Results 41 to 50 of about 181,070 (306)

Experimental Investigation on Web Crippling Property of High-Strength Cold-Formed (HSCF) Rectangular Steel Tube

open access: yesAdvances in Civil Engineering, 2020
To research the web crippling performance (i.e., the ultimate web crippling bearing capacity and ductility) of high-strength cold-formed (HSCF) rectangular steel tubes under concentrated load, thirty-six specimens with different bearing plate width ...
Xianglong Liu   +4 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

open access: yesMolecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat   +8 more
wiley   +1 more source

Improvement of bearing capacity of footings using reinforced granular trench

open access: yes, 2021
Recent evidence suggests that the stability performance of footings can be greatly enhanced using a granular trench. Therefore, this paper sets out to study the bearing capacity of strip footing on a two-layered soil system that is composed of overlying ...
Bhattacharya, Paramita   +2 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Bearing capacity of cold-formed unlipped channels with restrained flanges under EOF and IOF load cases

open access: yes, 2015
Bearing failure is a form of localized failure that occurs when thin-walled cold-formed steel sections are subjected to concentrated loads or support reactions.
Mahendran, Mahen   +2 more
core   +1 more source

Theoretical Analysis for Stability Evaluation of Rock Mass Engineering Structure under Combined Compression-Shear Loading: A Case Study of Inclined Pillar

open access: yesApplied Sciences, 2021
An inclined pillar is a typical support structure under compression and shear loads for underground mining. The shear load caused by the inclination of the ore-body affects the bearing capacity of the pillar.
Lijun Sun   +4 more
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

Ultimate Load-bearing Capacity of Self-anchored Suspension Bridges

open access: yes, 2011
This paper presents a method of reduced stiffness coupled with step increments to simulate the nonlinear problem that occurs when a material is in the elasto-plastic stage.
Kao, Chin-Sheng   +1 more
core   +1 more source

Analysis of a rapid load test on an instrumented bored pile in clay [PDF]

open access: yes, 2006
Rapid load testing methods for piled foundations are generally easier and quicker to mobilise than classic static tests, and are less complex to analyse than dynamic load tests.
Brown, M. J.; id_orcid   +2 more
core   +1 more source

Study on Load-Bearing Characteristics and Engineering Applications for Cement–Soil Pipe Pile

open access: yesBuildings
The cement–soil pipe pile is a novel blend of cement and soil, designed to enhance load-bearing capabilities while cutting down on the need for cement. Its tubular construction is key to its strength.
Chong Zhou   +5 more
doaj   +1 more source

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