Results 61 to 70 of about 181,070 (306)

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Load Bearing Capacity of Oil Film Bearing Research

, 2010
The oil film have many excellences such as bigger load bearing capacity, longer life, wider velocity range, lower friction etc. The traditional design method is experience test. Even the design parameters could meet the application requirements, but they
Jin Bao He, Jing Lin Tong, Jian Xi Yang, Xin Hua Yi, Hong Chao Fan   +4 more
core   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Load-bearing capacity and critical water content of the coffee plantation soil with management in full sun and shaded

, 2022
New management practices applied to coffee crops may influence the soil’s capacity to tolerate vertical stresses. This paper aimed to evaluate the influence of two coffee crop management systems on the soil load-bearing capacity and critical soil water ...
Kátia Daniela Ribeiro (13778761), Kasé Santos Lacerda (13778752), Kleber Mariano Ribeiro (13778758), Dorotéo de Abreu (13778764), Moacir de Souza Dias Junior (8368842), Rafaela Carvalho Vargas (13778755)   +5 more
core   +1 more source

Spatial variability of precompression stress and volumetric water content of a red-yellow latosol (Oxisol)

Bioscience Journal, 2020
The intensive agricultural machinery traffic to which soils under coffee crops are exposed may cause significant changes in soil structure. The goals of this study were to: a) characterize the spatial variability of precompression stress (σp) and ...
Karina Marie Kamimura, Moacir de Souza Dias Júnior, Marcelo Silva de Oliveira, Gérson Rodrigues dos Santos, Paulo Tácito Gontijo Guimarães, Ayodele Ebenezer Ajayi   +5 more
doaj   +3 more sources

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Change of Bearing Capacity Characteristics of Asphalt Pavement

, 2011
Time succession of data for monitored variable parameter of pavement state is the first step in development of degradation models and determination of degradation functions. Procedure used for characteristics of bearing capacity is described in the paper.
Jozef Komacka
core   +1 more source

Study of Rapid Evaluation Method for Structural Load-Bearing Capacity of Typical Rural Masonry Residential Buildings in Shandong Province, China

Advances in Civil Engineering
Typical rural masonry residential buildings mainly include brick–wood and brick–concrete structures, and they occupy a significant proportion among individual buildings in Shandong Province, and their structural reliability directly affects the safety of
Xu Zheng, Hongbin Wu, Zilin Lu, Sili Su, Runzhao Song   +4 more
doaj   +1 more source

Development of human monoclonal antibodies against TARM1 by yeast display

FEBS Open Bio, EarlyView.
Human monoclonal antibodies against TARM1 are generated by yeast display‐guided selection. These antibodies bind to soluble and cell‐surface forms of TARM1. Also, these antibodies exhibit agonistic activity in the NFAT‐GFP reporter assay, indicating that TARM1 signaling can be functionally modulated by antibodies and suggesting TARM1 as a potential ...
Rikio Yabe, Mayumi Saeki, Masaaki Hashiguchi, Sayaka Ono, Kazuhisa Aoki, Hidetaka Tanno   +5 more
wiley   +1 more source