Results 111 to 120 of about 1,160,595 (297)

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Determinación de diapasones de potencia necesarios para el control de frecuencia en el sistema eléctrico cubano; Determination of Necessary Ranges of Power for the Frecuency Control in Cuban Electric System

Revista Científica de Ingeniería Energética, 2011
Basado en un análisis estadístico de una base de datos en tiempo real se propone un procedimiento paradeterminar los diapasones de potencia activa necesarios para desarrollar un efectivo control de la frecuencia. A generalized approach
Antoino A Martínez García, Héctor S Llamo Labori, Maikop Pérez Martínez, Lázaro Guerra Hernández   +3 more
doaj  

Takagi-Sugeno fuzzy gain controller for Vehicle-to-Grid (V2G) load frequency control

Systems and Soft Computing
Load Frequency Control (LFC) has gained more importance with the introduction of deregulated Renewable Energy Sources (RES) connectivity with the grid.
Marayati Marsadek, Farrukh Nagi, Navinesshani Permal, Agileswari AP Ramasamy, Aidil Azwin   +4 more
doaj   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

Innovative Load Frequency Control: Integrating Adaptive Backstepping and Disturbance Observers

IEEE Access
Load frequency control (LFC) in large interconnected power systems is crucial for balancing electricity supply and demand while minimizing frequency deviations.
Javad Ansari, Mohamadreza Homayounzade, Ali Reza Abbasi   +2 more
doaj   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Optimization of Frequency Stability in Hydraulic Load Frequency Control Systems Using Controllers with Filters

Andalas Journal of Electrical and Electronic Engineering Technology
This study meticulously investigates the design and analysis of a Load Frequency Control (LFC) system tailored explicitly for hydraulic power systems by employing diverse configurations of PID controllers, namely Proportional (P), Proportional-Integral ...
Heru Dibyo Laksono, Dhea Rahmadani Putri , Mumuh Muharam , Rizki Wahyu Pratama   +3 more
doaj   +1 more source

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

Intelligent Load Frequency Control for Hybrid System With Renewable Integration

IEEE Access
This research investigates load frequency control (LFC) in hybrid power systems (HPS) with large-scale renewable energy sources (RESs). An intelligent standalone HPS is developed, integrating diverse power-generating units, variable loads, and electric ...
Pranendu Manna, Somnath Ganguly, Tanaya Datta Das, Joyti Mudi, K. Deepa, Pawan Kumar Pathak, Joon-Ho Choi   +6 more
doaj   +1 more source