Results 51 to 60 of about 181,070 (306)
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Applied SciencesIn the marine environment, the suction caisson foundation (SCF) is often subjected to combined inclined and cyclic loading from wind and waves, which may significantly affect its ultimate bearing capacity. Under combined loading conditions, the evolution
Kang Huang +6 more
doaj +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Advanced Bearing System for Ultra Precision Plastic Electronics Production Systems [PDF]
, 2014 The aims of this MSc research project are to investigate the application of aluminium for the main components of an ultra-precision spindle defined for use in R2R production systems and to produce a reel to reel rotary aluminium hydrostatic bearing ...
Zhao, Gang
core
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Effect of geosynthetic reinforcement on the bearing capacity of strip footing on sandy soil
, 2020 Due to the increasing presence of problematic soils, expansive clays and highly compressive sand engineers are using a verity of soil improvement techniques to treat such soils.
Al-Subari, L., Ekinci, A., Hanafi, M.
core +1 more source
Jixie chuandong, 2013 The load distribution analysis is the foundation of carrying load capacity analysis, the drawing of static carrying load capacity curve, designing and selecting of slewing bearing.
张黎燕 +3 more
doaj
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
Load-Bearing Capacity of Perforated Trapezoidal Sheeting
Steel & Composite Structures, 2010 Thin-walled perforated sheeting is used for sound absorption in buildings. The perforation may extend over the whole surface or only parts of the sheeting, e.g. webs. So far only reduction factors for the in-plane stiffness and the bending stiffness of fully perforated sheets with an equilateral triangular perforation pattern are included in EN 1993-1 ...
Misiek TH., Saal H.
openaire +4 more sources
Journal of the Civil Engineering ForumThe methods employed to calculate the axial bearing capacity of a helical pile depends on the shear failure model around the pile, which is also influenced by the spacing and diameter of the helical plates.
Ignatius Tommy Pratama +2 more
doaj +1 more source