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Off-target effects as confounders of Cas13d-based lncRNA screens

Montero JJ, Trozzo R, Rad R.
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LncRNAs in Osteoarthritis

Clinica Chimica Acta, 2022
Osteoarthritis (OA) is a progressive joint disease that affects millions of older adults around the world. With increasing rates of incidence and prevalence worldwide, OA has become an enormous global socioeconomic burden on healthcare systems. Long non-coding ribonucleic acids (lncRNAs), essential functional molecules in many biological processes, are
Okuyan, Hamza Malik, Begen, Mehmet A.
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lncRNAs in mesenchymal differentiation

American Journal of Physiology-Cell Physiology, 2022
In recent years, technological advances have revealed a large potential number of long noncoding RNAs (lncRNAs). Findings recognize lncRNAs as orchestrating molecules in a wide range of processes, at the transcriptional and posttranscriptional levels, although fewer studies address function. For differentiation, which consists of rearrangements in the
Marcela Angelica, De la Fuente-Hernandez, Miguel Angel, Sarabia-Sanchez, Jorge, Melendez-Zajgla, Vilma, Maldonado-Lagunas   +3 more
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LncRNA MALAT1 Promotes Ulcerative Colitis by Upregulating lncRNA ANRIL

Digestive Diseases and Sciences, 2020
LncRNA MALAT1 contributes to the inflammatory responses induced by lipopolysaccharides (LPS), which shares similar pathogenesis with ulcerative colitis (UC), indicating the potential involvement of MALAT1 in UC.Expression of MALAT1 and lncRNA ANRIL in both UC patients and healthy controls was analyzed by RT-qPCR. ROC curve analysis was used to evaluate
Mingyan Zhu, Jian Xie
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LncRNAs and neoplasia

Clinica Chimica Acta, 2015
Long noncoding RNAs are emerging as new mediators of tumorigenesis by virtue of their various functions and their capacity to induce different mechanisms as a result of their wide spectrum of interactions. They play critical roles in a broad range of cellular processes including regulation of gene expression, imprinting, chromatin modification ...
Mustafa, Isin, Nejat, Dalay
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LncRNAs on guard

International Immunopharmacology, 2018
Long noncoding RNAs (lncRNAs) are emerging as crucial regulators of gene expression in immune system. It has been reported that lncRNAs participate in regulation of immune responses through both transcriptional and post-transcriptional mechanisms. In this review, we summarize the molecular functions of lncRNAs and discuss their binding to DNA, RNA and ...
Xue Li, Nan Li
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LncRNA NKILA Inhibits Retinoblastoma by Downregulating lncRNA XIST

Current Eye Research, 2019
Purpose: Although retinoblastoma is rare but can be deadly in some severe cases. To find novel therapeutic targets for retinoblastoma, we explored the potential role of lncRNA NKILA in retinoblastoma. Results: We found that, comparing to healthy controls, NKILA was downregulated, while lncRNA XIST was upregulated in plasma of retinoblastoma patients ...
Xueman, Lyu, Yunqing, Ma, Fei, Wu, Ling, Wang, Lina, Wang   +4 more
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F. nucleatum targets lncRNA ENO1-IT1 to promote glycolysis and oncogenesis in colorectal cancer

Gut, 2020
Objective Microbiota disorder promotes chronic inflammation and carcinogenesis. High glycolysis is associated with poor prognosis in patients with colorectal cancer (CRC).
Jie Hong, Fangfang Guo, Shi-Yuan Lu, Chao-qin Shen, Dangdang Ma, Xinyu Zhang, Yile Xie, Tingting Yan, TaChung Yu, T. Sun, Yun Qian, M. Zhong, Jinxian Chen, Yanshen Peng, Cheng Wang, Xiang Zhou, Jianju Liu, Qiang Liu, Xiong Ma, Yingxuan Chen, Haoyan Chen, J. Fang   +21 more
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