Results 161 to 170 of about 3,237 (188)

The LIM-homeodomain transcription factor LMX1B regulates expression of NF-kappa B target genes

Experimental Cell Research, 2009
LMX1B is a LIM-horneodomain transcription factor essential for development. Putative LMX1B target genes have been identified through mouse gene targeting studies, but their identity as direct LMX1B targets remains hypothetical. We describe here the first
Anne Rascle, Ralph Witzgall
exaly   +2 more sources

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The signaling pathways of LMX1B and its role in glomerulosclerosis

Journal of Receptor and Signal Transduction Research, 2012
LMX1B, a developmental LIM-homeodomain transcription factor, is widely expressed in vertebrate embryos, and it takes part in the development of diverse structures such as limbs, kidneys, eyes, brains, etc. LMX1B contributes to transcriptional regulation of glomerular basement membrane (GBM) collagen expression by podocytes.
Yuanhan Qin, Tian-Biao Zhou
exaly   +3 more sources

Detection of genes regulated by Lmx1b during limb dorsalization [PDF]

Development Growth and Differentiation, 2012
Lmx1b is a homeodomain transcription factor that regulates dorsal identity during limb development. Lmx1b knockout (KO) mice develop distal ventral–ventral limbs. Although induction of Lmx1b is linked to Wnt7a expression in the dorsal limb ectoderm, the downstream targets of Lmx1b that accomplish limb dorsalization are unknown.
Kerby C Öberg
exaly   +3 more sources

Lmx1b activation in axolotl limb regeneration

Developmental Dynamics, 2022
AbstractBackgroundAxolotls can regenerate their limbs. In their limb regeneration process, developmental genes are re‐expressed and reorganize the developmental axes, in which the position‐specific genes are properly re‐expressed. However, how such position specificity is reorganized in the regeneration processes has not been clarified. To address this
Sakiya Yamamoto, Rena Kashimoto, Saya Furukawa, Ayaka Ohashi, Akira Satoh   +4 more
openaire   +2 more sources

Lmx1b‐dependent Activity of an Associated Enhancer Suggests Lmx1b Autoregulation

The FASEB Journal, 2017
Introduction Lmx1b is a homeobox transcription factor vital for proper limb dorsalization, as well as development of structures in the kidney, brain and eye. Within the developing limb bud, expression of Lmx1b is limited to the dorsal mesoderm.
Lauren A. Ivey, Endika Haro, Charmaine U. Pira, Kerby C. Oberg   +3 more
openaire   +1 more source

Lmx1b is essential for the development of serotonergic neurons

Nature Neuroscience, 2003
The specification and differentiation of serotonergic (5-HT) neurons require both extrinsic signaling molecules and intrinsic transcription factors to work in concert or in cascade. Here we identify the genetic cascades that control the specification and differentiation of 5-HT neurons in mice.
Yu-Qiang, Ding, Ulrika, Marklund, Wenlin, Yuan, Jun, Yin, Lauren, Wegman, Johan, Ericson, Evan, Deneris, Randy L, Johnson, Zhou-Feng, Chen   +8 more
openaire   +2 more sources

Identification of genes controlled by LMX1B in the developing mouse limb bud

Developmental Dynamics, 2008
AbstractIn the developing limb, dorsal–ventral patterning is controlled by the transcription factor LMX1B, expressed in the dorsal mesenchyme. Loss of Lmx1b function in mice or humans results in the loss of dorsal limb structures and Nail–Patella syndrome, but the effectors through which LMX1B controls limb patterning are virtually unknown.
Artur Kania
exaly   +3 more sources

Combined TSC1 and LMX1B mutations in a single patient

Clinical Dysmorphology, 2014
Tuberous sclerosis complex (TSC) and nail-patella syndrome (NPS) are autosomal dominant pleiotropic disorders with full penetrance that can both involve kidneys. TSC1 and NPS genes are located on chromosome 9q3. In a large family with the two disorders with two novel frameshift TSC1 and LMX1B mutations, we describe the phenotypes.
Ola, Khalifa, Nadia, Al-Sakati, Khalid, Al-Mane, Ameera, Balobaid, Zuhair N, Al-Hassnan   +4 more
openaire   +2 more sources

Identification of genes controlled by LMX1B in E13.5 mouse limbs

Developmental Dynamics, 2010
AbstractDuring limb development, the dorsal limb mesenchyme expression of the transcription factor LMX1B is required for dorsoventral limb patterning. In mice, Lmx1b mutations result in the mirror‐image duplication of ventral limb structures and loss of dorsal limb structures.
Artur Kania
exaly   +3 more sources

Identification of LMX1B as a novel oncogene in human ovarian cancer [PDF]

Oncogene, 2013
Ovarian cancers are thought to result from the accumulation of multiple genetic aberrations that transform ovarian and/or fallopian tube surface epithelial cells, allowing for their abnormal growth, proliferation and metastasis. In the report presented here, we carried out genome-wide copy-number analysis using comparative genomic hybridization on a ...
S Orsulic, M J Birrer, G Mohapatra
exaly   +3 more sources