Results 81 to 90 of about 285,592 (275)
Advanced Science, EarlyView.ABSTRACT Class Switch Recombination (CSR) is essential for generating high‐affinity antibody isotypes from IgM during adaptive humoral responses. Despite well‐established roles for various transcription factors, whether CSR is subject to dedicated post‐transcriptional control represents a significant gap in knowledge.
Siyuan Sun +19 more
wiley +1 more source
Protein-protein interaction of Lupus
, 2020 Protein-protein interaction and biomarkers in ...
Danish Rehan (5608505) +2 more
core +1 more source
Semi-supervised prediction of protein interaction sentences exploiting semantically encoded metrics [PDF]
, 2009 Protein-protein interaction (PPI) identification is an integral component of many biomedical research and database curation tools. Automation of this task through classification is one of the key goals of text mining (TM).
Polajnar, T. +3 more
core +1 more source
Advanced Science, EarlyView.SMAD4 is identified as a guardian of 3D genome architecture in lung squamous cell carcinoma. Loss of SMAD4 unleashes EP300 at chromatin loop anchors, strengthening enhancer–promoter looping and H3K27ac at the SOX2 locus to drive aberrant SOX2 activation and tumor cell proliferation.
Qian Tang +33 more
wiley +1 more source
Advanced Science, EarlyView.Exosomal miR‐146a‐5p is identified as a pivotal regulator in steroid‐induced osteonecrosis. Its reduction activates NF‐κB signaling, compromises mitophagy, and disrupts mitochondrial bioenergetics, resulting in autophagic disequilibrium. Engineered exosomes delivering miR‐146a‐5p reinstate mitochondrial function, augment oxidative phosphorylation and ...
Zehui Lv +13 more
wiley +1 more source
The long non-coding RNA GAS5 cooperates with the eukaryotic translation initiation factor 4E to regulate c-Myc translation. [PDF]
PLoS ONE, 2014 Long noncoding RNAs (lncRNAs) are important regulators of transcription; however, their involvement in protein translation is not well known. Here we explored whether the lncRNA GAS5 is associated with translation initiation machinery and regulates ...
Guangzhen Hu, Zhenkun Lou, Mamta Gupta
doaj +1 more source
, 2020 Long non-coding RNAs (lncRNAs) play important roles in various biological processes, where lncRNA–protein interactions are usually involved. Therefore, identifying lncRNA–protein interactions is of great significance to understand the molecular functions
Pu-Feng Du (8158638) +5 more
core +1 more source
GILPI: Graphlet Interaction - based lncRNA-Protein Interaction Prediction
Identification of lncRNA-protein interactions is important for understanding the biological functions and molecular mechanisms of lncRNAs. In this study, we proposed a computational model for predicting lncRNA-protein interactions based on Graphlet interactions to find potential LPIs (GILPI). First, five LPI datasets were collected.
Hong-Yi Zhang, Yan Zhou
openaire +2 more sources
The Spatiotemporal Genetic Architecture of Seed Vigor in Upland Cotton
Advanced Science, EarlyView.Leveraging the semi‐automated SeedRanger platform, we profiled the germination kinetics of 356 cotton accessions at a 30‐min interval. This high‐throughput phenomic approach delineated a temporal genetic network comprising 541 stage‐specific loci. Crucially, functional validation identified FLA2 as a pivotal, auxin‐modulated regulator that orchestrates
Luyao Wang +32 more
wiley +1 more source
, 2020 Long non-coding RNAs (lncRNAs) play important roles in various biological processes, where lncRNA–protein interactions are usually involved. Therefore, identifying lncRNA–protein interactions is of great significance to understand the molecular functions
Pu-Feng Du (8158638) +5 more
core +1 more source