Results 71 to 80 of about 53,726 (303)
Journal of Biomedical ScienceBackground Pancreatic ductal adenocarcinoma (PDAC) remains one of the deadliest cancers due to late diagnosis, early metastasis and resistance to therapy. Cancer stem cells (CSCs) have been implicated in PDAC aggressiveness and treatment failure.
Alberto Pérez-Ruiz +14 more
doaj +1 more source
Molecules, 2019 Therapeutic and diagnostic nucleic acid aptamers are designed to bind tightly and specifically to their target. The combination of structural and kinetic analyses of aptamer interactions has gained increasing importance.
Irene Ponzo +3 more
doaj +1 more source
Current Research in Structural Biology, 2020 The high-resolution crystal structure of HIV-1 reverse transcriptase (RT) bound to a 38-mer DNA hairpin aptamer with low pM affinity was previously described.
Steve Tuske +11 more
doaj +1 more source
Aptamer-Based Analysis and Manipulation of the Protein Activity in Living Cells
, 2022 Directly analyzing and precisely manipulating the activity of target proteins without altering their natural structure and expression would be essential to decoding many protein-dominant cellular processes.
Kanyu Xun +13 more
core +1 more source
Ultrathin and Flexible Organic Light‐Addressable Potentiometric Sensors
Advanced Materials Technologies, EarlyView.The first ultrathin, fully organic, and flexible light‐addressable potentiometric sensor (LAPS) is demonstrated. With a thickness of only 2.3–2.9 µm, this standalone film offers sensitivity to electrolyte potential and stable performance for over 170 days.
Ami Ichikawa +6 more
wiley +1 more source
In vitro Selection and Interaction Studies of a DNA Aptamer Targeting Protein A. [PDF]
PLoS ONE, 2015 A new DNA aptamer targeting Protein A is presented. The aptamer was selected by use of the FluMag-SELEX procedure. The SELEX technology (Systematic Evolution of Ligands by EXponential enrichment) is widely applied as an in vitro selection and ...
Regina Stoltenburg +2 more
doaj +1 more source
Advanced Materials Technologies, EarlyView.A liquid metal‐based strain‐sensing architecture to measure the deformation of a circular diaphragm against obstructed surfaces is formulated using finite element modeling and confocal imaging to establish the mechanical framework and is utilized to control diaphragm‐induced confinement on a bead array, as validated by biomolecular loading level ...
Abdullah‐Bin Siddique +4 more
wiley +1 more source
The life marker chip : potential use of aptamers against small molecules and consideration of instrument planetary protection [PDF]
, 2013 The Life Marker Chip (LMC) instrument was developed with the aim to detect evidence of life on Mars. The detection was based on an inhibition immunoassay. In this work aptamers were evaluated as potential alternative to antibodies for the LMC.
Rato, Carla Cristina Pereira Salgueiro Catarino
core +4 more sources
Aptamer-nanosilver conjugates and their antibacterial activity
, 2019 The rise of antibiotic resistance in bacteria constitutes one of the greatest emerging threats to human health that requires the urgent development of new drugs and treatment approaches.
Jennifer Soundy (4455385)
core +1 more source
Recent Advances in Light‐Addressable Electrochemistry for Spatially Resolved Applications
Advanced Materials Technologies, EarlyView.This comprehensive review highlights light‐addressable electrochemistry as a powerful tool that uses light to control localized chemical reactions on unstructured semiconductor surfaces. The work evaluates advanced strategies to optimize electrode materials for enhanced spatial resolution and stability. Furthermore, it showcases diverse applications in
Nhi Trang Vo +2 more
wiley +1 more source