Results 51 to 60 of about 48,450 (301)

Modular Assembly of Cell-targeting Devices Based on an Uncommon G-quadruplex Aptamer

Molecular Therapy: Nucleic Acids, 2015
Aptamers are valuable tools that provide great potential to develop cost-effective diagnostics and therapies in the biomedical field. Here, we report a novel DNA aptamer that folds into an unconventional G-quadruplex structure able to recognize and enter
Felipe Opazo, Laura Eiden, Line Hansen, Falk Rohrbach, Jesper Wengel, Jørgen Kjems, Günter Mayer   +6 more
doaj   +1 more source

Enzyme-mimic activity study of superstable and ultrasmall graphene encapsuled CoRu nanocrystal

APL Materials, 2021
Nanozymes hold huge potential in various fields, but their much lower catalytic activities than natural enzymes greatly limit their extensive applications. Recent studies indicated that an enhanced enzyme-like activity could be obtained by decreasing the
Phouphien Keoingthong, Shengkai Li, Zhaotian Zhu, Liang Zhang, Jieqiong Xu, Long Chen, Weihong Tan, Zhuo Chen   +7 more
doaj   +1 more source

Interplay of 'induced fit' and preorganization in the ligand induced folding of the aptamer domain of the guanine binding riboswitch

, 2006
Riboswitches are highly structured elements in the 50-untranslated regions (50-UTRs) of messenger RNA that control gene expression by specifically binding to small metabolite molecules. They consist of an aptamer domain responsible for ligand binding and
Wöhnert, Jens, Nasiri, Hamid Reza, Fürtig, Boris, Buck, Janina, Schwalbe, Harald (Prof. Dr.), Noeske, Jonas   +5 more
core   +1 more source

Stable Protein‐Based G‐Quadruplex‐Derived Supramolecular Bioinks as Tunable ECM‐Mimetic Constructs Assembled by Combining Non‐Covalent and Covalent Strategies

Advanced Materials, EarlyView.
Harnessing the synergistic interplay of supramolecular self‐assembly, under macromolecular crowding conditions, and enzymatic‐mediated covalent crosslinking toward a stable protein‐based G‐quadruplex‐derived supramolecular bioink. This bioinspired strategy enables the biofabrication of complex and tunable ECM‐mimetic constructs, providing a platform ...
Vera Sousa, Rita Sobreiro‐Almeida, Bart W. L. van den Bersselaar, E. W. Meijer, Ghislaine Vantomme, João Borges, João F. Mano   +6 more
wiley   +1 more source

DNA-Based Molecular Machines: Controlling Mechanisms and Biosensing Applications

Biosensors
The rise of DNA nanotechnology has driven the development of DNA-based molecular machines, which are capable of performing specific operations and tasks at the nanoscale. Benefitting from the programmability of DNA molecules and the predictability of DNA
Chunran Ma, Shiquan Li, Yuqi Zeng, Yifan Lyu   +3 more
doaj   +1 more source

Double‐Transition‐Metal MXenes: Multimetallic 2D Platforms for Next‐Generation Biomedicine

Advanced Materials, EarlyView.
The present work explores recent progress in double‐transition‐metal MXenes and focuses on their potential as multifunctional biomedical nanoplatforms whose tunable optical, electronic, mechanical, and surface properties enable imaging, theranostics, antimicrobial activity, biosensing, tissue engineering, and drug delivery.
Parsa Namakiaraghi, Mohammad Mozafari, Masoud Soroush   +2 more
wiley   +1 more source

Tetracycline aptamer-controlled regulation of pre-mRNA splicing in yeast

, 2007
Splicing of pre-mRNA is a critical step in mRNA maturation and disturbances cause several genetic disorders. We apply the synthetic tetracycline (tc)-binding riboswitch to establish a gene expression system for conditional tc-dependent control of pre ...
Weigand, Julia E., Suess, Beatrix, Weigand, Julia, Süß, Beatrix   +3 more
core   +1 more source

A Dual‐Bioresponsive and Programmable Microneedle Matrix as a Bioinspired Coupler for Orchestrating Diabetic Bone Regeneration

Advanced Materials, EarlyView.
This project developed a smart bandage‐like patch (a microneedle array) for repairing diabetic bone damage. It intelligently senses signals from infection and inflammation, then releases its medicines in a specific, timed sequence: first an antibacterial agent, then an anti‐inflammatory agent, and finally growth factors.
Yu Wang, Rui Chen, Yu Chen, Haowen Lu, Yuchen Qian, Zhiheng Gao, Zheming Shen, Xiaofei Zheng, Huilin Yang, Jun Zou, Yusen Qiao   +10 more
wiley   +1 more source

Adipocytic sclerostin loop3-LRP4 interaction required by sclerostin to impair whole-body lipid and glucose metabolism

Nature Communications
Sclerostin, which has three loops, inhibits bone formation and impairs whole-body lipid and glucose metabolism. The marketed therapeutic sclerostin antibody for postmenopausal osteoporosis (POP) mainly targeting loop2 promotes bone formation and improves
Hewen Jiang, Xiaohui Tao, Sifan Yu, Yihao Zhang, Yuan Ma, Nanxi Li, Shenghang Wang, Ning Zhang, Xin Yang, Shijian Ding, Chuanxin Zhong, Haitian Li, Zhanghao Li, Xiaoxin Wen, Huarui Zhang, Zefeng Chen, Meiheng Sun, Hang Luo, Meishen Ren, Chongguang Lei, Yuanyuan Yu, Jin Liu, Zongkang Zhang, Aiping Lyu, Hui Sheng, Dijie Li, Luyao Wang, Ge Zhang, Bao-Ting Zhang   +28 more
doaj   +1 more source

Aptamer Display on Diverse DNA Polyhedron Supports

Molecules, 2018
DNA aptamers are important tools for molecular recognition, particularly for a new generation of tools for biomedicine based on nucleic acid nanostructures.
Simon Chi-Chin Shiu, Lewis A. Fraser, Yifan Ding, Julian A. Tanner   +3 more
doaj   +1 more source