Results 61 to 70 of about 18,190 (215)
Integrating chemo‐mechanical cues in nano‐microscale environments for stem cell regulation
BMEMat, EarlyView.Nano/microscale control strategies, including nano/microscale materials, ligand spacings, and cell encapsulating gels, cell mechanics, integrin signaling, and biochemical cues to direct stem cell fate, tissue regeneration, and organoid engineering, enabling advanced biomedical applications through mechanoregulation at cell‐material interfaces ...
Rajendra K. Singh +5 more
wiley +1 more source
Stem Cell Research, 2022 LMNA-related dilated cardiomyopathy (DCM) is caused by pathogenic variants in LMNA and is characterized by left ventricular enlargement, reduced systolic function, and arrhythmia.
Chelsea Lee +5 more
doaj +1 more source
The effects of sodium–glucose cotransporter 2 inhibitors on the ‘forgotten’ right ventricle
ESC Heart Failure, Volume 12, Issue 2, Page 1045-1058, April 2025.Abstract With the progress in diagnosis, treatment and imaging techniques, there is a growing recognition that impaired right ventricular (RV) function profoundly affects the prognosis of patients with heart failure (HF), irrespective of their left ventricular ejection fraction (LVEF).
Liangzhen Qu, Xueting Duan, Han Chen
wiley +1 more source
Lmna−/−; Tg mice display improved contractile function compared to Lmna−/− littermates.
, 2012 (A) Representative echocardiograms of Lmna−/−, Lmna−/−; Tg, and control littermates. (B) Normalized left ventricular end-systolic diameter (LVESD) measurements are increased in Lmna−/− hearts compared to control hearts and are improved in Lmna−/−; Tg ...
Carmen Lau (143381) +13 more
core +1 more source
The Broad Spectrum of LMNA Cardiac Diseases: From Molecular Mechanisms to Clinical Phenotype
, 2020 Mutations of Lamin A/C gene (LMNA) cause laminopathies, a group of disorders associated with a wide spectrum of clinically distinct phenotypes, affecting different tissues and organs.
Silvia Crasto +5 more
core +1 more source
Genetic Biomarkers in the Risk Assessment of Sudden Cardiac Events: A Personalized Approach
iNew Medicine, EarlyView.Genetic insights into the risk assessment of sudden cardiac events. ABSTRACT Sudden cardiac events are the leading cause of death worldwide. Conventional risk stratification methods, which largely depend on clinical history, imaging, and electrocardiography, are usually inadequate for identifying high‐risk individuals, especially those without visible ...
Shrikant Verma +5 more
wiley +1 more source
Myonuclear degeneration in LMNA null mice
The FASEB Journal, 2008 Lamins A/C, the major constituent of the nuclear lamina, confer mechanical stability to nuclei. We examined the myonuclei of LMNA null mice at the myotendinous junctions (MTJ), the site of longitudinal force transmission from contractile proteins to extracellular proteins.
Mittelbronn M +3 more
openaire +4 more sources
LMNA persists and colocalizes with the spindle apparatus during metaphase in LmnaDhe/+ cells.
, 2013 (A–F) Immunodetection of Lamin A (green;A,B,E,F) and α-Tubulin (red; C–F) in Lmna+/+(A,C,E) and LmnaDhe/+ (B,D,F) fibroblasts. Labeling indicates persistence of Lamin A in mitotic cells and colocalization with α-Tubulin during metaphase of mutant cells ...
Michelle Curtain (354067) +3 more
core +1 more source
Scientific ReportsMutations in LMNA, which encodes the nuclear envelope protein lamin A/C, cause laminopathies that frequently present as dilated cardiomyopathy (DCM). We investigated whether re-expression of lamin A in cardiomyocytes can rescue the severe phenotype of ...
Miho Izawa +9 more
doaj +1 more source
Targeted disruption of Lmna gene.
, 2013 (A) Schematic of Lmna genomic locus, targeting vector and the disrupted allele. The targeting vector had an insertion of a NeoR cassette in reverse orientation in exon 2 for positive selection, and the HSV-TK gene at the 5′ end for negative selection ...
Poonam Sehgal (382118) +4 more
core +1 more source