Results 31 to 40 of about 48,450 (301)
Chemistry & Biology, 2002 A controllable, intracellular RNA aptamer could be an invaluable therapeutic or discovery reagent. A report published in this journal shows that aptamer behavior can be regulated by a small molecule, paving the way for the development of more sophisticated ligand-regulated aptamers.
openaire +2 more sources
Aptamer-Integrated Scaffolds for Biologically Functional DNA Origami Structures
, 2021 The manufacture of DNA origami nanostructures with highly ordered functional motifs is of great significance for biomedical applications. Here, we present a robust strategy to produce customized scaffolds with integrated aptamer sequences, which enables ...
Zhangwei Lu (3965048) +11 more
core +1 more source
Indonesian Journal of Chemistry, 2021 Inaccurate diagnoses contributes to the high mortality rate of breast cancer. Human epidermal growth factor receptor 2 (HER2) is overexpressed in breast cancer tumors at around 20–30%.
Yeni Wahyuni Hartati +5 more
doaj +1 more source
Conformational dynamics of the tetracycline-binding aptamer
, 2011 The conformational dynamics induced by ligand binding to the tetracycline-binding aptamer is monitored via stopped-flow fluorescence spectroscopy and time-correlated single photon counting experiments.
Weigand, Julia E. +10 more
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CD25-Targeted Aptamer–Drug Conjugate for the Treatment of CD25-Expressing Hematological Malignancies
PharmaceuticsBackground: CD25, the α-chain of the interleukin-2 (IL-2) receptor, is highly expressed on malignant cells and tumor-infiltrating regulatory T-cells (Tregs) in hematologic malignancies, making it an attractive therapeutic target for tumor elimination and
Sanghyeok Woo +6 more
doaj +1 more source
Aptamer-Modified Semiconductor Quantum Dots for Biosensing Applications
Sensors, 2017 Semiconductor quantum dots have attracted extensive interest in the biosensing area because of their properties, such as narrow and symmetric emission with tunable colors, high quantum yield, high stability and controllable morphology.
Lin Wen +4 more
doaj +1 more source
Asian Pacific Journal of Cancer Biology, 2016 Oligonucleotides Aptamers are single strands of DNA and RNA with the length of 20-100 nucleotides or peptides and unique three dimensional structure that is affected by nucleotide sequence. The structure exclusively influences aptamers’ bindings with its target molecule.
Yazdanpanahi, Nasrin +2 more
openaire +4 more sources
, 2010 Long-range tertiary interactions determine the three-dimensional structure of a number of metabolite-binding riboswitch RNA elements and were found to be important for their regulatory function. For the guanine-sensing riboswitch of the Bacillus subtilis
Wöhnert, Jens +3 more
core +1 more source
DNA module platform for developing colorimetric aptamer sensors
BioTechniques, 2016 Here we present a DNA module platform for developing simple aptamer sensors based on a microarray format combined with secondary structure prediction in silico.
Yasuyuki Tomita +3 more
doaj +1 more source
, 2011 We report a novel optical biosensor platform using near-infrared fluorescent single-walled carbon nanotubes (SWNTs) functionalized with target-recognizing aptamer DNA for noninvasively detecting cell-signaling molecules In real time.
Rickus, Jenna +15 more
core +1 more source