Results 111 to 120 of about 23,382 (212)

Spin rotation for ballistic electron transmission induced by spin-orbit interaction

, 2002
We study spin dependent electron transmission through one- and two-dimensional curved waveguides and quantum dots with account of spin-orbit interaction.
A. Voskoboynikov, A. Voskoboynikov, Almas F. Sadreev, C.-M. Hu, E. Šimánek, E.N. Bulgakov, Evgeny N. Bulgakov, F. Mireles, K.N. Pichugin, L.I. Magarill, L.I. Magarill, P. Exner, S. Datta, T.-Z. Qian, Yu.A. Bychkov   +14 more
core   +1 more source

The Pathogenic Mechanisms of and Novel Therapies for Lamin A/C-Related Dilated Cardiomyopathy Based on Patient-Specific Pluripotent Stem Cell Platforms and Animal Models

Pharmaceuticals
Variants (pathogenic) of the LMNA gene are a common cause of familial dilated cardiomyopathy (DCM), which is characterised by early-onset atrioventricular (AV) block, atrial fibrillation and ventricular tachyarrhythmias (VTs), and progressive heart ...
Xin-Yi Wu, Yee-Ki Lee, Yee-Man Lau, Ka-Wing Au, Yiu-Lam Tse, Kwong-Man Ng, Chun-Ka Wong, Hung-Fat Tse   +7 more
doaj   +1 more source

Patient and Disease-Specific Induced Pluripotent Stem Cells for Discovery of Personalized Cardiovascular Drugs and Therapeutics. [PDF]

, 2020
Human induced pluripotent stem cells (iPSCs) have emerged as an effective platform for regenerative therapy, disease modeling, and drug discovery.
Chandy, Mark, Paik, David T, Wu, Joseph C   +2 more
core  

A Perspective on the Experimental Techniques for Studying Lamins [PDF]

, 2017
3Lamins are type V intermediate filaments that collectively form a meshwork underneath the inner nuclear membrane, called nuclear lamina. Furthermore, they are also present in the nucleoplasm.
Daniele Borin, Ilaria Pecorari, Orfeo Sbaizero   +2 more
core   +1 more source

Lamin A/C deficiency-mediated ROS elevation contributes to pathogenic phenotypes of dilated cardiomyopathy in iPSC model

Nature Communications
Mutations in the nuclear envelope (NE) protein lamin A/C (encoded by LMNA), cause a severe form of dilated cardiomyopathy (DCM) with early-onset life-threatening arrhythmias.
Hangyuan Qiu, Yaxun Sun, Xiaochen Wang, Tingyu Gong, Jun Su, Jiaxi Shen, Jingjun Zhou, Jiafeng Xia, Hao Wang, Xiangfu Meng, Guosheng Fu, Donghui Zhang, Chenyang Jiang, Ping Liang   +13 more
doaj   +1 more source

Microtubule forces drive nuclear damage in LMNA cardiomyopathy. [PDF]

Nat Cardiovasc Res
Abstract Nuclear homeostasis requires balanced forces between the cytoskeleton and the nucleus. Mutations in LMNA , which encodes lamin A/C, weaken the nuclear lamina, leading to nuclear damage and muscle disease.
Amiad Pavlov D, Heffler J, Suay-Corredera C, Dehghany M, Shen KM, Zuela-Sopilniak N, Randell R, Uchida K, Jain R, Shenoy V, Lammerding J, Prosser B.   +11 more
europepmc   +3 more sources

Epithelial stem cells In Hutchinson-Gilford progeria syndrome [PDF]

, 2015
Hutchinson-Gilford progeria syndrome (HGPS) and restrictive dermopathy (RD) are two rare genetic disorders that affect children. Complications from cardiovascular disease, including atherosclerosis, are the most common cause of death in HGPS, which ...
McKenna, Tomás
core   +1 more source

Complex phenotype linked to a mutation in exon 11 of the lamin A/C gene: Hypertrophic cardiomyopathy, atrioventricular block, severe dyslipidemia and diabetes

Revista Portuguesa de Cardiologia, 2017
The lamin A/C (LMNA) gene encodes lamins A and C, which have an important role in nuclear cohesion and chromatin organization. Mutations in this gene usually lead to the so-called laminopathies, the primary cardiac manifestations of which are dilated ...
Ana Rita G. Francisco, Inês Santos Gonçalves, Fátima Veiga, Mónica Mendes Pedro, Fausto J. Pinto, Dulce Brito   +5 more
doaj   +1 more source

DNA methylation associated with postpartum depressive symptoms overlaps findings from a genome-wide association meta-analysis of depression [PDF]

, 2019
Background Perinatal depressive symptoms have been linked to adverse maternal and infant health outcomes. The etiology associated with perinatal depressive psychopathology is poorly understood, but accumulating evidence suggests that understanding inter ...
Kinser, Patricia A., Kirkpatrick, Robert M., Lapato, Dana M., Roberson-Nay, Roxann, Webb, Bradley T., York, Timothy P.   +5 more
core   +1 more source

Hutchinson-Gilford Progeria Syndrome with G608G LMNA Mutation

Journal of Korean Medical Science, 2011
Hutchinson-Gilford progeria syndrome (HGPS) is a rare condition originally described by Hutchinson in 1886. Death result from cardiac complications in the majority of cases and usually occurs at average age of thirteen years. A 4-yr old boy had typical clinical findings such as short stature, craniofacial disproportion, alopecia, prominent scalp veins ...
Kim, Hui Kwon, Lee, Jong Yoon, Bae, Eun Ju, Oh, Phil Soo, Park, Won Il, Lee, Dong Sung, Kim, Jong-Il, Lee, Hong Jin   +7 more
openaire   +2 more sources