Results 51 to 60 of about 3,472 (172)
Advanced Science, EarlyView.Microgels enable independent control of stiffness and interstitial space, overcoming limitations of conventional 3D hydrogels. Using fragmented gelatin methacryloyl microgels, we show that stiffness does not restrict non‐metastatic breast cancer growth, contrary to bulk hydrogels, and reveal the role of adherent‐to‐suspension transition in cancer ...
Danielle Vahala +15 more
wiley +1 more source
Lmna−/−; Tg mice show improved conduction parameters compared to Lmna−/− mice by ECG analysis.
, 2012 (A) Box-and-whiskers plot of pooled Lmna+/+ PR intervals (N = 5) compared with single animal PR intervals for each of the following genetic backgrounds at 5-7 weeks of age: Lmna+/+; Tg, Lmna−/− and Lmna−/−; Tg.
Carmen Lau (143381) +13 more
core +1 more source
Integrating chemo‐mechanical cues in nano‐microscale environments for stem cell regulation
BMEMat, EarlyView.Nano/microscale control strategies, including nano/microscale materials, ligand spacings, and cell encapsulating gels, cell mechanics, integrin signaling, and biochemical cues to direct stem cell fate, tissue regeneration, and organoid engineering, enabling advanced biomedical applications through mechanoregulation at cell‐material interfaces ...
Rajendra K. Singh +5 more
wiley +1 more source
Targeted disruption of Lmna gene.
, 2013 (A) Schematic of Lmna genomic locus, targeting vector and the disrupted allele. The targeting vector had an insertion of a NeoR cassette in reverse orientation in exon 2 for positive selection, and the HSV-TK gene at the 5′ end for negative selection ...
Poonam Sehgal (382118) +4 more
core +1 more source
Activation of PDGF pathway links LMNA mutation to dilated cardiomyopathy [PDF]
, 2019 Lamin A/C (LMNA) is one of the most frequently mutated genes associated with dilated cardiomyopathy (DCM). DCM related to mutations in LMNA is a common inherited cardiomyopathy that is associated with systolic dysfunction and cardiac arrhythmias. Here we
Churko, J.M. +71 more
core +1 more source
Myonuclear degeneration in LMNA null mice
The FASEB Journal, 2008 Lamins A/C, the major constituent of the nuclear lamina, confer mechanical stability to nuclei. We examined the myonuclei of LMNA null mice at the myotendinous junctions (MTJ), the site of longitudinal force transmission from contractile proteins to extracellular proteins.
Mittelbronn M +3 more
openaire +4 more sources
The effects of sodium–glucose cotransporter 2 inhibitors on the ‘forgotten’ right ventricle
ESC Heart Failure, Volume 12, Issue 2, Page 1045-1058, April 2025.Abstract With the progress in diagnosis, treatment and imaging techniques, there is a growing recognition that impaired right ventricular (RV) function profoundly affects the prognosis of patients with heart failure (HF), irrespective of their left ventricular ejection fraction (LVEF).
Liangzhen Qu, Xueting Duan, Han Chen
wiley +1 more source
, 2013 (A) The model of wild type LMNA (residues 81−383) was built using the HHblits-generated parameters from Modeller. (B) The G232V LMNA mutant model. (C) Higher magnification of (A). (D) Higher magnification of (B).
Chia-Yang Cheng (496555) +11 more
core +1 more source
Genetic Biomarkers in the Risk Assessment of Sudden Cardiac Events: A Personalized Approach
iNew Medicine, EarlyView.Genetic insights into the risk assessment of sudden cardiac events. ABSTRACT Sudden cardiac events are the leading cause of death worldwide. Conventional risk stratification methods, which largely depend on clinical history, imaging, and electrocardiography, are usually inadequate for identifying high‐risk individuals, especially those without visible ...
Shrikant Verma +5 more
wiley +1 more source
Frontiers in Genetics, 2023 Background: Laminopathies are caused by rare alterations in LMNA, leading to a wide clinical spectrum. Though muscular dystrophy begins at early ages, disease progression is different in each patient. We investigated variability in laminopathy phenotypes
Sergi Cesar +68 more
doaj +1 more source