W. L. van den Bersselaar, E. W. Meijer, Ghislaine Vantomme, João Borges, João F. Mano   +6 more
wiley   +1 more source