Results 61 to 70 of about 72,832 (299)

Hachimoji DNA and RNA: A genetic system with eight building blocks [PDF]

, 2019
Reported here are DNA and RNA-like systems built from eight (hachi-) nucleotide letters (-moji) that form four orthogonal pairs. This synthetic genetic biopolymer meets the structural requirements needed to support Darwinism, including a polyelectrolyte ...
Bates, Alison M., Benner, Steven A., DasGupta, Saurja, Ellington, Andrew D., Georgiadis, Millie M., Hoshika, Shuichi, Karalkar, Nilesh B., Kim, Hyo-Joong, Kim, Myong-Jung, Kim, Myong-Sang, Leal, Nicole A., Meyer, Adam J., Piccirilli, Joseph A., SantaLucia, Holly A., SantaLucia, John, Jr., Watkins, Norman E., Jr.   +15 more
core   +1 more source

Bifunctional Surfaces With Immobilized Antibodies and Bioactive Peptides Mediate Selective Capture and Proliferation of Endothelial Colony‐Forming Cells

Advanced Healthcare Materials, EarlyView.
A tunable bifunctional surface is developed by combining Fc‐binding peptides and RGD motifs to present oriented antibodies alongside integrin‐mediated signaling. The platform selectively captures endothelial colony‐forming cells while promoting their adhesion and proliferation.
Hugo A. Level, Marc‐Antoine Campeau, Mohamed A. Elkhodiry, Gaétan Laroche, Jean‐François Tanguay, Corinne A. Hoesli   +5 more
wiley   +1 more source

Aptamer‐Based Delivery Systems for VEGF and NGF Modulation in Ocular Therapies

Advanced Healthcare Materials, EarlyView.
Aptamer‐based delivery systems targeting NGF and VEGF hold significant potential for precise and sustained treatment of complex diseases affecting both the anterior and posterior segments of the eye. This review critically summarizes current strategies for NGF and VEGF delivery as well as VEGF sequestration, providing a clinical perspective on how ...
Nadine Best, Gizem Karabiyik, Gerd Geerling, Sarah Barbara Zwingelberg, Gregor Lang, Martin Humenik   +5 more
wiley   +1 more source

Adipocytic sclerostin loop3-LRP4 interaction required by sclerostin to impair whole-body lipid and glucose metabolism

Nature Communications
Sclerostin, which has three loops, inhibits bone formation and impairs whole-body lipid and glucose metabolism. The marketed therapeutic sclerostin antibody for postmenopausal osteoporosis (POP) mainly targeting loop2 promotes bone formation and improves
Hewen Jiang, Xiaohui Tao, Sifan Yu, Yihao Zhang, Yuan Ma, Nanxi Li, Shenghang Wang, Ning Zhang, Xin Yang, Shijian Ding, Chuanxin Zhong, Haitian Li, Zhanghao Li, Xiaoxin Wen, Huarui Zhang, Zefeng Chen, Meiheng Sun, Hang Luo, Meishen Ren, Chongguang Lei, Yuanyuan Yu, Jin Liu, Zongkang Zhang, Aiping Lyu, Hui Sheng, Dijie Li, Luyao Wang, Ge Zhang, Bao-Ting Zhang   +28 more
doaj   +1 more source

Aptamer Display on Diverse DNA Polyhedron Supports

Molecules, 2018
DNA aptamers are important tools for molecular recognition, particularly for a new generation of tools for biomedicine based on nucleic acid nanostructures.
Simon Chi-Chin Shiu, Lewis A. Fraser, Yifan Ding, Julian A. Tanner   +3 more
doaj   +1 more source

Applications of Graphene Quantum Dots in Biomedical Sensors [PDF]

, 2020
Due to the proliferative cancer rates, cardiovascular diseases, neurodegenerative disorders, autoimmune diseases and a plethora of infections across the globe, it is essential to introduce strategies that can rapidly and specifically detect the ultralow ...
Altintas, Zeynep, Mansuriya, Bhargav D.
core   +1 more source

Kelvin Probe Force Microscopy in Bionanotechnology: Current Advances and Future Perspectives

Advanced Materials, EarlyView.
Kelvin probe force microscopy (KPFM) enables the nanoscale mapping of electrostatic surface potentials. While widely applied in materials science, its use in biological systems remains emerging. This review presents recent advances in KPFM applied to biological samples and provides a critical perspective on current limitations and future directions for
Ehsan Rahimi, Mario Palacios‐Corella, Arjan Mol, Salvador Pané, Josep Puigmartí‐Luis   +4 more
wiley   +1 more source

Continuously tunable multistability in DNA replication networks

Nature Communications
Multistable systems, ideally, could stabilize at any desired, switchable state within a continuous spectrum. However, conventional systems, constrained by signal-mediated mutual activation or inhibition, are limited to a finite set of discrete steady ...
Rui Zhong, Yanjie Fu, Shubao Jiang, Shan Wang, Liang Yue, Weihong Tan   +5 more
doaj   +1 more source

In vitro Selection and Interaction Studies of a DNA Aptamer Targeting Protein A. [PDF]

PLoS ONE, 2015
A new DNA aptamer targeting Protein A is presented. The aptamer was selected by use of the FluMag-SELEX procedure. The SELEX technology (Systematic Evolution of Ligands by EXponential enrichment) is widely applied as an in vitro selection and ...
Regina Stoltenburg, Thomas Schubert, Beate Strehlitz   +2 more
doaj   +1 more source

Recent Progress in Optical Sensors for Biomedical Diagnostics [PDF]

, 2020
In recent years, several types of optical sensors have been probed for their aptitude in healthcare biosensing, making their applications in biomedical diagnostics a rapidly evolving subject.
Altintas, Zeynep, Pirzada, Muqsit
core   +1 more source