Results 91 to 100 of about 285,592 (275)

TDP‐43 Aggregation: The Healthy‐Toxic Balance of the Prion‐Like Domain

Advanced Science, EarlyView.
TDP‐43 function relies on a delicate balance between reversible phase‐separated states and irreversible aggregation. Under physiological conditions, TDP‐43 forms dynamic droplets and oligomers that support normal cellular functions. In pathological contexts, this balance shifts toward aberrant aggregation, leading to toxic species.
Luca Zangrando, Emanuele Buratti, Francesca Paron   +2 more
wiley   +1 more source

Table_3_Predicting lncRNA–Protein Interactions With miRNAs as Mediators in a Heterogeneous Network Model.xlsx

, 2020
Long non-coding RNAs (lncRNAs) play important roles in various biological processes, where lncRNA–protein interactions are usually involved. Therefore, identifying lncRNA–protein interactions is of great significance to understand the molecular functions
Pu-Feng Du (8158638), Yuan-Ke Zhou (8344617), Zi-Ang Shen (8344620), Han Yu (110573), Tao Luo (232520), Yang Gao (18005)   +5 more
core   +1 more source

A Computational Model of the LGI1 Protein Suggests a Common Binding Site for ADAM Proteins [PDF]

, 2011
Mutations of human leucine-rich glioma inactivated (LGI1) gene encoding the epitempin protein cause autosomal dominant temporal lateral epilepsy (ADTLE), a rare familial partial epileptic syndrome.
Leonardi, Emanuela, Tosatto, Silvio C. E., Giorgia Busolin, Simonetta Andreazza, Busolin, Giorgia, Tosatto, Silvio C E, Emanuela Leonardi, Carlo Nobile, Silvio C E Tosatto, TOSATTO, SILVIO, Busolin Giorgia, Silvio C. E. Tosatto, Tosatto Silvio C. E., Vanin, Stefano, Vanin Stefano, NOBILE C, Langowski, Jörg, Stefano Vanin, Andreazza Simonetta, Andreazza, Simonetta, Nobile, Carlo, ANDREAZZA A, Leonardi Emanuela, Nobile Carlo   +23 more
core   +1 more source

BoT-Net : a lightweight bag of tricks-based neural network for efficient LncRNA–miRNA interaction prediction

, 2022
Background and objective: Interactions of long non-coding ribonucleic acids (lncRNAs) with micro-ribonucleic acids (miRNAs) play an essential role in gene regulation, cellular metabolic, and pathological processes.
Dengel, Andreas,, Asim, Muhammad Nabeel, Dengel, Andreas, Ibrahim, Muhammad Ali, Trygg, Johan, Christoph Zehe, Zehe, Christoph,, Muhammad Nabeel Asim, Asim, Muhammad Nabeel,, Ibrahim, Muhammad Ali,, Johan Trygg, Ahmed, Sheraz,, Zehe, Christoph, Muhammad Ali Ibrahim, Trygg, Johan,, Andreas Dengel, Sheraz Ahmed, Ahmed, Sheraz   +17 more
core   +1 more source

Integrative Omics Analysis Reveals the Regulation of Hypoxia Tolerance in Large Yellow Croaker (Larimichthys crocea) via the Lipoic Acid Synthase (lias) Gene

Advanced Science, EarlyView.
Lipoic acid synthase (lias) can regulate α‐KG levels through lipoylation, thereby negatively regulating HIF‐1α protein levels via PHD under hypoixa. The Hap2 allele of lias exhibits lower expression levels than Hap1, leading to the accumulation of more HIF‐1α protein and thereby enhancing hypoxia tolerance. ABSTRACT Hypoxia stress seriously affects the
Jie Ding, Songpeng Jia, Ran Meng, Xuelei Wang, Xiongfei Wu, Weiliang Shen, Yibo Zhang, Junquan Zhu   +7 more
wiley   +1 more source

ProDGe: investigating protein-protein interactions at the domain level

, 2011
An important goal of systems biology is the identification and investigation of known and predicted protein-protein interactions to obtain more information about new cellular pathways and processes.
Andreas Dräger, Clemens Wrzodek, Adrian Schröder, Adrian Schröder, Florian Mittag, Andreas Zell, Finja Büchel, Andreas Dräger, Finja Büchel   +8 more
core   +1 more source

Predicting the interaction biomolecule types for lncRNA: an ensemble deep learning approach

, 2021
Long noncoding RNAs (lncRNAs) play significant roles in various physiological and pathological processes via their interactions with biomolecules like DNA, RNA and protein. The existing in silico methods used for predicting the functions of lncRNA mainly
Jia, Cangzhi, Zhang, Yu, Kwoh, Chee Keong   +2 more
core   +1 more source

A Solution for Exosome‐Based Analysis: Surface‐Enhanced Raman Spectroscopy and Artificial Intelligence

Advanced Intelligent Discovery, EarlyView.
Exosomes are emerging as powerful biomarkers for disease diagnosis and monitoring. This review highlights the integration of surface‐enhanced Raman spectroscopy with artificial intelligence to enhance molecular fingerprinting of exosomes. Machine learning and deep learning techniques improve spectral interpretation, enabling accurate classification of ...
Munevver Akdeniz, Zakarya Al‐Shaebi, Omer Aydin   +2 more
wiley   +1 more source

A system for the evolution of protein-protein interaction inducers

, 2021
Molecules that induce interactions between proteins, often referred to as “molecular glues”, are increasingly recognized as important therapeutic modalities and as entry points for rewiring cellular signaling networks.
Jeffrey, Dewey, Bryan, Dickinson, Saara-Anne, Azizi, Vivian, Lu   +3 more
core   +1 more source

Fusion of multi-source relationships and topology to infer lncRNA-protein interactions

Molecular Therapy - Nucleic Acids
Long non-coding RNAs (lncRNAs) are important factors involved in biological regulatory networks. Accurately predicting lncRNA-protein interactions (LPIs) is vital for clarifying lncRNA's functions and pathogenic mechanisms. Existing deep learning models have yet to yield satisfactory results in LPI prediction.
Xinyu Zhang, Mingzhe Liu, Zhen Li, Linlin Zhuo, Xiangzheng Fu, Quan Zou   +5 more
openaire   +3 more sources