Results 111 to 120 of about 12,777,871 (251)

Sequential decentralized design of load frequency controllers in multiarea power systems

open access: yes, 2003
A new systematic approach to design of sequential decentralized load frequency\ud controllers for multi-area power systems based on μ-synthesis is described.
Mitani, Yasunori   +2 more
core  

Amidst centralized and distributed frequency control in power systems

open access: yes, 2016
We propose a novel frequency control approach in between centralized and distributed architectures, that is a generalized continuous-time feedback control version of the dual decomposition optimization method.
GRAMMATICO, SERGIO   +7 more
core   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska   +13 more
wiley   +1 more source

Decentralised Load-frequency Control

open access: yes, 2015
We propose a numerical procedure to determine the load-frequency control of a power system composed of several interconnected areas. In order to decrease the associated implementation cost, the control law is constrained to have two different special ...
Geromel J.C., Peres P.L.D.
core  

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

open access: yesMolecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis   +3 more
wiley   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

open access: yesMolecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder   +10 more
wiley   +1 more source

THE MODELLING OF ELECTRIC POWER SYSTEMS ON THE STATE SPACE AND CONTROLLING OF OPTIMAL LQR LOAD FREQUENCY

open access: yesElectrica, 2009
The modelling of electric power systems on the state space and an optimal control system known as Linear Quadratic Regulator (LQR) for designing the load frequency control system are realized in this paper. In order to obtain high quality electric energy
ADNAN KAKİLLİ   +2 more
doaj   +2 more sources

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

open access: yesMolecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu   +13 more
wiley   +1 more source

Determinación de diapasones de potencia necesarios para el control de frecuencia en el sistema eléctrico cubano; Determination of Necessary Ranges of Power for the Frecuency Control in Cuban Electric System

open access: yesRevista Científica de Ingeniería Energética, 2011
Basado en un análisis estadístico de una base de datos en tiempo real se propone un procedimiento paradeterminar los diapasones de potencia activa necesarios para desarrollar un efectivo control de la frecuencia. A generalized approach
Antoino A Martínez García   +3 more
doaj  

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

open access: yesMolecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim   +3 more
wiley   +1 more source

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