Results 11 to 20 of about 12,731 (219)

Monitoring genomic sequences during SELEX using high-throughput sequencing: neutral SELEX. [PDF]

PLoS ONE, 2010
BACKGROUND: SELEX is a well established in vitro selection tool to analyze the structure of ligand-binding nucleic acid sequences called aptamers. Genomic SELEX transforms SELEX into a tool to discover novel, genomically encoded RNA or DNA sequences ...
Bob Zimmermann, Tanja Gesell, Doris Chen, Christina Lorenz, Renée Schroeder   +4 more
doaj   +2 more sources

Click Capture SELEX for the Identification of Click‐Modified Aptamers Targeting Small Molecules in Solution [PDF]

Chemistry – A European Journal, Volume 32, Issue 23, 16 June 2026.
Using kanamycin A as a model target, we developed click‐capture SELEX to identify nucleobase‐modified aptamers capable of binding small molecules in solution. This approach enables flexible incorporation of nucleobase modifications via CuAAC, allowing the chemical properties of the aptamer to be tailored to the target molecule.
Philipp Menke, Carmelo Di Primo, Felix Bernhardt, Alea Schröder, Christian Renzl, Günter Mayer   +5 more
wiley   +2 more sources

Capture‐SELEX of DNA Aptamers for Highly Selective Binding of Folate [PDF]

ChemBioChem, Volume 27, Issue 10, 27 May 2026.
Using capture‐SELEX, a DNA aptamer with sub‐micromolar affinity for folate was isolated, showing excellent selectivity. Using this aptamer, a light‐up fluorescent biosensor was developed for folate detection. Folate (vitamin B9) is an essential micronutrient for human health, particularly during pregnancy.
Yachen Xie, Yifan Chen, Juewen Liu
wiley   +2 more sources

Capture-SELEX: Selection Strategy, Aptamer Identification, and Biosensing Application

Biosensors, 2022
Small-molecule contaminants, such as antibiotics, pesticides, and plasticizers, have emerged as one of the substances most detrimental to human health and the environment.
Sin Yu Lam, Hill Lam Lau, Chun Kit Kwok
doaj   +2 more sources

A Mathematical Analysis of Multiple-Target Selex

Bulletin of Mathematical Biology, 2010
SELEX (Systematic Evolution of Ligands by Exponential Enrichment) is a procedure by which a mixture of nucleic acids can be fractionated with the goal of identifying those with specific biochemical activities. One combines the mixture with a specific target molecule and then separates the target-NA complex from the resulting reactions.
Seo, Yeon-Jung, Chen, Shiliang, Nilsen-Hamilton, Marit, Levine, Howard A.   +3 more
openaire   +5 more sources

Capture-SELEX: Selection of DNA Aptamers for Aminoglycoside Antibiotics [PDF]

Journal of Analytical Methods in Chemistry, 2012
Small organic molecules are challenging targets for an aptamer selection using the SELEX technology (SELEX—Systematic Evolution of Ligans by EXponential enrichment).
Regina Stoltenburg, Nadia Nikolaus, Beate Strehlitz   +2 more
doaj   +2 more sources

Imaging the coupling of terahertz radiation to a high electron mobility transistor in the near-field [PDF]

Journal of the European Optical Society-Rapid Publications, 2009
We used AlGaN/GaN high electron mobility transistors as room-temperature direct detectors of radiation at 0.15 THz from a free electron laser, hence 5 times higher than their cutoff frequency of 30 GHz.
Ortolani M., Di Gaspare A., Giovine E., Evangelisti F., Foglietti V., Doria A., Gallerano G. P., Giovenale E., Messina G., Spassovsky I., Lanzieri C., Peroni M., Cetronio A.   +12 more
doaj   +1 more source

Libraries for genomic SELEX [PDF]

Nucleic Acids Research, 1997
An increasing number of proteins are being identified that regulate gene expression by binding specific nucleic acidsin vivo. A method termed genomic SELEX facilitates the rapid identification of networks of protein-nucleic acid interactions by identifying within the genomic sequences of an organism the highest affinity sites for any protein of the ...
B S, Singer, T, Shtatland, D, Brown, L, Gold   +3 more
openaire   +2 more sources

Imaging of Neurite Network with an Anti-L1CAM Aptamer Generated by Neurite-SELEX

, 2018
Neurite outgrowth is the critical step of nervous development. Molecular probes against neurites are essential for evaluation of the nervous system development, compound neurotoxicity, and drug efficacy on nerve regeneration.
Linlin Wang (289071), Nan Zhang (46264), Xiangjun Liu (1778443), Tao Bing (407658), Ying Liu (18461), Junyan Wang (4738518), Dihua Shangguan (359783), Luyao Shen (4738515)   +7 more
core   +3 more sources

Aptamers and antibodies: rivals or allies in cancer targeted therapy?

Exploration of Targeted Anti-tumor Therapy, 2021
The goal of an efficacious cancer therapy is to specifically target diseased cells at high accuracy while sparing normal, healthy cells. Over the past three decades, immunotherapy, based on the use of monoclonal antibodies (mAbs) directed against tumor ...
Lisa Agnello, Simona Camorani, Monica Fedele, Laura Cerchia   +3 more
doaj   +1 more source