Results 121 to 130 of about 3,472 (172)
Olmesartan Restores LMNA Function in Haploinsufficient Cardiomyocytes
CirculationBACKGROUND: Gene mutations are responsible for a sizeable proportion of cases of heart failure. However, the number of patients with any specific mutation is small. Repositioning of existing US Food and Drug Administration–approved compounds to target specific mutations is a promising approach to efficient identification of new
Eric J. Kort +8 more
openaire +2 more sources
N of 2 Responders With LMNA-NTRK1 [PDF]
JNCI: Journal of the National Cancer Institute, 2015 Chih-Jian, Lih, Alice P, Chen
openaire +2 more sources
Myonuclear morphology is abnormal in lmna-null mice.
, 2013 DAPI staining of representative EDL and soleus myofibres from wild-type (WT) lmna+/+mice show that myonuclei are evenly distributed and have similar shape, size and heterochromatin content (a and d).
Robert B. White (355741) +9 more
core +1 more source
Location of LMNA Variants and Clinical Outcomes in Cardiomyopathy
JAMA CardiologyImportancePrior studies have suggested that patients with nonmissense (ie, truncating) variants causing LMNA cardiomyopathy have worse arrhythmic outcomes compared to those with missense variants. However, the effect of the spatial distribution of missense and truncating variants on clinical outcomes remains poorly understood.ObjectiveTo determine the ...
Bhaskaran, A. +22 more
openaire +3 more sources
LMNA‐related muscular dystrophy presenting as an inflammatory myopathy
Introduction There are overlapping features between inflammatory myopathies and muscular dystrophies, particularly laminopathies. Key features that characterize laminopathies include axial and proximal weakness, contractures, and cardiac abnormalities ...
Hart G. W. Lidov +7 more
core +1 more source
Objectives To define shared and variant-specific mechanisms underlying LMNA-associated dilated cardiomyopathy (DCM) and identify therapeutic candidates using human stem cell–based models.
Janavi Kotamarthi +13 more
core +2 more sources
Posttranslational Modifications of Lamin A/C and Cardiac Aging: A Short Review
Journal of the Practice of Cardiovascular SciencesCardiac aging is considered as natural and age-related changes in the heart, which can lead to a decline in heart function. Cardiac aging increases the risk of heart failure, atrial fibrillation, and other cardiovascular complications.
Vikas Tiwari +2 more
doaj +1 more source
Genetic variation inLMNAmodulates plasma leptin and indices of obesity in aboriginal Canadians
, 2000 Hegele, Robert A., Henian Cao, Stewart B. Harris, Bernard Zinman, Anthony J. Hanley, and Carol M. Anderson. Genetic variation in LMNA modulates plasma leptin and indices of obesity in aboriginal Canadians.
HENIAN CAO +5 more
core +1 more source
Genes misexpressed in both LMNA mutant heart and fibroblasts.
, 2013 Genes misexpressed in both LMNA mutant heart and fibroblasts.
Fida Abuisneineh (358917) +12 more
core +1 more source