Results 151 to 160 of about 285,542 (254)

A Specific tRNA Half, 3'tiRNA‐GlyGCC, Regulates Hypoxic Pulmonary Artery Smooth Muscle Cell Proliferation via Myrf‐Mediated Endoplasmic Reticulum Stress

Cell Proliferation, EarlyView.
A schematic diagram illustrating how 3′tiRNA‐GlyGCC promotes the endoplasmic reticulum stress (ERS) and proliferation in hypoxic pulmonary artery smooth muscle cells (PASMCs) by inhibiting the expression of myelin regulatory factor (Myrf), ultimately leading to pulmonary hypertension (PH).
Lixin Zhang, Xiaoyu Guan, Xiangrui Zhu, Yingying Hao, Ya Xu, Hao Yuan, Danni Gao, Hongxia Du, Jiayu Li, Weiwei Cao, Cui Ma, Xiaoying Wang   +11 more
wiley   +1 more source

Protein-Protein Interaction Prediction with Identification of Putative Interaction Patterns

, 2007
蛋白質交互用作與其作用位置是了解生物體內運作的重要資訊，現在雖然已發展了許多實驗的方法來加以探測，但能得到的結果仍只是自然界的極小部分，為了增加探索速度，不少研究人員開發計算性的方法來預測，交互作用預測的準確度大致上都可以接受，但不是每個方法都能辨識出交互作用發生的位置，而一般用來預測作用介面的方法大都需要有三級結構的資訊來輔助，可是相較於已經解出的基因體序列，已知的結構資訊實在是太少了，所以這類的方法並不見得適用。 我們提出一個資料探勘演算法，其修改自挖掘關聯規則的Apriori演算法 ...
Tsai, Meng-Jia, 蔡孟家
core  

To Treat or Not to Treat: Navigating Early‐Stage CLL in the Era of Targeted Therapy

European Journal of Haematology, EarlyView.
ABSTRACT Chronic lymphocytic leukemia (CLL) is most frequently diagnosed at early, asymptomatic stages (Rai 0/Binet A), in which a watch‐and‐wait strategy remains the standard of care, based on historical trials demonstrating no overall survival benefit from early treatment.
Enrica Antonia Martino, Santino Caserta, Ernesto Vigna, Giovanna Cutrona, Antonella Bruzzese, Francesco Mendicino, Maria Eugenia Alvaro, Caterina Labanca, Eugenio Lucia, Virginia Olivito, Nicola Amodio, Franco Fais, Antonino Neri, Manlio Ferrarini, Valter Gattei, Fortunato Morabito, Massimo Gentile   +16 more
wiley   +1 more source

LncPTPred: predicting lncRNA-protein interaction based on crosslinking and immunoprecipitation (CLIP-Seq) data. [PDF]

Brief Bioinform
Das G, Das T, Ghosh Z.
europepmc   +1 more source

IRWNRLPI: Integrating Random Walk and Neighborhood Regularized Logistic Matrix Factorization for lncRNA-Protein Interaction Prediction. [PDF]

Front Genet, 2018
Zhao Q, Zhang Y, Hu H, Ren G, Zhang W, Liu H.   +5 more
europepmc   +1 more source

Targeting the microbiota‐miRNA‐protease axis: A new therapeutic avenue in melanoma

The FEBS Journal, EarlyView.
Modulation of extracellular matrix (ECM) turnover is central to melanoma progression and metastasis, driven largely by ECM proteases. This review highlights the epigenetic regulation of ECM proteases by microRNAs and their roles in melanoma growth, invasion, and immune modulation.
Elias N. Katsoulieris, Paraskevi Ioannou, Nikolaos A. Afratis   +2 more
wiley   +1 more source

Inter-view contrastive learning and miRNA fusion for lncRNA-protein interaction prediction in heterogeneous graphs. [PDF]

Brief Bioinform
Mao Y, Wu J, Weng J, Li M, Xiong Y, Gu W, Jiang R, Pang R, Lin X, Tang D.   +9 more
europepmc   +1 more source

LPI-NRLMF: lncRNA-protein interaction prediction by neighborhood regularized logistic matrix factorization. [PDF]

Oncotarget, 2017
Liu H, Ren G, Hu H, Zhang L, Ai H, Zhang W, Zhao Q.   +6 more
europepmc   +1 more source

Functional Aptamers in vitro Evolution for Protein-protein Interaction Blockage

As aptamer development progresses, their applications have expanded significantly beyond high affinity to include functional capabilities. Currently, identifying functional aptamers relies on traditional SELEX techniques, followed by functional ...
Qinguo, Liu, Jun, Li, Liqin, Zhang, Tongxuan, Wei   +3 more
core   +1 more source

Proteostasis of organelles in aging and disease

The FEBS Journal, EarlyView.
Cells rely on regulated proteostasis mechanisms to keep their internal compartments functioning properly. When these mechanisms fail, damaged proteins accumulate, disrupting organelles, such as the nucleus, mitochondria, endoplasmic reticulum, Golgi, and lysosomes, as well as membraneless organelles, such as stress granules, processing bodies, the ...
Yara Nabawi, Cansu Doğan, Dunja Petrović, Gülce Perçin, Seda Koyuncu, David Vilchez   +5 more
wiley   +1 more source