Results 171 to 180 of about 4,716 (190)

Lmx1b activation in axolotl limb regeneration

Developmental Dynamics, 2022
AbstractBackgroundAxolotls can regenerate their limbs. In their limb regeneration process, developmental genes are re‐expressed and reorganize the developmental axes, in which the position‐specific genes are properly re‐expressed. However, how such position specificity is reorganized in the regeneration processes has not been clarified. To address this
Sakiya Yamamoto, Rena Kashimoto, Saya Furukawa, Ayaka Ohashi, Akira Satoh   +4 more
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Renal phenotype in heterozygous Lmx1b knockout mice (Lmx1b +/−) after unilateral nephrectomy

Transgenic Research, 2007
The nail-patella syndrome (NPS) is a rare autosomal-dominant disorder which is caused by loss-of-function mutations in the transcription factor LMX1B. NPS is characterized by dysplastic nails, absent or hypoplastic patellae, minor skeletal abnormalities and nephropathy (in 20-40% of the cases), which is the most severe aspect of the disorder.
Sabine, Endele, Sabine, Klein, Sabine, Richter, Tina, Molter, Kerstin, Amann, Bernd, Klanke, Ralph, Witzgall, Randy L, Johnson, Karl F, Hilgers, Andreas, Winterpacht   +9 more
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Myelin bodies in LMX1B-associated nephropathy: potential for misdiagnosis

Pediatric Nephrology, 2020
Myelin figures, or zebra bodies, seen on electron microscopy were historically considered pathognomonic of Fabry disease, a rare lysosomal storage disorder caused by alpha-galactosidase A deficiency and associated with X-linked recessive mode of inheritance.
Li, Lei, Gia, Oh, Scott, Sutherland, Graham, Abra, John, Higgins, Richard, Sibley, Megan, Troxell, Neeraja, Kambham   +7 more
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Lmx1b‐dependent Activity of an Associated Enhancer Suggests Lmx1b Autoregulation

The FASEB Journal, 2017
Introduction Lmx1b is a homeobox transcription factor vital for proper limb dorsalization, as well as development of structures in the kidney, brain and eye. Within the developing limb bud, expression of Lmx1b is limited to the dorsal mesoderm.
Lauren A. Ivey, Endika Haro, Charmaine U. Pira, Kerby C. Oberg   +3 more
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Limb and kidney defects in Lmx1b mutant mice suggest an involvement of LMX1B in human nail patella syndrome

Nature Genetics, 1998
Dorsal-ventral limb patterning in vertebrates is thought to be controlled by the LIM-homeodomain protein Lmx1b which is expressed in a spatially and temporally restricted manner along the dorsal-ventral limb axis. Here we describe the phenotype resulting from targeted disruption of Lmx1b.
Chen H., Lun Y., Ovchinnikov D., Kokubo H., Oberg K.C., Pepicelli C.V., Gan L., Lee B., Johnson R.L.   +8 more
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Combined TSC1 and LMX1B mutations in a single patient

Clinical Dysmorphology, 2014
Tuberous sclerosis complex (TSC) and nail-patella syndrome (NPS) are autosomal dominant pleiotropic disorders with full penetrance that can both involve kidneys. TSC1 and NPS genes are located on chromosome 9q3. In a large family with the two disorders with two novel frameshift TSC1 and LMX1B mutations, we describe the phenotypes.
Ola, Khalifa, Nadia, Al-Sakati, Khalid, Al-Mane, Ameera, Balobaid, Zuhair N, Al-Hassnan   +4 more
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Lmx1b is essential for the development of serotonergic neurons

Nature Neuroscience, 2003
The specification and differentiation of serotonergic (5-HT) neurons require both extrinsic signaling molecules and intrinsic transcription factors to work in concert or in cascade. Here we identify the genetic cascades that control the specification and differentiation of 5-HT neurons in mice.
Yu-Qiang, Ding, Ulrika, Marklund, Wenlin, Yuan, Jun, Yin, Lauren, Wegman, Johan, Ericson, Evan, Deneris, Randy L, Johnson, Zhou-Feng, Chen   +8 more
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The signaling pathways of LMX1B and its role in glomerulosclerosis

Journal of Receptors and Signal Transduction, 2012
LMX1B, a developmental LIM-homeodomain transcription factor, is widely expressed in vertebrate embryos, and it takes part in the development of diverse structures such as limbs, kidneys, eyes, brains, etc. LMX1B contributes to transcriptional regulation of glomerular basement membrane (GBM) collagen expression by podocytes.
Tian-Biao, Zhou, Yuan-Han, Qin
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Deciphering Lmx1b regulation during development and evolution

2023
Trabajo presentado en la 16th International Conference on Limb Development, regeneration, and evolution, celebrada en Cambridge (Estados Unidos) del 08 al 11 de agosto de 2022.
Zdral, Sofía, Castilla-Ibeas, Alejandro, Naranjo Duran, Silvia, Mate, Irene, Juliá, Miguel, Galán, Laura, Tena, Juan J., Ros, María A.   +7 more
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Identification and characterization of LMX1B target genes

2016
Mutationen im LMX1B Gen sind mit einer autosomal-dominanten Erkrankung namens Nagel-Patella-Syndrom verbunden, die Gliedmaßen, Augen, Gehirn und Nieren beeinflusst. Hauptziele von LMX1B in den Nieren sind die Fussfortsätze und Schlitzmembran der Podozyten.
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