Results 151 to 160 of about 22,553 (288)
A dual role for A-type lamins in DNA double-strand break repair [PDF]
, 2011 A-type lamins are emerging as regulators of nuclear organization and function. Changes in their expression are associated with cancer and mutations are linked to degenerative diseases—laminopathies.
Biehl, Kenneth J +12 more
core +2 more sources
Daily rhythm in DNA methylation and the effect of total sleep deprivation
Journal of Sleep Research, Volume 34, Issue 4, August 2025.Summary Numerous hormones and genes exhibit diurnal 24‐hr rhythms that can also be affected by sleep deprivation. Here we studied diurnal rhythms in DNA methylation under a 24‐hr sleep/wake cycle and a subsequent 29 hr of continual wakefulness (1 night of sleep deprivation).
Antti‐Jussi Ämmälä +9 more
wiley +1 more source
Aging and Altered Gravity: A Cellular Perspective
The FASEB Journal, Volume 39, Issue 13, 15 July 2025.We propose that, unlike biological aging, where Primary hallmarks initiate damage, spaceflight may trigger a feedback loop between Antagonistic and Integrative hallmarks, driving accelerated aging. Returning to 1 g restores proper signaling and breaks the cycle.
Sharon van Rijthoven +1 more
wiley +1 more source
Cancer Science, Volume 116, Issue 7, Page 2040-2046, July 2025.ABSTRACT The relationship between cancer prognosis and intratumoral microbiome has recently gained attention. Regarding lung cancer, most studies have focused on bacteria outside tumors, such as sputum or lavage fluid, with few examining intratumoral bacteria and their impact on prognosis.
Takahiro Ochi +10 more
wiley +1 more source
Stem Cell Research, 2022 LMNA-related dilated cardiomyopathy (DCM) is caused by pathogenic variants in LMNA and is characterized by left ventricular enlargement, reduced systolic function, and arrhythmia.
Chelsea Lee +5 more
doaj
Homozygous Defects in LMNA, Encoding Lamin A/C Nuclear-Envelope Proteins, Cause Autosomal Recessive Axonal Neuropathy in Human (Charcot-Marie-Tooth Disorder Type 2) and Mouse [PDF]
, 2002 Annachiara De Sandre‐Giovannoli +11 more
openalex +1 more source
Stem Cell Research, 2022 Dilated cardiomyopathy (DCM) is a refractory heart disease characterized by dilation of the left ventricle and systolic dysfunction. LMNA, the gene encoding lamin A/C (a nuclear envelope protein), is the second leading causative gene associated with ...
Yuzuno Shimoda +10 more
doaj
Identification of lamin A/C (LMNA) gene mutations in Korean patients with autosomal dominant Emery-Dreifuss muscular dystrophy and limb-girdle muscular dystrophy 1B [PDF]
, 2002 Chang‐Seok Ki +6 more
openalex +1 more source
Hutchinson-Gilford Progeria Syndrome with G608G LMNA Mutation
Journal of Korean Medical Science, 2011 Hutchinson-Gilford progeria syndrome (HGPS) is a rare condition originally described by Hutchinson in 1886. Death result from cardiac complications in the majority of cases and usually occurs at average age of thirteen years. A 4-yr old boy had typical clinical findings such as short stature, craniofacial disproportion, alopecia, prominent scalp veins ...
Won Il Park +7 more
openaire +3 more sources
Activation of sarcolipin expression and altered calcium cycling in LMNA cardiomyopathy
Biochemistry and Biophysics Reports, 2020 Cardiomyopathy caused by A-type lamins gene (LMNA) mutations (LMNA cardiomyopathy) is associated with dysfunction of the heart, often leading to heart failure. LMNA cardiomyopathy is highly penetrant with bad prognosis with no specific therapy available.
Blanca Morales Rodriguez +10 more
doaj