Results 361 to 370 of about 215,538 (386)

LncRNAs in Osteoarthritis

Clinica Chimica Acta, 2022
Osteoarthritis (OA) is a progressive joint disease that affects millions of older adults around the world. With increasing rates of incidence and prevalence worldwide, OA has become an enormous global socioeconomic burden on healthcare systems. Long non-coding ribonucleic acids (lncRNAs), essential functional molecules in many biological processes, are
Okuyan, Hamza Malik, Begen, Mehmet A.
openaire   +2 more sources

LncRNAs on guard

International Immunopharmacology, 2018
Long noncoding RNAs (lncRNAs) are emerging as crucial regulators of gene expression in immune system. It has been reported that lncRNAs participate in regulation of immune responses through both transcriptional and post-transcriptional mechanisms. In this review, we summarize the molecular functions of lncRNAs and discuss their binding to DNA, RNA and ...
Xue Li, Nan Li
openaire   +3 more sources

LncRNAs and neoplasia

Clinica Chimica Acta, 2015
Long noncoding RNAs are emerging as new mediators of tumorigenesis by virtue of their various functions and their capacity to induce different mechanisms as a result of their wide spectrum of interactions. They play critical roles in a broad range of cellular processes including regulation of gene expression, imprinting, chromatin modification ...
Mustafa Isin, Nejat Dalay
openaire   +3 more sources

LncRNA as Cancer Biomarkers

2021
Although the great majority of cancers share a defined group of hallmarks that is responsible for the uncontrolled growth of particular cell types, it is today clear that under the name of cancer we refer to hundreds of different diseases. Furthermore, each of these diseases has an intrinsic variability due to the genetic background in which it ...
Iaccarino, Ingram, Klapper, Wolfram
openaire   +2 more sources

The functions of LncRNA in the heart

Diabetes Research and Clinical Practice, 2020
Cardiovascular disease is a major cause of death and disability worldwide. Recently, increasing evidence has demonstrated that various lncRNAs play critical roles in the pathogenesis of cardiovascular diseases, including myocardial ischemia and reperfusion (I/R) injury. LncRNAs are transcripts longer than 200 nucleotides. They are considered a class of
Xianglan Sun, Yao Wang
openaire   +2 more sources

Computational recognition of lncRNA signature of tumor-infiltrating B lymphocytes with potential implications in prognosis and immunotherapy of bladder cancer

Briefings Bioinform., 2020
Long noncoding RNAs (lncRNAs) have been associated with cancer immunity regulation and the tumor microenvironment (TME). However, functions of lncRNAs of tumor-infiltrating B lymphocytes (TIL-Bs) and their clinical significance have not yet been fully ...
Meng Zhou   +6 more
semanticscholar   +1 more source

CircRNAs and LncRNAs in Osteoporosis

Differentiation, 2020
Osteoporosis is a systemic bone disease with bone fragility and increased fracture risk. The non-coding RNAs (ncRNAs) have appeared as important regulators of cellular signaling and pertinent human diseases. Studies have demonstrated that circular RNAs (circRNAs) and long non-coding RNAs (lncRNAs) are involved in the progression of osteoporosis through
Wei Liu   +11 more
openaire   +3 more sources

LncRNA NKILA Inhibits Retinoblastoma by Downregulating lncRNA XIST

Current Eye Research, 2019
Purpose: Although retinoblastoma is rare but can be deadly in some severe cases. To find novel therapeutic targets for retinoblastoma, we explored the potential role of lncRNA NKILA in retinoblastoma. Results: We found that, comparing to healthy controls, NKILA was downregulated, while lncRNA XIST was upregulated in plasma of retinoblastoma patients ...
Yunqing Ma   +4 more
openaire   +3 more sources

lncRNAs in mesenchymal differentiation

American Journal of Physiology-Cell Physiology, 2022
In recent years, technological advances have revealed a large potential number of long noncoding RNAs (lncRNAs). Findings recognize lncRNAs as orchestrating molecules in a wide range of processes, at the transcriptional and posttranscriptional levels, although fewer studies address function. For differentiation, which consists of rearrangements in the
Marcela Angelica, De la Fuente-Hernandez   +3 more
openaire   +2 more sources

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