Enhancement of in vivo targeting properties of ErbB2 aptamer by chemical modification.
PLoS ONE, 2023 Aptamers have great potential for diagnostics and therapeutics due to high specificity to target molecules. However, studies have shown that aptamers are rapidly distributed and excreted from blood circulation due to nuclease degradation.
Jun Young Park +4 more
doaj +1 more source
Optical Nanosensor Architecture for Cell-Signaling Molecules Using DNA Aptamer-Coated Carbon Nanotubes [PDF]
, 2011 We report a novel optical biosensor platform using near-infrared fluorescent single-walled carbon nanotubes (SWNTs) functionalized with target-recognizing aptamer DNA for noninvasively detecting cell-signaling molecules In real time.
Rickus, Jenna +15 more
core +1 more source
Metal-ion binding and metal-ion induced folding of the adenine-sensing riboswitch aptamer domain [PDF]
, 2010 Divalent cations are important in the folding and stabilization of complex RNA structures. The adenine-sensing riboswitch controls the expression of mRNAs for proteins involved in purine metabolism by directly sensing intracellular adenine levels ...
Wöhnert, Jens +2 more
core +1 more source
Aptamers as Therapeutics [PDF]
Annual Review of Pharmacology and Toxicology, 2017 Aptamers are single-stranded nucleic acid molecules that bind to and inhibit proteins and are commonly produced by systematic evolution of ligands by exponential enrichment (SELEX). Aptamers undergo extensive pharmacological revision, which alters affinity, specificity, and therapeutic half-life, tailoring each drug for a specific clinical need.
Shahid M, Nimjee +3 more
openaire +2 more sources
Quantification of Receptor Targeting Aptamer Binding Characteristics Using Single-Molecule Spectroscopy [PDF]
, 2011 This experimental design presents a single molecule approach based on fluorescence correlation spectroscopy (FCS) for the quantification of outer membrane proteins which are receptors to an aptamer specifically designed to target the surface receptors of
Brittany Book +5 more
core +1 more source
Novel Cell type-specific aptamer-siRNA delivery system for HIV-1 therapy [PDF]
, 2007 The successful use of small interfering RNAs (siRNAs) for therapeutic purposes requires safe and efficient delivery to specific cells and tissues. Here we demonstrate cell type-specific delivery of anti-HIV siRNAs via fusion to an anti-gp120 aptamer. The
Haitang Li +4 more
core +1 more source
Aptamer-Based Cell Nucleus Imaging via Expansion Microscopy
, 2022 Expansion microscopy (ExM) is a newly developed technology in recent years that enables nanoscale imaging under conventional microscopes. Herein, we report an aptamer-based ExM imaging strategy.
Yue Sun +19 more
core +1 more source
Self-assemble gene delivery system for molecular targeting using nucleic acid aptamer. [PDF]
, 2012 We have developed a novel vector constructed with pDNA, polyethylenimine (PEI), and mucin 1 (MUC1) aptamer for tumor-targeted gene delivery. The MUC1 aptamer and non-specific aptamer were employed to coat the pDNA/PEI complexes electrostatically and ...
Mitsuru Hashida +15 more
core +1 more source
Aptamer-Based Traceless Multiplexed Cell Isolation Systems
, 2022 In both biomedical research and clinical cell therapy manufacturing, there is a need for cell isolation systems that recover purified cells in the absence of any selection agent.
Emmeline L. Cheng (13144842) +2 more
core +1 more source
Interplay of 'induced fit' and preorganization in the ligand induced folding of the aptamer domain of the guanine binding riboswitch [PDF]
, 2006 Riboswitches are highly structured elements in the 50-untranslated regions (50-UTRs) of messenger RNA that control gene expression by specifically binding to small metabolite molecules. They consist of an aptamer domain responsible for ligand binding and
Wöhnert, Jens +5 more
core +1 more source