Results 171 to 180 of about 4,772 (187)

Lmx1b‐dependent Activity of an Associated Enhancer Suggests Lmx1b Autoregulation

The FASEB Journal, 2017
Introduction Lmx1b is a homeobox transcription factor vital for proper limb dorsalization, as well as development of structures in the kidney, brain and eye. Within the developing limb bud, expression of Lmx1b is limited to the dorsal mesoderm.
Lauren A. Ivey, Endika Haro, Charmaine U. Pira, Kerby C. Oberg   +3 more
openaire   +1 more source

Limb and kidney defects in Lmx1b mutant mice suggest an involvement of LMX1B in human nail patella syndrome

Nature Genetics, 1998
Dorsal-ventral limb patterning in vertebrates is thought to be controlled by the LIM-homeodomain protein Lmx1b which is expressed in a spatially and temporally restricted manner along the dorsal-ventral limb axis. Here we describe the phenotype resulting from targeted disruption of Lmx1b.
Chen H., Lun Y., Ovchinnikov D., Kokubo H., Oberg K.C., Pepicelli C.V., Gan L., Lee B., Johnson R.L.   +8 more
openaire   +3 more sources

Combined TSC1 and LMX1B mutations in a single patient

Clinical Dysmorphology, 2014
Tuberous sclerosis complex (TSC) and nail-patella syndrome (NPS) are autosomal dominant pleiotropic disorders with full penetrance that can both involve kidneys. TSC1 and NPS genes are located on chromosome 9q3. In a large family with the two disorders with two novel frameshift TSC1 and LMX1B mutations, we describe the phenotypes.
Ola, Khalifa, Nadia, Al-Sakati, Khalid, Al-Mane, Ameera, Balobaid, Zuhair N, Al-Hassnan   +4 more
openaire   +2 more sources

Lmx1b is essential for the development of serotonergic neurons

Nature Neuroscience, 2003
The specification and differentiation of serotonergic (5-HT) neurons require both extrinsic signaling molecules and intrinsic transcription factors to work in concert or in cascade. Here we identify the genetic cascades that control the specification and differentiation of 5-HT neurons in mice.
Yu-Qiang, Ding, Ulrika, Marklund, Wenlin, Yuan, Jun, Yin, Lauren, Wegman, Johan, Ericson, Evan, Deneris, Randy L, Johnson, Zhou-Feng, Chen   +8 more
openaire   +2 more sources

The signaling pathways of LMX1B and its role in glomerulosclerosis

Journal of Receptors and Signal Transduction, 2012
LMX1B, a developmental LIM-homeodomain transcription factor, is widely expressed in vertebrate embryos, and it takes part in the development of diverse structures such as limbs, kidneys, eyes, brains, etc. LMX1B contributes to transcriptional regulation of glomerular basement membrane (GBM) collagen expression by podocytes.
Tian-Biao, Zhou, Yuan-Han, Qin
openaire   +2 more sources

Deciphering Lmx1b regulation during development and evolution

2023
Trabajo presentado en la 16th International Conference on Limb Development, regeneration, and evolution, celebrada en Cambridge (Estados Unidos) del 08 al 11 de agosto de 2022.
Zdral, Sofía, Castilla-Ibeas, Alejandro, Naranjo Duran, Silvia, Mate, Irene, Juliá, Miguel, Galán, Laura, Tena, Juan J., Ros, María A.   +7 more
openaire   +1 more source

Identification and characterization of LMX1B target genes

2016
Mutationen im LMX1B Gen sind mit einer autosomal-dominanten Erkrankung namens Nagel-Patella-Syndrom verbunden, die Gliedmaßen, Augen, Gehirn und Nieren beeinflusst. Hauptziele von LMX1B in den Nieren sind die Fussfortsätze und Schlitzmembran der Podozyten.
openaire   +2 more sources

Dopaminergic control of autophagic-lysosomal function implicates Lmx1b in Parkinson's disease

Nature Neuroscience, 2015
The role of developmental transcription factors in maintenance of neuronal properties and in disease remains poorly understood. Lmx1a and Lmx1b are key transcription factors required for the early specification of ventral midbrain dopamine (mDA) neurons.
Ariadna, Laguna, Nicoletta, Schintu, André, Nobre, Alexandra, Alvarsson, Nikolaos, Volakakis, Jesper Kjaer, Jacobsen, Marta, Gómez-Galán, Elena, Sopova, Eliza, Joodmardi, Takashi, Yoshitake, Qiaolin, Deng, Jan, Kehr, Johan, Ericson, Per, Svenningsson, Oleg, Shupliakov, Thomas, Perlmann   +15 more
openaire   +2 more sources

Digit tip regeneration: role of Lmx1b

2023
Trabajo presentado en ISRB Webinars, celebrado en modalidad virtual el 06 de diciembre de 2022.
openaire   +1 more source

Role of Lmx1b and Wnt1 in mesencephalon and metencephalon development

Development, 2002
The isthmus is the organizing center for the tectum and cerebellum. Fgf8 and Wnt1 are secreted molecules expressed around the isthmus. The function of Fgf8 has been well analyzed, and now accepted as the most important organizing signal. Involvement of Wnt1 in the isthmic organizing activity was suggested by analysis of Wnt1 knockout mice. But its role
Eiji, Matsunaga, Tatsuya, Katahira, Harukazu, Nakamura   +2 more
openaire   +2 more sources