Results 31 to 40 of about 402,825 (307)

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

Molecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié, Umberto Malapelle, Catherine Alix‐Panabières, Claus Lindbjerg Andersen, Sandra Chlebowski, Vivien Lake, Caroline Lacoux, Virginie Lespinet‐Fabre, Olivier Bordone, Simon Heeke, Christophe Bontoux, Ellen Heitzer, Klaus Pantel, Paul Hofman   +13 more
wiley   +1 more source

Study on Load-Bearing Characteristics and Engineering Applications for Cement–Soil Pipe Pile

Buildings
The cement–soil pipe pile is a novel blend of cement and soil, designed to enhance load-bearing capabilities while cutting down on the need for cement. Its tubular construction is key to its strength.
Chong Zhou, Xiangzhuo Zheng, Sifeng Zhang, Chao Li, Yaohui Yang, Jianyong Han   +5 more
doaj   +1 more source

Load carrying capacity of a heterogeneous surface bearing [PDF]

, 2015
It has been shown before that liquids can slip at a solid boundary, which prompted the idea that parallel-surfaces bearings can be achieved just by alternating slip and non-slip regions in the direction of fluid flow.
A Cameron, A Fatu, A Takeuchi, C W Wu, E Thomas, F Brochard, G Bayada, H Spikes, H Spikes, J H Choo, J P Rohstein, J-L Barrat, K Watanabe, L Leger, M D Pascovici, O I Vinogradova, R Pit, R Salant, V S J Craig, Y Zhu, Y Zhu   +20 more
core   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

Evolution Mechanism and Cyclic Degradation Model of Ultimate Bearing Capacity for Suction Caissons Under Inclined Combined Loading

Applied Sciences
In the marine environment, the suction caisson foundation (SCF) is often subjected to combined inclined and cyclic loading from wind and waves, which may significantly affect its ultimate bearing capacity. Under combined loading conditions, the evolution
Kang Huang, Bingzhen Yu, Bo Liu, Liji Huang, Huiyuan Deng, Wenbo Zhu, Guoliang Dai   +6 more
doaj   +1 more source

Shallow grooves in journal improve air bearing performance [PDF]

, 1968
Bearing designs, which shape the surface to create artificial fluid-film wedges in the absence of any applied radial load, generate radial restoring forces to keep journals from whirling.
Anderson, W. J., Cunningham, R. E., Fleming, D. P.   +2 more
core   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Spatial variability of precompression stress and volumetric water content of a red-yellow latosol (Oxisol)

Bioscience Journal, 2020
The intensive agricultural machinery traffic to which soils under coffee crops are exposed may cause significant changes in soil structure. The goals of this study were to: a) characterize the spatial variability of precompression stress (σp) and ...
Karina Marie Kamimura, Moacir de Souza Dias Júnior, Marcelo Silva de Oliveira, Gérson Rodrigues dos Santos, Paulo Tácito Gontijo Guimarães, Ayodele Ebenezer Ajayi   +5 more
doaj   +3 more sources

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source