Results 61 to 70 of about 48,450 (301)

In vitro Selection and Interaction Studies of a DNA Aptamer Targeting Protein A. [PDF]

open access: yesPLoS ONE, 2015
A new DNA aptamer targeting Protein A is presented. The aptamer was selected by use of the FluMag-SELEX procedure. The SELEX technology (Systematic Evolution of Ligands by EXponential enrichment) is widely applied as an in vitro selection and ...
Regina Stoltenburg   +2 more
doaj   +1 more source

Aptamer-Based Field-Effect Transistor for Detection of Avian Influenza Virus in Chicken Serum

open access: yes, 2020
Early diagnosis of the highly pathogenic H5N1 avian influenza virus (AIV) is significant for preventing and controlling a global pandemic. However, there is no existing electrical biosensor for detecting biomarkers for AIV in clinically relevant samples ...
Yeonju Lee (644022)   +7 more
core   +1 more source

Layered Nanoporous Platforms for SERS Sensing

open access: yesAdvanced Materials Interfaces, EarlyView.
Here, we present a detailed investigation of the SERS performance of layered nanoporous metals. The controlled deposition of well‐defined, stacked porous layers enabled a systematic analysis of the effects of multimetallic systems in SERS experiments. Numerical models are also used to support the experimental findings.
Yanqiu Zou   +18 more
wiley   +1 more source

Continuously tunable multistability in DNA replication networks

open access: yesNature Communications
Multistable systems, ideally, could stabilize at any desired, switchable state within a continuous spectrum. However, conventional systems, constrained by signal-mediated mutual activation or inhibition, are limited to a finite set of discrete steady ...
Rui Zhong   +5 more
doaj   +1 more source

A DNA-Based Biosensor Assay for the Kinetic Characterization of Ion-Dependent Aptamer Folding and Protein Binding

open access: yesMolecules, 2019
Therapeutic and diagnostic nucleic acid aptamers are designed to bind tightly and specifically to their target. The combination of structural and kinetic analyses of aptamer interactions has gained increasing importance.
Irene Ponzo   +3 more
doaj   +1 more source

Label‐Free Detection of a Neurotransmitter Using an Aptamer‐Functionalized Amorphous IGZO Transistor

open access: yesAdvanced Materials Interfaces, EarlyView.
An aptamer‐functionalized amorphous IGZO thin‐film transistor enables label‐free electrical detection of the neurotransmitter serotonin under liquid‐gated operation. Stepwise surface functionalization ensures stable biomolecule integration and efficient electrostatic coupling.
Ngoc Thanh Ho   +3 more
wiley   +1 more source

Rational Truncation of Aptamer for Ultrasensitive Aptasensing of Chloramphenicol: Studies Using Bio-Layer Interferometry

open access: yesBiosensors, 2023
Aptamers are an excellent choice for the selective detection of small molecules. However, the previously reported aptamer for chloramphenicol suffers from low affinity, probably as a result of steric hindrance due to its bulky nature (80 nucleotides ...
Richa Sharma   +3 more
doaj   +1 more source

An Advanced Molecularly Imprinted Polymer‐Based Electrochemical Aptasensor for Carbendazim Detection

open access: yesAdvanced Materials Interfaces, EarlyView.
A dual‐recognition electrochemical aptasensor that integrates a molecular imprinted polymer (MIP) and an aptamer is developed for the detection of a common pesticide, carbendazim (CBZ). The resulting sensor exhibits enhanced selectivity toward CBZ over structurally similar compounds and achieves a low detection limit of 1.3 nm, demonstrating its ...
Suthira Pushparajah   +3 more
wiley   +1 more source

Interface‐Engineered Binary Framework Composites: Advancing Porous Materials for Precision Medicine

open access: yesAdvanced Materials Interfaces, EarlyView.
Binary framework composites integrate two complementary porous architectures into a unified platform, enabling multifunctional design, enhanced structural tunability, and improved physicochemical performance. By combining high surface area, ordered porosity, interfacial synergy, and versatile functionalization, these hybrid materials offer new ...
Navid Rabiee   +3 more
wiley   +1 more source

Pharmacokinetics of a Cholesterol-conjugated Aptamer Against the Hepatitis C Virus (HCV) NS5B Protein

open access: yesMolecular Therapy: Nucleic Acids, 2015
Hepatitis C virus (HCV) is the major cause of progressive liver disease such as chronic hepatitis, cirrhosis, and hepatocellular carcinoma. Previously, we reported that a 29 nucleotide-long 2’-F pyrimidine modified RNA aptamer against the HCV ...
Chang Ho Lee   +5 more
doaj   +1 more source

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