Results 1 to 10 of about 27,778 (168)

A deep learning method for replicate-based analysis of chromosome conformation contacts using Siamese neural networks

Nature Communications, 2023
The organisation of the genome in nuclear space is an important frontier of biology. Chromosome conformation capture methods such as Hi-C and Micro-C produce genome-wide chromatin contact maps that provide rich data containing quantitative and ...
Ediem Al-jibury, James W. D. King, Ya Guo, Boris Lenhard, Amanda G. Fisher, Matthias Merkenschlager, Daniel Rueckert   +6 more
doaj   +1 more source

Manufacturing Resilience during the Coronavirus Pandemic: On the investigation Manufacturing Processes Agility

European Journal of Social Impact and Circular Economy, 2020
The unprecedented events that worldwide population experienced during year 2020 due to the COVID-19 pandemic, resulted in the formation of numerous challenges across the majority of aspects of every day life.
Panagiotis Stavropoulos, Alexios Papacharalampopoulos, Konstantinos Tzimanis, Andreas Lianos   +3 more
doaj   +1 more source

An extended generalized effective stress for active clays [PDF]

E3S Web of Conferences, 2020
An effective stress concept for active clays is formulated to improve the modelling of these materials under a variety of environmental conditions.
Tuttolomondo Angelica, Ferrari Alessio, Laloui Lyesse   +2 more
doaj   +1 more source

Evaluating $$\hbox {CO}_2$$ CO 2 breakthrough in a shaly a caprock material: a multi-scale experimental approach

Scientific Reports, 2022
The potential of underground $$\hbox {CO}_2$$ CO 2 storage relies on the sealing efficiency of an overlaying caprock that acts as a geological barrier.
Eleni Stavropoulou, Lyesse Laloui
doaj   +1 more source

Endogenous bioluminescent reporters reveal a sustained increase in utrophin gene expression upon EZH2 and ERK1/2 inhibition

Communications Biology, 2023
With the long-term goal of finding therapeutic options for Duchenne muscular dystrophy, a mouse model enabling simultaneous visualisation of Dmd and Utrn is described and inhibitors of PRC2 and ERK1/2 identified to increase utrophin expression.
Hannah J. Gleneadie, Beatriz Fernandez-Ruiz, Alessandro Sardini, Mathew Van de Pette, Andrew Dimond, Rab K. Prinjha, James McGinty, Paul M. W. French, Hakan Bagci, Matthias Merkenschlager, Amanda G. Fisher   +10 more
doaj   +1 more source

Development of an Electrochemical Battery Model and Its Parameters Identification Tool

International Journal of Automotive Engineering, 2012
This paper describes the steps performed in the development of a lumped model of electrochemical battery, as well as its corresponding parameter identification assistant tool and the first results obtained.
Hafsaoui Julien, Scordia Julien, Sellier Franck, Aubret Philippe   +3 more
doaj   +1 more source

Springback Prediction of Sandwich Panel Using Machine Learning Methods [PDF]

Mechanics of Advanced Composite Structures, 2023
The purpose of this paper is to obtain a model that quickly predicts springback in the three-point bending process of steel / PUR / steel sandwich panels. Firstly, based on the finite element simulation, the springback behavior for different punch radius,
Raja Ouled Ahmed Ben Ali, Sami Chatti
doaj   +1 more source

Targeting senescence as an anticancer therapy

Molecular Oncology, 2022
Cellular senescence is a stress response elicited by different molecular insults. Senescence results in cell cycle exit and is characterised by multiple phenotypic changes such as the production of a bioactive secretome. Senescent cells accumulate during
Laura Bousset, Jesús Gil
doaj   +1 more source

Identifying the Risks of LM Agents with an LM-Emulated Sandbox

CoRR, 2023
Recent advances in Language Model (LM) agents and tool use, exemplified by applications like ChatGPT Plugins, enable a rich set of capabilities but also amplify potential risks - such as leaking private data or causing financial losses. Identifying these risks is labor-intensive, necessitating implementing the tools, setting up the environment for each
Yangjun Ruan, Honghua Dong, Andrew Wang, Silviu Pitis, Yongchao Zhou, Jimmy Ba, Yann Dubois, Chris J. Maddison, Tatsunori Hashimoto   +8 more
openaire   +3 more sources

LUMI-PCR: an Illumina platform ligation-mediated PCR protocol for integration site cloning, provides molecular quantitation of integration sites

Mobile DNA, 2020
Background Ligation-mediated PCR protocols have diverse uses including the identification of integration sites of insertional mutagens, integrating vectors and naturally occurring mobile genetic elements.
Joanna C. Dawes, Philip Webster, Barbara Iadarola, Claudia Garcia-Diaz, Marian Dore, Bruce J. Bolt, Hamlata Dewchand, Gopuraja Dharmalingam, Alex P. McLatchie, Jakub Kaczor, Juan J. Caceres, Alberto Paccanaro, Laurence Game, Simona Parrinello, Anthony G. Uren   +14 more
doaj   +1 more source