Results 141 to 150 of about 2,585 (164)

Absence of digit tip regeneration in Lmx1b-deficient nailless digits suggests a role for Lmx1b distinct from patterning

2023
Trabajo presentado en el 19th International Congress of Developmental Biology, celebrado en Guia (Portugal) del 16 al 20 de octubre de 2022.
Castilla-Ibeas, Alejandro, Zdral, Sofía, Galán, Laura, Haro, Endika, Allou, Lila, Campa, Víctor M., Icardo, Jose M., Mundlos, Stefan, Oberg, Kerby C., Ros, María A.   +9 more
openaire   +1 more source

Identification and characterization of LMX1B target genes

2016
Mutationen im LMX1B Gen sind mit einer autosomal-dominanten Erkrankung namens Nagel-Patella-Syndrom verbunden, die Gliedmaßen, Augen, Gehirn und Nieren beeinflusst. Hauptziele von LMX1B in den Nieren sind die Fussfortsätze und Schlitzmembran der Podozyten.
openaire   +2 more sources

Deciphering Lmx1b regulation during development and evolution

2023
Trabajo presentado en la 16th International Conference on Limb Development, regeneration, and evolution, celebrada en Cambridge (Estados Unidos) del 08 al 11 de agosto de 2022.
Zdral, Sofía, Castilla-Ibeas, Alejandro, Naranjo Duran, Silvia, Mate, Irene, Juliá, Miguel, Galán, Laura, Tena, Juan J., Ros, María A.   +7 more
openaire   +1 more source

LMX1B and the Nail Patella Syndrome

2008
Abstract Nail patella syndrome (NPS) is a dominantly inherited skeletal malformation syndrome. Patients have characteristic features including nail and patella hypoplasia, elbow and knee deformities, nephropathy, and ocular defects. The condition is characterized by high penetrance, variable expressivity, and signi)cant intrafamilial ...
Roy Morello, Jennifer N Lennington,, Brendan Lee   +2 more
openaire   +1 more source

Digit tip regeneration: role of Lmx1b

2023
Trabajo presentado en ISRB Webinars, celebrado en modalidad virtual el 06 de diciembre de 2022.
openaire   +1 more source

Regulation of the actin cytoskeleton in podocytes by the transcription factor LMX1B

2020
Mutations of LMX1B lead to the hereditary disease NPS, which is associated with renal symptoms (Witzgall, 2017). Within the kidney, the transcription factor LMX1B is exclusively expressed in podocytes and plays an essential role in the maturation and maintenance of the cell. Previous studies revealed not only the putative Lmx1b target genes Abra, Arl4c
openaire   +2 more sources

LMX1B and the Nail-Patella Syndrome

2016
Philippe M. Campeau, Nadejda A. Bespalova, Brendan H. Lee   +2 more
openaire   +1 more source

Transcription Factor Lmx1b Negatively Regulates Osteoblast Differentiation and Bone Formation

International Journal of Molecular Sciences, 2022
Jeong-Tae Koh, Inyoung Kim, Semun Seong   +2 more
exaly  

Identification of a Novel Missense Mutation in the LMX1B Gene

We descovered a family with nial and patella dysformation. To further investigate the desease, whole exome sequencing was carried out. We found a novel missence muation on LMX1B gene, which was associated with nail-patella syndrome. So we upload the consequence to help the diagnose and identification of this disease.
openaire   +1 more source

Lmx1b transcriptional regulation in limb development

Peer ...
Zdral, Sofía, Mate, Irene, Castilla-Ibeas, Alejandro, Galán, Laura, Oberg, Kerby C., Ros, María A.   +5 more
openaire   +1 more source