Results 171 to 180 of about 4,807 (209)

Innovations in spinal cord cell type heterogeneity across vertebrate evolution

Ignatyev Y, Papadopoulos S, Soretić M, Yeung J, Lin T, Tanaka EM, Peshkin L, Levine AJ, Gabitto MI, Sweeney LB.   +9 more
europepmc   +1 more source

Correction: A Dominant-Negative Mutation of Mouse Lmx1b Causes Glaucoma and Is Semi-lethal via LBD1-Mediated Dimerisation

PLoS Genetics, 2014
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Renal phenotype in heterozygous Lmx1b knockout mice (Lmx1b +/−) after unilateral nephrectomy

Transgenic Research, 2007
The nail-patella syndrome (NPS) is a rare autosomal-dominant disorder which is caused by loss-of-function mutations in the transcription factor LMX1B. NPS is characterized by dysplastic nails, absent or hypoplastic patellae, minor skeletal abnormalities and nephropathy (in 20-40% of the cases), which is the most severe aspect of the disorder.
Sabine Endele, Kerstin Amann, Bernd Klanke   +2 more
exaly   +3 more sources

Detection of genes regulated by Lmx1b during limb dorsalization [PDF]

Development Growth and Differentiation, 2012
Lmx1b is a homeodomain transcription factor that regulates dorsal identity during limb development. Lmx1b knockout (KO) mice develop distal ventral–ventral limbs. Although induction of Lmx1b is linked to Wnt7a expression in the dorsal limb ectoderm, the downstream targets of Lmx1b that accomplish limb dorsalization are unknown.
Jennifer M Feenstra, Charmaine U Pira, Kerby C Öberg   +2 more
exaly   +3 more sources

The signaling pathways of LMX1B and its role in glomerulosclerosis

Journal of Receptor and Signal Transduction Research, 2012
LMX1B, a developmental LIM-homeodomain transcription factor, is widely expressed in vertebrate embryos, and it takes part in the development of diverse structures such as limbs, kidneys, eyes, brains, etc. LMX1B contributes to transcriptional regulation of glomerular basement membrane (GBM) collagen expression by podocytes.
Tian-Biao Zhou, Yuan-Han Qin
exaly   +3 more sources

Lmx1b activation in axolotl limb regeneration

Developmental Dynamics, 2022
AbstractBackgroundAxolotls can regenerate their limbs. In their limb regeneration process, developmental genes are re‐expressed and reorganize the developmental axes, in which the position‐specific genes are properly re‐expressed. However, how such position specificity is reorganized in the regeneration processes has not been clarified. To address this
Sakiya Yamamoto, Rena Kashimoto, Saya Furukawa, Ayaka Ohashi, Akira Satoh   +4 more
openaire   +2 more sources

Lmx1b is essential for the development of serotonergic neurons

Nature Neuroscience, 2003
The specification and differentiation of serotonergic (5-HT) neurons require both extrinsic signaling molecules and intrinsic transcription factors to work in concert or in cascade. Here we identify the genetic cascades that control the specification and differentiation of 5-HT neurons in mice.
Yu-Qiang, Ding, Ulrika, Marklund, Wenlin, Yuan, Jun, Yin, Lauren, Wegman, Johan, Ericson, Evan, Deneris, Randy L, Johnson, Zhou-Feng, Chen   +8 more
openaire   +2 more sources

Lmx1b‐dependent Activity of an Associated Enhancer Suggests Lmx1b Autoregulation

The FASEB Journal, 2017
Introduction Lmx1b is a homeobox transcription factor vital for proper limb dorsalization, as well as development of structures in the kidney, brain and eye. Within the developing limb bud, expression of Lmx1b is limited to the dorsal mesoderm.
Lauren A. Ivey, Endika Haro, Charmaine U. Pira, Kerby C. Oberg   +3 more
openaire   +1 more source

Limb and kidney defects in Lmx1b mutant mice suggest an involvement of LMX1B in human nail patella syndrome

Nature Genetics, 1998
Dorsal-ventral limb patterning in vertebrates is thought to be controlled by the LIM-homeodomain protein Lmx1b which is expressed in a spatially and temporally restricted manner along the dorsal-ventral limb axis. Here we describe the phenotype resulting from targeted disruption of Lmx1b.
Chen H., Lun Y., Ovchinnikov D., Kokubo H., Oberg K.C., Pepicelli C.V., Gan L., Lee B., Johnson R.L.   +8 more
openaire   +5 more sources