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Clinica Chimica Acta, 2019
Ovarian cancer is one of the most common gynecologic malignancies and has a poor prognosis. Recently, long noncoding RNAs (lncRNAs) have been identified as key regulators of cancer development. Studies have shown that the dysregulation of lncRNAs is frequently observed in ovarian cancer and greatly contributes to malignant phenotypical changes. In this
Jin-yan Wang, Ai-qing Lu, Li-juan Chen
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Ovarian cancer is one of the most common gynecologic malignancies and has a poor prognosis. Recently, long noncoding RNAs (lncRNAs) have been identified as key regulators of cancer development. Studies have shown that the dysregulation of lncRNAs is frequently observed in ovarian cancer and greatly contributes to malignant phenotypical changes. In this
Jin-yan Wang, Ai-qing Lu, Li-juan Chen
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LncRNA MALAT1 Promotes Ulcerative Colitis by Upregulating lncRNA ANRIL
Digestive Diseases and Sciences, 2020LncRNA MALAT1 contributes to the inflammatory responses induced by lipopolysaccharides (LPS), which shares similar pathogenesis with ulcerative colitis (UC), indicating the potential involvement of MALAT1 in UC.Expression of MALAT1 and lncRNA ANRIL in both UC patients and healthy controls was analyzed by RT-qPCR. ROC curve analysis was used to evaluate
Mingyan Zhu, Jian Xie
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WIREs RNA, 2016
The diversity of long non‐coding RNAs (lncRNAs) in the human transcriptome is in stark contrast to the sparse exploration of their functions concomitant with their conservation and evolution. The pervasive transcription of the largely non‐coding human genome makes the evolutionary age and conservation patterns of lncRNAs to a topic of interest.
Peter F. Stadler +2 more
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The diversity of long non‐coding RNAs (lncRNAs) in the human transcriptome is in stark contrast to the sparse exploration of their functions concomitant with their conservation and evolution. The pervasive transcription of the largely non‐coding human genome makes the evolutionary age and conservation patterns of lncRNAs to a topic of interest.
Peter F. Stadler +2 more
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2015
All living organisms sense and respond to harmful changes in their intracellular and extracellular environment through complex signaling pathways that lead to changes in gene expression and cellular function in order to maintain homeostasis. Long non-coding RNAs (lncRNAs), a large and heterogeneous group of functional RNAs, play important roles in ...
Alberto Valencia-Hipólito +1 more
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All living organisms sense and respond to harmful changes in their intracellular and extracellular environment through complex signaling pathways that lead to changes in gene expression and cellular function in order to maintain homeostasis. Long non-coding RNAs (lncRNAs), a large and heterogeneous group of functional RNAs, play important roles in ...
Alberto Valencia-Hipólito +1 more
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Science Signaling, 2015
The interaction of a lncRNA with the complex of NF-κB and its inhibitor IκB prevents phosphorylation-mediated release and activation of NF-κB.
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The interaction of a lncRNA with the complex of NF-κB and its inhibitor IκB prevents phosphorylation-mediated release and activation of NF-κB.
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LncRNAs and Cardiovascular Disease
2022A novel class of RNA molecule emerged from human transcriptome sequencing studies termed long non-coding RNAs. These RNA molecules differ from other classes of non-coding RNAs such as microRNAs in their sizes, sequence motifs and structures. Studies have demonstrated that long non-coding RNAs play a prominent role in the development and progression of ...
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LncRNA 1600012P17Rik is a mouse placenta-specific lncRNA
Placenta, 2019Junxiao Wang +3 more
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