Results 91 to 100 of about 752,944 (283)

Circular RNA PTPN4 Contributes to Blood‐Brain Barrier Disruption during Early Epileptogenesis

Advanced Science, EarlyView.
Epileptic condition induces CircPTPN4 upregulation, which promotes ECE‐1 expression through competitive sequestration of miR‐145a‐5p. The elevated ECE‐1 catalyzes the ET‐1 production, leading to p38/MAPK pathway activation and subsequent downregulation of tight junction protein expression. This cascade results in increased BBB permeability and enhanced
Jiurong Yang, Yang Hu, Feiyu Wang, Xintao Peng, Honggang Qi, Yuanyuan Yao, Canyu Zhang, Lijie Zhou, Xuemei Liang, Kang Xu, Cong Zhang, Aifeng Zhang, Chen Chen, Yu Zeng, Chenchen Zhang, Guangming Gan, Xinjian Zhu   +16 more
wiley   +1 more source

A MIR17HG-derived Long Noncoding RNA Provides an Essential Chromatin Scaffold for Protein Interaction and Myeloma Growth.

Blood, 2022
Long noncoding RNAs (lncRNA) can drive tumorigenesis and are susceptible to therapeutic intervention. Here, we used a large-scale CRISPR interference viability screen to interrogate cell growth dependency to lncRNA genes in multiple myeloma (MM), and ...
E. Morelli, M. Fulciniti, M. Samur, C. Ribeiro, León Wert-Lamas, J. Henninger, Annamaria Gullà, Anil Aktas Samur, K. Todoerti, S. Talluri, W. D. Park, C. Federico, F. Scionti, N. Amodio, G. Bianchi, Megan E Johnstone, Natalie S Liu, D. Gramegna, Domenico Maisano, N. A. Russo, Charles Y. Lin, Y. Tai, A. Neri, D. Chauhan, T. Hideshima, M. Shammas, P. Tassone, S. Gryaznov, Rick Young, K. Anderson, C. Novina, M. Loda, N. Munshi   +32 more
semanticscholar   +1 more source

The long non-coding RNA GAS5 cooperates with the eukaryotic translation initiation factor 4E to regulate c-Myc translation. [PDF]

PLoS ONE, 2014
Long noncoding RNAs (lncRNAs) are important regulators of transcription; however, their involvement in protein translation is not well known. Here we explored whether the lncRNA GAS5 is associated with translation initiation machinery and regulates ...
Guangzhen Hu, Zhenkun Lou, Mamta Gupta
doaj   +1 more source

EZH2 RIP-seq Identifies Tissue-specific Long Non-coding RNAs. [PDF]

, 2018
BackgroundPolycomb Repressive Complex 2 (PRC2) catalyzes histone methylation at H3 Lys27, and plays crucial roles during development and diseases in numerous systems.
He, Yuan, Li, Lili, Tang, Lixu, Wang, Yan, Wang, Yibin, Wang, Zhihua, Xie, Yinping, Yu, Ling, Yu, Pengcheng, Zheng, Di   +9 more
core  

The Nefarious Nexus of Noncoding RNAs in Cancer [PDF]

, 2018
The past decade has witnessed enormous progress, which has seen the noncoding RNAs (ncRNAs) turn from the so called dark matter RNA to critical functional molecules, influencing most physiological processes in development and disease contexts.
Anastasiadou, Eleni, Faggioni, Alberto, J Slack, Frank, Trivedi, Pankaj   +3 more
core   +1 more source

The lncRNA MIAT regulates CPT-1a mediated cardiac hypertrophy through m6A RNA methylation reading protein Ythdf2

Cell Death Discovery, 2022
Pathological cardiac hypertrophy is a key contributor in heart failure (HF). Long non-coding RNAs (lncRNAs) and N 6 -methyladenosine (m 6 A) modification play a vital role in cardiac hypertrophy respectively.
Yiqing Yang, Muisha B. Mbikyo, Junzhe Zhang, Yuan Zhang, Naijin Zhang, Zhao Li   +5 more
semanticscholar   +1 more source

LncRNA–Protein Interactions: A Key to Deciphering LncRNA Mechanisms

Biomolecules
Long non-coding RNAs (lncRNAs) have emerged as pivotal regulators in a multitude of biological processes. However, their functional basis, particularly structure-based functional characteristics, remains elusive. lncRNAs exert their influence primarily through intricate interactions with various cellular components.
Zuoneng Wang, Muhammad Aftab, Zigang Dong, Yanan Jiang, Kangdong Liu   +4 more
openaire   +2 more sources

Annexin A13 Protects Against Acute Kidney Injury by Inactivating TGF‐β/Smad3 Signaling

Advanced Science, EarlyView.
ANXA13 is negatively regulated by Smad3 and exerts its protective role in AKI by inactivating TGF‐β/Smad3 signaling and Smad3‐p21 cell cycle arrest pathway through binding to TβRI, inhibiting the interaction between TβRI and TβRII, thereby suppressing TβRI phosporylation.
Jiaxiao Li, Chen Wu, Yuqi Zhu, Zicheng Liu, Wenjuan Yu, Andrew Lukwaro, Yu Zhong, Guoqiang Xie, Lili Zhou, Xiaoru Huang, Hui‐yao Lan, Junzhe Chen, Ying Tang   +12 more
wiley   +1 more source

Regulating Tumor Metabolic Reprogramming with Biomimetic Co‐Delivery of Simvastatin and Kynureninase for Immunotherapy

Advanced Science, EarlyView.
After the intravenous injection of biomimetic and pH/ROS‐responsive PTSK@CRM, the nanoparticles can be accumulated in tumors and release Sim and KYNase to inhibit the tumor growth, regulate the metabolism of cholesterol and Kyn, and reverse the immunosuppressive tumor microenvironment.
Jiaxin Yin, Shengcai Yang, Zengguang Liu, Songchen Zhao, Siyu Sun, Ziling Liu, Quanshun Li   +6 more
wiley   +1 more source

The Interaction of lncRNA-HEIH and lncRNA-HULC with HBXIP in Hepatitis B Patients

Gastroenterology Research and Practice, 2018
Hepatitis B virus (HBV) infection is a major risk factor for the development of hepatic cirrhosis (HC) and hepatocellular carcinoma (HCC), which are associated with very high morbidity and mortality rates worldwide.
Lingjuan Ruan, Lifei Huang, Lilai Zhao, Qiang Wang, Xiaocheng Pan, Anmin Zhang, Qiuping Bai, Zongjun Lv   +7 more
doaj   +1 more source