Results 21 to 30 of about 48,450 (301)
Aptamer-iRNAs as Therapeutics for Cancer Treatment
Pharmaceuticals, 2018 Aptamers are single-stranded oligonucleotides (ssDNA or ssRNA) that bind and recognize their targets with high affinity and specificity due to their complex tertiary structure.
Mario M. Soldevilla +3 more
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Aptamers and Their Biological Applications [PDF]
Sensors, 2012 Recently, aptamers have attracted the attention of many scientists, because they not only have all of the advantages of antibodies, but also have unique merits, such as thermal stability, low cost, and unlimited applications. In this review, we present the reasons why aptamers are known as alternatives to antibodies.
Song, KM, Lee, S, Ban, C
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Self-assemble gene delivery system for molecular targeting using nucleic acid aptamer. [PDF]
, 2012 We have developed a novel vector constructed with pDNA, polyethylenimine (PEI), and mucin 1 (MUC1) aptamer for tumor-targeted gene delivery. The MUC1 aptamer and non-specific aptamer were employed to coat the pDNA/PEI complexes electrostatically and ...
Mitsuru Hashida +15 more
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Aptamer-Based Traceless Multiplexed Cell Isolation Systems
, 2022 In both biomedical research and clinical cell therapy manufacturing, there is a need for cell isolation systems that recover purified cells in the absence of any selection agent.
Emmeline L. Cheng (13144842) +2 more
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A Novel PD-L1-targeting Antagonistic DNA Aptamer With Antitumor Effects
Molecular Therapy: Nucleic Acids, 2016 The PD-1/PD-L1 axis is a major pathway involved in tumor immune evasion. Here, we report the novel PD-L1 antagonizing DNA aptamer (aptPD-L1) and demonstrate an integrated pipeline that expedites therapeutic aptamer development. Aptamer can exert antibody-
Wei-Yun Lai +4 more
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Materials Today Bio, 2023 Given the dynamic nature of engineered vascular networks within biofabricated tissue analogues, it is instrumental to have control over the constantly evolving biochemical cues within synthetic matrices throughout tissue remodeling.
Deepti Rana +6 more
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Evaluation of the anti-Salmonella Aptamer using Bioinformatic Tools and ELAA Method [PDF]
Research in Molecular Medicine, 2022 Background: Identifying and measuring food pathogens and environmental samples require accurate and high-sensitivity and specific methods. In addition, Salmonella is a zoonotic bacteria that can directly cause human disease.
Fatemeh Bozorgmehr +2 more
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Biosensors, 2022 Nucleic acid aptamer-based research has focused on achieving the highest performance for bioassays. However, there are limitations in evaluating the affinity for the target analytes in these nucleic acid aptamer-based bioassays.
Yejin Park +4 more
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Biosensors, 2017 In the last years, great progress has been accomplished in the development of aptamer sensors with different transducers. In order to improve the sensitivity of these biosensors, several methodologies have been employed. In this Special Issue, the state of art and the future trends in the field of aptamer sensors have been explored.
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Molecular Docking Insight into the Label-Free Fluorescence Aptasensor for Ochratoxin A Detection
Molecules, 2023 Ochratoxin A (OTA) is the most common mycotoxin and can be found in wheat, corn and other grain products. As OTA pollution in these grain products is gaining prominence as a global issue, the demand to develop OTA detection technology has attracted ...
Hua Ye +7 more
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