Results 91 to 100 of about 1,670,871 (318)

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Determination of dynamic loads in the crane suspension when lifting a load from a rigid base

Гірничі, будівельні, дорожні та меліоративні машини
Loading and unloading works are an integral part of the construction process. Cranes of various types were mostly use to perform these works. To ensure trouble-free operation and increase the reliability of cranes, when calculating structures and ...
Volodymyr Volianiuk, Dmytro Mishchuk, Eugene Gorbatyuk   +2 more
doaj   +1 more source

Tissue-specific biomarkers in gingival crevicular fluid are correlated with external root resorption caused by constant mechanical load: an in vivo study

, 2021
Gui-Yue Huang, Sung‐Hwan Choi, Hwi-Dong Jung, Hyun Sil Kim, Chung–Ju Hwang, Kee‐Joon Lee   +5 more
openalex   +2 more sources

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Improving Efficiency of Rolling Mill Stand Electric Drives Through Load Alignment

Energies
The problem of reducing electric power consumption is critical to ferrous metallurgy as it is a very energy-intensive industry. Significant energy savings can be achieved by increasing the efficiency of high-power electric drives of rolling mills ...
Stanislav S. Voronin, Andrey A. Radionov, Alexander S. Karandaev, Roman A. Lisovsky, Boris M. Loginov, Mark A. Zinchenko, Vadim R. Khramshin, Ivan N. Erdakov   +7 more
doaj   +1 more source

Wind Loads for Stability Design of Large Multi-Span Duo-Pitch Greenhouses [PDF]

, 2017
A.J. Bronkhorst, C.P.W. Geurts, C.A. van Bentum, L.P.M. van der Knaap, Ina Pertermann   +4 more
openalex   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

An adaptive method for real‐time photovoltaic power forecasting utilizing mathematics and statistics: Case studies in Australia and Vietnam

IET Renewable Power Generation
The advancement of Photovoltaic technology has undergone rapid acceleration in recent years. Nonetheless, the most significant drawback of Photovoltaic is its intermittence, making it an obvious source of power fluctuation.
Tuyen Nguyen‐Duc, Huu Vu‐Xuan‐Son, Hieu Do‐Dinh, Nam Nguyen‐Vu‐Nhat, Goro Fujita, Son Tran‐Thanh   +5 more
doaj   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Identifying the ideal weekly training load for in-game performance in an elite Brazilian soccer team

Frontiers in Physiology
Introduction: The purpose of this study was to investigate the ideal training load to be applied during periods of fixture congestion to ensure an adequate dose-response effect for performance maintenance.Methods: Match performance data and corresponding
Luís Branquinho, Luís Branquinho, Luís Branquinho, Elias de França, José E. Teixeira, José E. Teixeira, José E. Teixeira, Adriano Titton, Luís Fernando Leite de Barros, Pedro Campos, Daniel A. Marinho, Daniel A. Marinho, Pedro Forte, Pedro Forte, Pedro Forte, Pedro Forte, Pedro Forte, Erico Chagas Caperuto, Ronaldo Vagner Thomatieli dos Santos, Ricardo Ferraz, Ricardo Ferraz   +20 more
doaj   +1 more source