Results 81 to 90 of about 48,450 (301)

Aptamers in Therapeutics

open access: yesJOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH, 2016
Aptamers are single strand DNA or RNA molecules, selected by an iterative process known as Systematic Evolution of Ligands by Exponential Enrichment (SELEX). Due to various advantages of aptamers such as high temperature stability, animal free, cost effective production and its high affinity and selectivity for its target make them attractive ...
openaire   +3 more sources

Aptamer-Based Paper Strip Sensor for Detecting Vibrio fischeri

open access: yes, 2018
Aptamer-based paper strip sensor for detecting Vibrio fischeri was developed. Our method was based on the aptamer sandwich assay between whole live cells, V. fischeri and DNA aptamer probes. Following 9 rounds of Cell-SELEX and one of the negative-SELEX,
Woo-Ri Shin (4993184)   +6 more
core   +1 more source

Aptamer-Based Sensing of Small Organic Molecules by Measuring Levitation Coordinate of Single Microsphere in Combined Acoustic–Gravitational Field

open access: yes, 2020
We present aptamer-based sensing using a coupled acoustic-gravitational (CAG) field, which transduces a change in the density of a microparticle (MP) to a change in the levitation coordinate.
Akihisa Miyagawa (4789803)   +2 more
core   +1 more source

Aptamer-DNA Origami-Functionalized Solid-State Nanopores for Single-Molecule Sensing of G‑Quadruplex Formation

open access: yes, 2022
We describe the single-molecule sensing of G-quadruplex (G-q) formation in target-bound aptamers using solid-state nanopores. In order to do this, we functionalize the solid-state nanopore using DNA origami sheets incorporated with the aptamer sequence ...
Manoj M. Varma (2802064)   +4 more
core   +1 more source

Enhancing Small Molecule Sensing With Aptameric Functionalized Nano Devices

open access: yesAdvanced Materials Technologies, EarlyView.
Unveiling an ultra‐sensitive, non‐invasive neurotransmitter sensor. For the first time, a nanoscale sensor for detecting an important neurotransmitter was demonstrated using micro‐electromechanical systems (MEMS) technology. Our approach utilized field‐effect transistor (FET)‐based readout to enable pico‐molar detection of biomarkers in sweat.
Thi Thanh Ha Nguyen   +11 more
wiley   +1 more source

Integrative structural biology studies of HIV-1 reverse transcriptase binding to a high-affinity DNA aptamer

open access: yesCurrent Research in Structural Biology, 2020
The high-resolution crystal structure of HIV-1 reverse transcriptase (RT) bound to a 38-mer DNA hairpin aptamer with low pM affinity was previously described.
Steve Tuske   +11 more
doaj   +1 more source

Upcycling Compact Discs Into Ultra‐Stable, Flexible, and Stretchable Nanoporous Gold Electrodes for Enhanced Biosensing Performance

open access: yesAdvanced Materials Technologies, EarlyView.
This article highlights the development of robust and high‐performance flexible and stretchable biosensors that maintain long‐term functionality and optimal electrical conductivity under mechanical deformation, utilizing sustainable and cost‐effective manufacturing principles.
Mousa H. Aldosari, Ahyeon Koh
wiley   +1 more source

Revealing the Transmission Hologram's Refractive Index Profile Stored in a Photohydrogel: A Structural Characterization

open access: yesAdvanced Optical Materials, EarlyView.
A theoretical model is developed to visualize three‐dimensional refractive index profiles in transmission holographic gratings. In this work, it is applied to photopolymerizable hydrogels, enabling detailed analysis of the internal structure of recorded holograms and their evolution under different degradation conditions.
Belén Nieto‐Rodríguez   +4 more
wiley   +1 more source

Recent Advances in Aptamer-Based Point-of-Care Testing

open access: yesSensors
Aptamers refer to a class of oligonucleotide probes that have demonstrated remarkable capabilities beyond mere genetic coding, including the unique ability to recognize and selectively bind to specific molecular targets.
Senlin Luo   +6 more
doaj   +1 more source

Aptamer-guided extracellular vesicle theranostics in oncology

open access: yes, 2020
Aptamer-guided extracellular vesicle theranostics in ...
Y Ma (7409624)   +16 more
core  

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